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Peptides  >  Cyclic Peptides  >   Disulfide Cyclized Peptides  >>  RGD-targeted Proapoptotic Peptide

Product Name RGD - targeted Proapoptotic Peptide
ACDCRGDCFC - GG - klaklakklaklak - NH2 (S - S bonded C1 - C4 & C2 - C3)
Size 1 mg
Catalog # 62207
US$ $363
Purity % Peak Area By HPLC ≥ 95%
Description

This sequence is a targeted proapoptotic peptide. The C-terminal RGD-4C peptide (ACDCRGDCFC) binds preferentially to integrins at sites of tumor angiogenesis. Two glycines provide spacer, and D(KLAKLAK)2 is the proapoptotic peptide composed of D-amino acids.

Storage -20C
References Lahdenranta, J. et al. FASEB J. 10.1096/fj.07-8273com (2007); Ellerby, H. et al. Nat. Med. 5, 1032 (1999); Smolarczyk, R. et al. Acta Biochim. Pol. 53, 801 (2006); Curnis, F. et al. Cancer Res. 64, 565 (2004); Su, Z. et al. Bioconjug. Chem. 13, 561 (2002).
Molecular Weight 2707.4
Sequence
(One-Letter Code)
ACDCRGDCFC-GG-klaklakklaklak-NH2 (S-S bonded C1-C4 & C2-C3)
Sequence
(Three-Letter Code)
H - Ala - Cys - Asp - Cys - Arg - Gly - Asp - Cys - Phe - Cys - Gly - Gly - D - Lys - D - Leu - D - Ala - D - Lys - D - Leu - D - Ala - D - Lys - D - Lys - D - Leu - D - Ala - D - Lys - D - Leu - D - Ala - D - Lys - NH2 (S - S bonded C1 - C4 & C2 - C3)
     
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