Angiotensins and Related Peptides

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Peptides > Angiotensins and Related Peptides

The renin-angiotensin system plays an important role in regulating blood volume, arterial pressure, cardiac and vascular function, and may contribute to the pathogenesis of atherosclerosis. It stimulates an increase in nitric oxide synthase mRNA, protein expression, and nitric oxide production in pulmonary vessels. This system is found in various vertebrates, from elasmobranchs to mammals. Angiotensins consist of at least three polypeptide hormones: angiotensin I (Ang I), angiotensin II (Ang II), and angiotensin III (Ang III). Ang I is derived from a protein secreted by the liver by the action of renin, an enzyme that acts on a circulating substrate, angiotensinogen, which then undergoes proteolytic cleavage to form the decapeptide Ang I. Ang I is converted to Ang II by the angiotensin converting enzyme (ACE) or kininase II, a dipeptidyl-carboxypeptidase. Ang II is a potent pressor agent in the regulation of blood pressure, the conservation of total blood volume and salt homeostasis. It controls the release of antidiuretic hormone (ADH) and aldosterone. Ang II is the precursor of Ang III, which in turn stimulates aldosterone release from the adrenal glands.

Ref: Lévy, B. Circulation 109, 8 (2004); Olson, S. et al. Am. J. Physiol. Lung. Cell Mol. Physiol. 287, L559 (2004); Johnston, CI. Drugs 39, 21 (1990); Kranzhofer, R. et al. Biochem. Biophys. Res. Commun. 257, 826 (1999); Takei, Y. et al. Gen. Comp. Endocrinol. 110, 140 (1998); Cobb, C. et al. Gen. Comp. Endocrinol. 127, 8 (2002); Spyroulias, G. et al. Eur. J. Biochem. 270, 2163 (2003).

Product	Size	Catalog #	US$
Angiotensin (1 - 5) DRVYI	1 mg	61179	$66

Angiotensin (1 - 7) DRVYIHP	1 mg	61039	$66

Angiotensin (1 - 9) DRVYIHPFH	1 mg	61041	$83

Angiotensin I Converting Enzyme 2, (ACE - 2) Substrate Mca - APK(Dnp)	1 mg	60757	$132

Angiotensin I Converting Enzyme 2, ACE - 2/Caspase - 1 Substrate Mca - YVADAPK(Dnp)	1 mg	60758	$237

Angiotensin I, human DRVYIHPFHL	5 mg	20627	$25

Angiotensin I, human DRVYIHPFHL	25 mg	20628	$121

Angiotensin I/II (3 - 8) VYIHPF	5 mg	60701	$44

Angiotensin II Substrate DRV - pY - IHPF	1 mg	24520	$237

Angiotensin II Substrate DRV - pY - IHPF	5 mg	24521	$946

Angiotensin II, human DRVYIHPF	5 mg	20633	$33

Angiotensin II, human DRVYIHPF	25 mg	20634	$121

Angiotensin II, human, FAM - labeled FAM - DRVYIHPF	0.5 mg	60275-05	$105

Angiotensin II, human, FAM - labeled FAM - DRVYIHPF	1 mg	60275-1	$171

Angiotensin II, human, TAMRA - labeled TAMRA - DRVYIHPF	1 mg	61181	$181

Angiotensin III RVYIHPF	5 mg	60704	$44

Apstatin, Aminopeptidase P Inhibitor N - [(2S,3R) - 3 - amino - 2 - hydroxy - 4 - phenylbutanoyl ] - PPA - NH2	1 mg	61832-1	$71

Apstatin, Aminopeptidase P Inhibitor N - [(2S,3R) - 3 - amino - 2 - hydroxy - 4 - phenylbutanoyl ] - PPA - NH2	5 mg	61832-5	$242

Apstatin, Aminopeptidase P Inhibitor N - [(2S,3R) - 3 - amino - 2 - hydroxy - 4 - phenylbutanoyl ] - PPA - NH2	25 mg	61832-25	$1111

Biotin - LC - Angiotensin II Biotin - LC - DRVYIHPF	1 mg	60276-1	$66

Biotin - LC - Angiotensin II Biotin - LC - DRVYIHPF	5 mg	60276-5	$264

ClearPoint^™ Angiotensin I, human, 13C and 15N labeled DR - V* - Y - I* - HPFHL [Val* = Val(U - 13C5,15N); Ile* = Ile(U - 13C6,15N)]	0.1 mg	65140	$77

ClearPoint^™ Angiotensin II, human, 13C and 15N - labeled DRVY - I* - HPF [I*= I(U¹³C6,¹⁵N)]	0.1 mg	64805	$143

ClearPoint™ Angiotensin I, human, 13C and 15N - labeled DRVY - I* - HPFHL [I*= I(U¹³C6,¹⁵N)]	0.1 mg	61182	$143

DX 600, ACE2 Inhibitor Ac - GDYSHCSPLRYYPWWKCTYPDPEGGG - NH2	0.1 mg	62337	$121

HRP Prorenin, Decoy Handle Region (31 - 40), rat RILLKKMPSV	1 mg	62118	$61

Peptide Substrate for Renin 520 Assay kit	0.1 mg	61872-01	$220

Peptide Substrate for Renin 520 Assay kit	1 mg	61872	$1320

Rat Renin FRET Substrate (5 - FAM/QXL™520)	0.1 mg	62334-01	$220

Rat Renin FRET Substrate (5 - FAM/QXL™520)	1 mg	62334	$1320

Rat Renin Inhibitor Peptide, WFML Peptide Ac - HPFV - (Sta) - LF - NH2	1 mg	60463-1	$181

Renin 390 FRET Substrate I R - E(EDANS) - IHPFHLVIHT - K(DABCYL) - R	1 mg	62022	$215

Renin Inhibitor III RRPFH - Sta - IHK	5 mg	72066	$775

Renin Substrate, human	1 mg	20631	$61

Renin Substrate, human DRVYIHPFHLVIHN	5 mg	20632	$193

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