Cell Permeable Peptides (CPP) / Drug Delivery Peptides

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Peptides > Cell Permeable Peptides (CPP) / Drug Delivery Peptides

Efficient transfer of proteins or nucleic acids across cellular membranes is one of the major problems in cell biology. To deliver the functional domain of a selected protein from the outside to the inside of intact cells, a carrier is needed. Cell Permeable Peptides, also known as Protein Transduction Domains (PTDs), are carriers with small peptide domains that can freely cross cell membranes. Several PTDs have been identified that allow a fused protein to efficiently cross cell membranes in a process known as protein transduction. Studies have demonstrated that a TAT peptide derived from the HIV TAT protein has the ability to transduce peptides or proteins into various cells. PTDs have been utilized in anticancer strategy, for example, a cell permeable Bcl-2 binding peptide, cpm1285, shows activity in slowing human myeloid leukemia growth in mice. Cell-permeable phosphopeptides, such as FGFR730pY, which mimics receptor binding sites for specific SH2 domain-containing proteins are potential tools for cancer research and cell signaling mechanism studies.

Time-lapse video of FITC-LC-Antennapedia peptide (cat# 24175, 24176)
entry into a neuronal cluster of cells. Video courtesy of Dr. E. Gruenstein,
Univ. of Cincinnati Medical School, Cincinnati, OH.

Figure 1. Uptake of CPP by HeLa cells. HeLa cells were incubated with OptiMEM
medium containing 10 uM FITC-LC-Antennapedia, cat# 24175, 24176 (panel A) and
10 uM of TAMRA-labelled TAT (47-57), cat# 61211(B) for 1 h, washed and analyzed
by fluorescence microscopy.

Ref: Embury, J. et al. Diabetes 50, 1706 (2001), Wang, H. et al. J. Clin. Invest. 109, 1463 (2002); Lin, Y-Z. J. Biol. Chem. 270, 14255 (1995); Holzberg, D. et al. J. Biol. Chem. 278, 40213 (2003); Williams, E. et al. J. Biol. Chem. 272, 22349 (1997); Nakatani, KH. et al. Nat. Med. 10, 1128 (2004); Mortlock, A. et al. Nucleic Acids Res. 31, e152 (2003); Kaneto, H. et al. Nat. Med. 10, 1128 (2004); Wang, JL. et al. Cancer Res. 60, 1498 (2000); Oess S. and E. Hildt, Gene. Ther. 7, 750 (2000); Dunican, D. et al. Cell Growth Diff. 12, 255 (2001).

Product	Size	Catalog #	US$
(Arg)9 RRRRRRRRR	1 mg	61204	$61

(Arg)9 biotin labeled Biotin - LC - RRRRRRRRR - NH2	1 mg	64078	$105

(Arg)9, FAM - labeled FAM - RRRRRRRRR	1 mg	61207	$242

(Arg)9, TAMRA - labeled TAMRA - RRRRRRRRR	1 mg	61208	$264

[Cys58]105Y, Cell Penetrating Peptide, α1 - antitrypsin (358 - 374) CSIPPEVKFNKPFVYLI	1 mg	62005	$105

Aminopeptidase N Ligand (CD13), NGR peptide CNGRCG (Disulfide bridge: 1 - 5)	1 mg	60171-1	$121

Aminopeptidase N Ligand (CD13), NGR peptide CNGRCG (Disulfide bridge: 1 - 5)	5 mg	60171-5	$484

Antennapedia Leader Peptide (CT) KKWKMRRNQFWVKVQRG	1 mg	61376	$105

Antennapedia Peptide, acid RQIKIWFQNRRMKWKK	1 mg	61032	$99

Antennapedia Peptide, amide RQIKIWFQNRRMKWKK - NH2	1 mg	61033	$99

Antennapedia Peptide, FAM - labeled 5 - FAM - RQIKIWFQNRRMKWKK - NH2	1 mg	64212	$242

Anti - BetaGamma (MPS - Phosducin - like protein C terminus) AAVALLPAVLLALLAVTDQLGEDFFAVDLEAFLQEFGLLPEKE	0.5 mg	24177	$242

Anti - BetaGamma (MPS - Phosducin - like protein C terminus) AAVALLPAVLLALLAVTDQLGEDFFAVDLEAFLQEFGLLPEKE	1 mg	24178	$435

Bcl - 2 Binding Peptide, cell permeable Decanoyl - KNLWAAQRYGRELRRMSDEFEGSFKGL	1 mg	64127	$215

Biotin - TAT (47 - 57) Biotin - YGRKKRRQRRR	1 mg	61209	$115

Buforin TRSSRAGLQFPVGRVHRLLRK	1 mg	61255	$176

Chimeric Rabies Virus Glycoprotein Fragment (RVG - 9R) YTIWMPENPRPGTPCDIFTNSRGKRASNGGGGRRRRRRRRR	1 mg	62565	$484

Cys(Npys) Antennapedia Peptide, amide C(Npys) - RQIKIWFQNRRMKWKK - NH2	1 mg	61034	$143

Cys(Npys) - (Arg)9 C(Npys)RRRRRRRRR - NH2	1 mg	61205	$242

Cys(Npys) - (D - Arg)9 C(Npys)rrrrrrrrr - NH2	1 mg	61206	$291

Cys(Npys) - TAT (47 - 57) C(Npys)YGRKKRRQRRR - NH2	1 mg	61214	$242

Cys(Npys) - TAT (47 - 57), FAM - labeled C(Npys)YGRKKRRQRRR - K(FAM) - NH2	1 mg	61213	$291

Cys - TAT (47 - 57) CYGRKKRRQRRR - NH2	1 mg	61212	$99

FITC - LC - Antennapedia Peptide FITC - LC - RQIKIWFQNRRMKWKK - NH2	0.5 mg	24175	$154

