This selective ET receptor subtype B agonist is a vasoconstrictor peptide. In experiments on renal vasoconstrictor actions, sarafotoxin 6c appears to be potent at the renal resistance vasculature and is powerfully modulated by NO. It plays a role in cytosolic Ca2+ concentration ([Ca2+]i) balance.The differences between central helix of the endothelin and sarafotoxin isopeptides might be important in binding of these ligands by the G protein-coupled endothelin receptors.
Ref: Mills, R. et al. J. Biol. Chem. 269, 23413 (1994); Watanabe, C. et al. Br. J. Pharmacol. 108, 30 (1993); Marshall, JL. and JJ. Edward, Br. J. Pharmacol. 128, 809 (1999).
Sequence (One-Letter Code)
CTCNDMTDEECLNFCHQDVIW (Disulfide bridge: 1-15 and 3-11)
Sequence (Three-Letter Code)
H - Cys - Thr - Cys - Asn - Asp - Met - Thr - Asp - Glu - Glu - Cys - Leu - Asn - Phe - Cys - His - Gln - Asp - Val - Ile - Trp - OH (Disulfide bridge: 1 - 15 and 3 - 11)