Peptides  >  Cholecystokinin-Pancreozymin Peptides
Cholecystokinin (CCK), also called pancreozymin, is a peptide hormone discovered in the small intestine. Together with secretin and gastrin, it constitutes the classical gut hormone triad. As a gastrointestinal hormone, CCK is secreted into the blood following ingestion of a meal and plays a critical role in the ingestion, absorption, intestinal motility, satiety signaling, inhibition of gastric acid secretion and digestion of food. Ingested protein and fat are potent stimulants of CCK secretion. CCK induces the gall bladder to contract and eject bile into the intestine. It also regulates pancreatic enzyme secretion and growth. It is known to induce growth of the exocrine pancreas and to stimulate insulin secretion. A transmitter in central and intestinal neurons, CCK is the most abundant neuropeptide in the human brain. This peptide also induces panic attacks. The panicogenic effects of cholecystokinin-tetrapeptide are antagonized by a central cholecystokinin receptor antagonist. ProCCK is expressed in certain neuroendocrine tumors and sarcomas, and the secretion of CCK is impaired in celiac disease and bulimia nervosa. Caerulein is a decapeptide analog of the potent pancreatic secretagogue, cholecystokinin. It stimulates gastric, biliary and pancreatic secretion. In mice, caerulein injections cause acute pancreatitis.

Ref: Della-Fera, MA. and CA. Baile, Science 206, 471 (1979); Zwanzger, P. et al. Neuropsychopharmacol. 28, 979 (2003); Abelson JL. and I. Liberzon Neuropsychopharmacol. 21, 485 (1999); Kobelt P. et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R751 (2005); Yamamoto, M. et al. Am. J. Physiol. Gastrointest. Liver Physiol. (2004); Aouizerate, B. et al. Encephale. 30, 301 (2004); Kuntz, E. et al. JOP 5, 464 (2004); Rehfeld, JF. Best Pract. Res. Clin. Endocrinol. Metab.18, 569 (2004); Wang, Y. et al. Am. J. Physiol. Gastrointest. Liver Physiol. 282, G16 (2002); Beinfeld, MC. and M. Palkovits, Brain Res. 238, 260 (1982); Bradwejn, J. and D. Koszycki, Ann. N.Y. Acad. Sci. 713, 273 (1994); Bradwejn, J. and D. Koszycki, Am. J. Psychiatry 151, 261 (1994); Bradwejn, J. et al. Annable L. Arch. Gen. Psychiat. 5, 486 (1994); Bhatia, M. et al. Proc. Natl. Acad. Sci. USA 95, 4760 (1998).
 Product Size Catalog # US$  
[Thr28, Nle31] - Cholecystokinin (25 - 33), sulfated
RD - Y(SO3H) - TGW - Nle - DF - NH2
1 mg 22944 $242
Caerulein
Pyr - QD - Y(SO3H) - TGWMDF - NH2
0.5 mg 24251 $121
Caerulein
Pyr - QD - Y(SO3H) - TGWMDF - NH2
1 mg 24252 $198
Cholecystokinin (26 - 33), CCK Octapeptide, sulfated
D - Y(SO3H) - MGWMDF - NH2
1 mg 20741 $198
Cholecystokinin (26 - 33), CCK8
DYMGWMDF - NH2
1 mg 20739 $99
Cholecystokinin (26 - 33), CCK8
DYMGWMDF - NH2
5 mg 20740 $385
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