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Peptides  >  Cyclic Peptides  >   Disulfide Cyclized Peptides  >>  Somatostatin 14, human, rat, mouse, pig, chicken, frog

Product Name Somatostatin 14, human, rat, mouse, pig, chicken, frog
AGCKNFFWKTFTSC (Disulfide bridge: 3 - 14)
Size 1 mg
Catalog # AS-24277
US$ $55
Purity % Peak Area By HPLC ≥ 95%
Description

Somatostatin [SST, GHIH (growth hormone-inhibiting hormone) or SRIF (somatotropin release-inhibiting factor)] is a cyclic peptide existing in two isoforms and is produced in the pancreas islet, GI tract and the central nervous system. Tetradecapeptide Somatostatin-14 (SRIF-14, the originally identified somatostatin) and the 28-amino acid Somatostatin-28 (SRIF-28) have similar biological activities but differ in their potency. Somatostatins inhibit the release of growth hormone in contrast to Growth Hormone Factor (GRF), which stimulates the release of growth hormone. Somatostatins also inhibit the release of prolactin and thyrotropin, peptide hormones from the pituitary gland and glucagon and insulin from the pancreas. It also controls the secretion of gut hormones and functions as a neurotransmitter.

Storage -20C
References Kim, D. et al. J Clin Endocrinol Metab 90, 6310 (2005)
Meyerhof, W. et al. Proc Natl Acad Sci USA 89, 10267 (1992)
Molecular Weight 1637.9
Sequence
(One-Letter Code)
AGCKNFFWKTFTSC (Disulfide bridge: 3-14)
Sequence
(Three-Letter Code)
H - Ala - Gly - Cys - Lys - Asn - Phe - Phe - Trp - Lys - Thr - Phe - Thr - Ser - Cys - OH (Disulfide bridge: 3 - 14)
Product Citations McGuire, N. et al. (2013). Gonadotropin releasing hormone (GnRH) and gonadotropin inhibitory hormone (GnIH) in the songbird hippocampus: regional and sex differences in adult zebra finches. Peptides 46, 64. doi: 10.1016/j.peptides.2013.05.007.
Keppel, T. et al. (2009). The use of acetone as a substitute for acetonitrile in analysis of peptides by liquid chromatography/electrospray ionization mass spectrometry. Rapid Comm Mass Spectrom 24, 6. doi: 10.1002/rcm.4352.
O'Donoghue, A. et al. (2008). Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii. J Biol Chem 283, 29186. doi: 10.1074/jbc.M802366200.
Zhao, X. et al. (2008). A homogeneous enzyme fragment complementation-based β-arrestin translocation assay for high-throughput screening of G-protein-coupled receptors. J Biomol Screen 13, 737.
     
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