Neuropeptide Y and Analogs

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Peptides > Neuropeptide Y and Analogs

Neuropeptide Y (NPY) is a 36-amino acid widely distributed neuropeptide that mediates physiological effects via the interaction with six different receptors [Y(1)-Y(6)]. NPY plays an important role in the regulation of energy homeostasis. It modulates the sympathetic nervous system to control blood pressure and also plays a role as a physiological stabilizer of neural activity in circuits involved in the regulation of arousal and anxiety. NPY stimulates feeding desire, increases body weight and anabolic hormone levels by activating the NPY-Y(1) and Y(5) receptors in the hypothalamus. It potently stimulates food intake not only by increasing NPY signaling, but by reducing melanocortin signaling. It possesses inhibitory action on the gonadotropic and somatotropic systems and may have an effect on the properties of vascular endothelial cells such as pro-angiogenic effects and potentiation of noradrenaline-induced vasoconstriction. Central administration of NPY has also been shown to decrease sympathetic nervous system activity and to suppress thermogenesis in brown adipose tissue. A high density of NPY receptors in breast and ovarian cancers suggests a role of NPY in tumor biology.
Ref: Parker, E. et al. Eur. J. Pharmacol. 440, 173 (2002); McAlister, ED. and Van Vugt, DA. Can. J. Physiol. Pharmacol. 82, 1128 (2004); Velkoska, E. et al. Am. J. Physiol. Endocrinol. Metab. 2005 Jan 11; Kim, EH. et al. Am. J. Chin. Med. 32, 659 (2004); Bllogowska, A. et al. Gynecol. Endocrinol. 19, 22 (2004); Korner, M. et al. Clin. Cancer Res.10, 8426 (2004); Kask, A. et al. Neurosci. Biobehav. Rev. 26, 259 (2002); Walker, P. et al. Trends Pharmacol. Sci. 12, 111 (1991); Nussdorfer, GG. and Gottardo, G. Horm. Metab. Res. 30, 368 (1998); Hwa, J. et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 277, R1434 (1999); Britton, K. and Southerland, S. Peptides 22, 607 (2001); Husum, H. et al. Neuropharmacol. 39, 1463 (2000); Morton, G. et al. Int. J. Obes. Relat. Metab. Disord. 25, S56 (2001); O’Shea, D. et al. Endocrinol. 138, 196 (1997); Silva, A. et al. Biol. of the Cell 97, 457 (2005).

