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Peptides  >  Apoptosis Peptides  >>  SensoLyte AFC Caspase Profiling Kit *Fluorimetric*

Product Name SensoLyte AFC Caspase Profiling Kit *Fluorimetric*
Size 1 kit
Catalog # AS-71116
US$ $627
Description

Caspases play important roles in apoptosis and cell signaling. They are also identified as drug-screening targets. AFC-based substrates yield blue fluorescence upon protease cleavage. They are widely used to monitor caspase activity.

The SensoLyte Caspase Profiling Kit contains a series of AFC-based peptide substrates (Ex/Em=380 nm/500 nm) as fluorogenic indicators for assaying caspase protease activities. The kit contains a well-designed plate in which a series of AFC-based caspase substrates are coated with both positive and negative controls. It provides the best solution for profiling caspases or caspase inhibitors.

The kit contains:
A 96-well plate coated with a series of AFC-based caspase substrates along with various controls*
Cell lysis buffer
Assay buffer
AFC (fluorescence reference standard for calibration)
A detailed protocol A detailed protocol

*384-well plate format is available on a custom basis.

Kit Size: 2 plates

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20C
Product Citations Jaiswal, MK. et al. (2013). Regulation of apoptosis and innate immune stimuli in inflammation-induced preterm labor. J Immunol 191, 5702. doi: 10.4049/​jimmunol.1301604.
Shteingart, S. et al. (2012). Endoplasmic reticulum stress induces a caspase-dependent N-terminal cleavage of RBX1 protein in B cells. J Biol Chem 287, 31223.
Lopez, V. et al. (2010). Zip6-attenuation promotes epithelial-to-mesenchymal transition in ductal breast tumor (T47D) cells. Exp Cell Res 316, 366.
     
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