Login
Existing Account

Please login first to complete purchase/ quotation request, view custom order reports, or create favorites list.

Customer ID:
Password:
Stay Logged In


Forgot your Customer ID or Password?
New Account

Don't have an account with us yet? Please set up an account to place order or obtain customer services.

Peptides  >  GPCR Peptide Ligands  >  Endothelin  >>  Endothelin 1, human, porcine

Product Name Endothelin 1, human, porcine
CSCSSLMDKECVYFCHLDIIW (Disulfide bridge: 1 - 15 and 3 - 11)
Size 0.25 mg
Catalog # 22859
US$ $181
Description

ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20C
References Ref: Yanagisawa, M. et al. Nature. 332, 411 (1988).
Molecular Weight 2492
Sequence
(One-Letter Code)
CSCSSLMDKECVYFCHLDIIW (Disulfide bridge: 1-15 and 3-11)
Sequence
(Three-Letter Code)
H - Cys - Ser - Cys - Ser - Ser - Leu - Met - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp - OH (Disulfide bridge: 1 - 15 and 3 - 11)
     
  < Back