This peptide belongs to the functional domain of BAK, the member of the Bcl-2 family. Bak promotes apoptosis and binds anti-apoptotic family members including Bcl-2 and Bcl-xL. This domain in Bakt is necessary and sufficient for cytotoxic activity and binding to Bcl-xL. It is capable of modulating apoptosis in cells.
Chittenden, T. et al. EMBO J. 14, 5589 (1995).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Thr - Met - Gly - Gln - Val - Gly - Arg - Gln - Leu - Ala - Ile - Ile - Gly - Asp - Asp - Ile - Asn - Arg - Arg - Tyr - Asp - Ser - Glu - Phe - OH