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Peptides  >  Apoptosis Peptides  >>  Caspase 1 Inhibitor

Product Name Caspase 1 Inhibitor
Size 1 mg
Catalog # AS-60856
US$ $55
Purity % Peak Area By HPLC ≥ 95%
Description

Caspase-1 inhibitors inhibit cell death in mammals and other vertebrates. This peptide is a specific peptide aldehyde inhibitor of ICE and is N-methylated. It is found to be neuroprotective in some animal models. N-Methylation of peptides is an important synthetic tool in peptide-based medicinal chemistry and is demonstrated as a useful modification that not only improves selectivity of peptides to targets but also improves key pharmacokinetic characters.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References Denes A. et al. Cell Death & Dis 3, e338 (2012).
Molecular Weight 506.6
Sequence
(Three-Letter Code)
Ac - (NMe)Tyr - Val - Ala - Asp - CHO
Product Citations Segovia, J. et al. (2012). TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection. PLoS ONE71: e29695. doi: 10.1371/journal.pone.0029695.
He, X. et al. (2010). Inflammation and fibrosis during chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome. J Immunol 18410:5743-54. doi:10.4049/jimmunol.0903937.
     
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