FITC - LC - Antennapedia Peptide FITC - LC - RQIKIWFQNRRMKWKK - NH2	1 mg	24176	$242

FITC - LC - MTS FITC - LC - AAVLLPVLLAAP - NH2	0.5 mg	24188	$242

FITC - LC - MTS FITC - LC - AAVLLPVLLAAP - NH2	1 mg	29851	$435

FITC - LC - TAT (47 - 57) FITC - LC - YGRKKRRQRRR - NH2	0.5 mg	27042	$154

FITC - LC - TAT (47 - 57) FITC - LC - YGRKKRRQRRR - NH2	1 mg	27043	$242

Hel 13 - 5 KLLKLLLKLWLKLLKLLL	1 mg	63894	$121

HIV - 1 Tat (48 - 60) GRKKRRQRRRPPQ	1 mg	63847	$83

Mastoparan INLKALAALAKKIL - NH2	1 mg	24270	$49

Mastoparan INLKALAALAKKIL - NH2	5 mg	24269	$193

Mastoparan 7 INLKALAALAKALL - NH2	1 mg	62646	$93

Mastoparan X INWKGIAAMAKKLL - NH2	1 mg	62647	$93

MEK1 Derived Peptide Inhibitor 1 MPKKKPTPIQLNP	5 mg	60185-5	$313

Membrane - Permeable Sequence, MPS AAVALLPAVLLALLAK	1 mg	61218	$99

MPGΔNLS, HIV related; GALFLGFLGAAGSTMGAWSQPKSKRKV	1 mg	60633	$363

MPS - Gαi3 AAVALLPAVLLALLAKNNLKECGLY	1 mg	61217	$198

NGR Peptide 1 CNGRCGGklaklakklaklak - NH2 (Disulfide bridge: 1 - 5)	1 mg	60189-1	$237

NGR Peptide 2 CNGRCGGLVTT (Disulfide bridge: 1 - 5)	1 mg	60190-1	$115

NGR Peptide 3 CNGRC - NH2 (Disulfide bridge: 1 - 5)	1 mg	60191-1	$121

NGR Peptide 3 CNGRC - NH2 (Disulfide bridge: 1 - 5)	5 mg	60191-5	$484

Nuclear Localiation Signal Peptide PKKKRKV	1 mg	61257	$71

P22 N (14 - 30) NAKTRRHERRRKLAIER	1 mg	64204	$105

Penetratin RQIKIWFQNRRMKWKKGG	1 mg	64885	$99

Pep - 1 - Cysteamine Ac - KETWWETWWTEWSQPKKKRKV - cysteamine	1 mg	63849	$193

Pep - 1: Chariot (Non - Covalent Delivery of Peptides and Proteins) KETWWETWWTEWSQPKKKRKV	1 mg	61253	$176

Rabies Virus Glycoprotein (RVG) YTIWMPENPRPGTPCDIFTNSRGKRASNG	1 mg	62566	$225

SV - 40 Large T - antigen Nuclear Localization Signal (NLS) CGGGPKKKRKVED	1 mg	63831	$77

SV40 T - Ag - derived Nuclear Localization Signal (NLS) Peptide PKKKRKVEDPYC	1 mg	63788	$83

SynB1 RGGRLSYSRRRFSTSTGRA	1 mg	61254	$115

TAT (47 - 57) YGRKKRRQRRR	1 mg	60023-1	$93

TAT (47 - 57) YGRKKRRQRRR	5 mg	60023-5	$363

TAT (47 - 57) GGG - Cys(Npys) YGRKKRRQRRRGGG - C(Npys) - NH2	1 mg	61215	$242

TAT (47 - 57), FAM - labeled FAM - YGRKKRRQRRR	1 mg	61210	$203

TAT (47 - 57), TAMRA - labeled TAMRA - YGRKKRRQRRR	1 mg	61211	$231

Tat (48 - 57) GRKKRRQRRR	1 mg	62064	$61

Tat - C (48 - 57) CGRKKRRQRRR	1 mg	62063	$66

TAT - GluR2_3A Fusion Peptide YGRKKRRQRRRAKEGANVAG	1 mg	64984	$110

Tat - GluR23Y YGRKKRRQRRRYKEGYNVYG	1 mg	64429	$110

Tat - GluR23Y, scrambled YGRKKRRQRRRVYKYGGYNE	1 mg	64428	$110

TAT - HA2 Fusion Peptide RRRQRRKKRGGDIMGEWGNEIFGAIAGFLG	1 mg	64876	$215

Tat - NR2Bct YGRKKRRQRRRKLSSIESDV	1 mg	62042	$237

TAT - NSF222 Fusion Peptide YGRKKRRQRRR - GGG - LDKEFNSIFRRAFASRVFPPE	1 mg	62240	$313

TAT - NSF222scr Fusion Polypeptide, scrambled YGRKKRRQRRR - GGG - ENSFRFLADIFPAKAFPVRFE	1 mg	62210	$308

TAT - NSF700 Fusion Peptide YGRKKRRQRRR - GGG - LLDYVPIGPRFSNLVLQALLVL	1 mg	62238	$325

TAT - NSF700scr YGRKKRRQRRRGGGIPPVYFSRLDLNLVVLLLAQL	1 mg	62209	$308

TAT - NSF81scr Fusion Polypeptide , scrambled YGRKKRRQRRR - GGG - QDGCKYFATDETIMKLSIAI	1 mg	62215	$269

TfR Targeting Peptide THRPPMWSPVWP	1 mg	64689	$66

Transdermal Peptide ACSSSPSKHCG	1 mg	62066	$61

Transportan GWTLNSAGYLLGKINLKALAALAKKIL	1 mg	61256	$237

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