H3K69 methylation is generally associated with transcriptional activation, with methylation catalyzed by DOT/DOT1L enzyme in the context of a nucleosome. Aberrant methylation of H3K79 has been implicated in leukemias. Histone H3 (69-89) peptides are used for assessing the specificity of anti-H3K79me antibodies.
Kouzarides, T. Curr Opin Genet Dev12, 198 (2002). Ng, HH. et al. Genes Dev16, 1518 (2002).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Arg - Leu - Val - Arg - Glu - Ile - Ala - Gln - Asp - Phe - Lys(Me3) - Thr - Asp - Leu - Arg - Phe - Gln - Ser - Ser - Ala - Val - NH2