Matrix Metalloproteinases (MMPs)

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Peptides > Matrix Metalloproteinases (MMPs)

Matrix metalloproteinases (MMPs) are a family of highly homologous protein-degrading zinc dependent enzymes endopeptidases.This family currently includes more than 25 members that can be divided into collagenases (MMP-1, -8, and -13), gelatinases (MMP-2 and 9), stromelysins (MMP-3 and 10), matrilysins (MMP-7 and 26), and the membrane-type MMPs (MMP-14 to 17 and 24). MMPs are important in many normal biological processes including embryonic development, angiogenesis, and wound healing, as well as in pathological processes such as inflammation, cancer, and tissue destruction. MMPs collectively cleave most, if not all, of the constituents of the extracellular matrix (ECM) and are involved in the breakdown and remodeling of many tissues and organs.

Ref: Birkedal-Hansen, H. et al. Crit. Rev. Oral Biol. Med. 4, 197 (1993 ); Lenhart, J. et al. Endocrinol. 142, 3941 (2001); Gabison, EE. et al. Am. J. Pathol. 166, 209 (2005); Isaksen, B. and MK. Fagerhol, J. Clin. Pathol. Mol. Pathol. 54, 289 (2001).

Product	Size	Catalog #	US$
360 MMP FRET Substrate I Dnp - PLGLWAr - NH2	1 mg	27074	$99

360 MMP FRET Substrate I Dnp - PLGLWAr - NH2	5 mg	27075	$341

360 MMP FRET Substrate II Dnp - PLALWAR	1 mg	27082	$71

360 MMP FRET Substrate II Dnp - PLALWAR	5 mg	27083	$291

360 MMP FRET Substrate III Dnp - PLGMWSR	1 mg	27094	$71

360 MMP FRET Substrate IV Dnp - PYAYWMR	1 mg	27098	$71

360 MMP FRET Substrate IV Dnp - PYAYWMR	5 mg	27099	$291

360 MMP FRET Substrate V Dnp - RPLALWRS	1 mg	27102	$71

360 MMP FRET Substrate VI Dnp - PLAYWAR	1 mg	27106	$71

360 MMP FRET Substrate VI Dnp - PLAYWAR	5 mg	27107	$291

390 MMP FRET Substrate I Mca - PLGL - Dpa - AR - NH2 Mca - PLGL - Dap(Dnp) - AR - NH2	1 mg	27076	$99

390 MMP FRET Substrate I Mca - PLGL - Dpa - AR - NH2 Mca - PLGL - Dap(Dnp) - AR - NH2	5 mg	27077	$396

390 MMP FRET Substrate II Mca - PLGL - Dpa - AR Mca - PLGL - Dap(Dnp) - AR	5 mg	27079	$385

390 MMP FRET Substrate III Mca - PLA - Nva - Dpa - AR - NH2 Mca - PLA - Nva - Dap(Dnp) - AR - NH2	1 mg	27090	$99

390 MMP FRET Substrate IV Mca - P - Cha - G - Nva - HA - Dpa - NH2 Mca - P - Cha - G - Nva - HA - Dap(Dnp) - NH2	1 mg	27108	$99

390 MMP FRET Substrate IV Mca - P - Cha - G - Nva - HA - Dpa - NH2 Mca - P - Cha - G - Nva - HA - Dap(Dnp) - NH2	5 mg	27109	$385

390 MMP FRET Substrate V Mca - PLGLEEA - Dpa - NH2 Mca - PLGLEEA - Dap(Dnp) - NH2	1 mg	62027	$83

490 MMP FRET Substrate III DABCYL - RPLALWRS - EDANS	1 mg	27104	$220

490 MMP FRET Substrate IV DabcylPlus - KPLA - Nva - D(EDANS) - AR - NH2	0.1 mg	60637	$93

490 MMP FRET Substrate V NBD - RPKPLA - Nva - WK(DMC) - NH2	1 mg	60563-1	$363

5 - FAM MMP FRET Peptide Fluorescence Standard I 5 - FAM - PL	0.1 mg	60584-01	$115

520 MMP FRET Substrate I QXL™ 520 - PLGLWArK(5 - FAM) - NH2	0.1 mg	60568-01	$159

520 MMP FRET Substrate II QXL™ 520 - PLALWARK(5 - FAM) - NH2	0.1 mg	60569-01	$159

520 MMP FRET Substrate III QXL™ 520 - PLGC(Me)HAr - K(5 - FAM) - NH2	0.1 mg	60570-01	$159

520 MMP FRET Substrate IV 5 - FAM - PLA - Nva - Dap(QXL™ 520) - AR - NH2	0.1 mg	60571-01	$159

520 MMP FRET Substrate IX QXL™ 520 - RPLALWRK(5 - FAM) - NH2	0.1 mg	60576-01	$159

520 MMP FRET Substrate V 5 - FAM - PLGL - Dap(QXL™ 520) - AR - NH2	0.1 mg	60572-01	$159

520 MMP FRET Substrate VI QXL™ 520 - PLGMWSRK(5 - FAM) - NH2	0.1 mg	60573-01	$159

520 MMP FRET Substrate VII QXL™ 520 - PYAYWMRK(5 - FAM) - NH2	0.1 mg	60574-01	$159

520 MMP FRET Substrate VIII QXL™ 520 - RPKPLA - Nva - WK(5 - FAM) - NH2	0.1 mg	60575-01	$159

520 MMP FRET Substrate X QXL™ 520 - PLAYWARK(5 - FAM) - NH2	0.1 mg	60577-01	$159

520 MMP FRET Substrate XI 5 - FAM - P - Cha - G - Nva - HA - Dap(QXL™ 520) - NH2	0.1 mg	60578-01	$159

520 MMP FRET Substrate XII 5 - FAM - RPKPYA - Nva - WM - K(QXL™ 520) - NH2	0.1 mg	60579-01	$159

520 MMP FRET Substrate XIII 5 - FAM - RPKPVE - Nva - WRK(QXL™ 520) - NH2	0.1 mg	60580-01	$159

520 MMP FRET Substrate XIV QXL™ 520 - γ - Abu - P - Cha - Abu - Smc - HA - Dab(5 - FAM) - AK - NH2 (Smc=S - Methyl - L - cysteine)	0.1 mg	60581-01	$159

520 MMP FRET Substrate XV QXL™ 520 - γ - Abu - PQGL - Dab(5 - FAM) - AK - NH2	0.1 mg	60582-01	$159

520 MMP FRET Substrate XVI QXL™ 520 - RPKPQQFWK(5 - FAM) - NH2	0.1 mg	60583-01	$159

520 MMP FRET Substrate XVII QXL™ 520 - KPLA - Nva - Dap(5 - FAM) - AR - NH2	0.1 mg	60554-01	$159

520 MMP FRET Substrate XVII, scrambled QXL520 - Nva - LPKA - Dap(5 - FAM) - AR - NH2	0.1 mg	64456-01	$159

580 MMP FRET Substrate I QXL™ 570 - KPLA - Nva - Dap(5 - TAMRA) - AR - NH2	0.1 mg	60585-01	$159

CTT, Gelatinase Inhibitor CTTHWGFTLC (Disulfide Bridge: 1 - 10)	1 mg	62054	$115

FRETS - VWF73 (Fluorescence - Quenching Substrate for ADAMTS - 13) DRE - Dap(Nma) - APNLVYMVTG - Dpa - PASDEIKRLPGDIQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQR DRE - Dap(Nma) - APNLVYMVTG - Dap(Dnp) - PASDEIKRLPGD IQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQ R	0.1 mg	63728-01	$303

FRETS - VWF73 (Fluorescence - Quenching Substrate for ADAMTS - 13) DRE - Dap(Nma) - APNLVYMVTG - Dpa - PASDEIKRLPGDIQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQR DRE - Dap(Nma) - APNLVYMVTG - Dap(Dnp) - PASDEIKRLPGD IQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQ R	0.5 mg	63728-05	$1149

Mca MMP FRET Peptide Fluorescence Standard I Mca - PL	1 mg	27159	$39

Mca MMP FRET Peptide Fluorescence Standard II Mca - RPKPQ	1 mg	27112	$61

Mca MMP FRET Peptide Fluorescence Standard II Mca - RPKPQ	5 mg	27113	$242

MMP Colorimetric Substrate I Ac - PLG - SCH[CH2CH(CH3)2] - CO - LG - OC2H5	1 mg	27096	$121

MMP Colorimetric Substrate I Ac - PLG - SCH[CH2CH(CH3)2] - CO - LG - OC2H5	5 mg	27097	$484

MMP Peptide Inhibitor I Ac - RCGVPD - NH2	1 mg	27157	$49

MMP Peptide Inhibitor I Ac - RCGVPD - NH2	5 mg	27158	$193

NFF - 2 Mca - RPKPYA - Nva - WM - K(Dnp) - NH2	5 mg	27111	$385

NFF - 3 Mca - RPKPVE - Nva - WR - K(Dnp) - NH2	1 mg	27114	$99

NFF - 3 Mca - RPKPVE - Nva - WR - K(Dnp) - NH2	5 mg	27115	$385

TNO113 DABCYL - (γ - Abu) - P - Cha - Abu - Smc - HA - E(EDANS) - AK - NH2 (Smc=S - Methyl - L - Cysteine)	1 mg	27061	$291

TNO211 DABCYL - (γ - Abu) - PQGL - E(EDANS)AK - NH2	1 mg	25350	$253

TNO211 DABCYL - (γ - Abu) - PQGL - E(EDANS)AK - NH2	5 mg	25350-5	$1017

WAAG - 3R, Aggrecanase (ADAM - TS - 4) FRET Substrate Abz - TEGEARGSVI - Dpa - KK - NH2 Abz - TEGEARGSVI - Dap(Dnp) - KK - NH2	1 mg	60431-1	$237

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