Product	Size	Catalog #	US$
[D - Arg25] - Neuropeptide Y, human, rat YPSKPDNPGEDAPAEDMARYYSALrHYINLITRQRY - NH2	0.5 mg	24162	$110
[D - Arg25] - Neuropeptide Y, human, rat YPSKPDNPGEDAPAEDMARYYSALrHYINLITRQRY - NH2	1 mg	24161	$165
[D - His26] - Neuropeptide Y, human, rat YPSKPDNPGEDAPAEDMARYYSALRhYINLITRQRY - NH2	0.5 mg	24164	$110
[D - His26] - Neuropeptide Y, human, rat YPSKPDNPGEDAPAEDMARYYSALRhYINLITRQRY - NH2	1 mg	24163	$165
[D - Trp32] - Neuropeptide Y, human, rat YPSKPDNPGEDAPAEDMARYYSALRHYINLIwRQRY - NH2	0.5 mg	24371	$110
[D - Trp32] - Neuropeptide Y, human, rat YPSKPDNPGEDAPAEDMARYYSALRHYINLIwRQRY - NH2	1 mg	24372	$165
[D - Trp34] - Neuropeptide Y, human YPSKPDNPGEDAPAEDMARYYSALRHYINLITRwRY - NH2	0.5 mg	24377	$200
[D - Trp34] - Neuropeptide Y, human YPSKPDNPGEDAPAEDMARYYSALRHYINLITRwRY - NH2	1 mg	24378	$265
[D - Tyr27,36, D - Thr32] - Neuropeptide Y (27 - 36), rat yINLItRQRy - NH2	0.5 mg	24385	$65
[D - Tyr27,36, D - Thr32] - Neuropeptide Y (27 - 36), rat yINLItRQRy - NH2	1 mg	24386	$110
[D - Tyr27,36, D - Thr32] - Neuropeptide Y, human YPSKPDNPGEDAPAEDMARYYSALRHyINLItRQRy - NH2	0.5 mg	24375	$200
[D - Tyr27,36, D - Thr32] - Neuropeptide Y, human YPSKPDNPGEDAPAEDMARYYSALRHyINLItRQRy - NH2	1 mg	24376	$265
[Leu17, D - Trp32] - Neuropeptide Y, human YPSKPDNPGEDAPAEDLARYYSALRHYINLIwRQRY - NH2	0.5 mg	24373	$110
[Leu17, D - Trp32] - Neuropeptide Y, human YPSKPDNPGEDAPAEDLARYYSALRHYINLIwRQRY - NH2	1 mg	24374	$165
[Leu31, Pro34] - Neuropeptide Y, human, rat YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY - NH2	0.5 mg	24365	$110
[Leu31, Pro34] - Neuropeptide Y, human, rat YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY - NH2	1 mg	24366	$165
[Leu31, Pro34] - Neuropeptide Y, porcine YPSKPDNPGEDAPAEDARYYSALRHYINLLTRPRY - NH2	0.5 mg	24369	$110
[Leu31, Pro34] - Neuropeptide Y, porcine YPSKPDNPGEDAPAEDARYYSALRHYINLLTRPRY - NH2	1 mg	24370	$165
[Pro34] - Neuropeptide Y, human, rat YPSKPDNPGEDAPAEDMARYYSALRHYINLITRPRY - NH2	0.5 mg	24367	$110
[Pro34] - Neuropeptide Y, human, rat YPSKPDNPGEDAPAEDMARYYSALRHYINLITRPRY - NH2	1 mg	24368	$165
[Thr30] - Neuropeptide Y, human YPSKPDNPGEDAPAEDMARYYSALRHYINTITRQRY - NH2	0.5 mg	24379	$130
[Thr30] - Neuropeptide Y, human YPSKPDNPGEDAPAEDMARYYSALRHYINTITRQRY - NH2	1 mg	24380	$200
[Tyr(OMe)21] - Neuropeptide Y, human YPSKPDNPGEDAPAEDMARYY(OMe)SALRHYINLITRQRY - NH2	0.5 mg	24381	$115
[Tyr(OMe)21] - Neuropeptide Y, human YPSKPDNPGEDAPAEDMARYY(OMe)SALRHYINLITRQRY - NH2	1 mg	24382	$205
Ac - (Leu28,31) - Neuropeptide Y (24 - 36) Ac - LRHYLNLLTRQRY - NH2	1 mg	61936	$75
GR231118	0.5 mg	24418	$165
GR231118	1 mg	24419	$275
Neuropeptide Y (1 - 24) amide, human, rat YPSKPDNPGEDAPAEDMARYYSAL - NH2	0.5 mg	22472	$65
Neuropeptide Y (1 - 24) amide, human, rat YPSKPDNPGEDAPAEDMARYYSAL - NH2	1 mg	22473	$110
Neuropeptide Y (13 - 36), human, rat PAEDMARYYSALRHYINLITRQRY - NH2	0.5 mg	22919	$65
Neuropeptide Y (13 - 36), human, rat PAEDMARYYSALRHYINLITRQRY - NH2	1 mg	22483	$110
Neuropeptide Y (13 - 36), human, rat PAEDMARYYSALRHYINLITRQRY - NH2	5 mg	22482	$440
Neuropeptide Y (13 - 36), human, rat , FAM - labeled FAM - PAEDMARYYSALRHYINLITRQRY - NH2	0.5 mg	61196	$165
Neuropeptide Y (13 - 36), human, rat , TAMRA - labeled TAMRA - PAEDMARYYSALRHYINLITRQRY - NH2	0.5 mg	61197	$220
Neuropeptide Y (2 - 36), human, rat PSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY - NH2	0.5 mg	22474	$110
Neuropeptide Y (2 - 36), human, rat PSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY - NH2	1 mg	22475	$195
Neuropeptide Y (2 - 36), porcine PSKPDNPGEDAPAEDLARYYSALRHYINLITRQRY - NH2	0.5 mg	22476	$110
Neuropeptide Y (2 - 36), porcine PSKPDNPGEDAPAEDLARYYSALRHYINLITRQRY - NH2	1 mg	22477	$195
Neuropeptide Y (22 - 36), porcine SALRHYINLITRQRY - NH2	0.5 mg	22921	$65
Neuropeptide Y (22 - 36), porcine SALRHYINLITRQRY - NH2	1 mg	22489	$110
Neuropeptide Y (22 - 36), porcine SALRHYINLITRQRY - NH2	5 mg	22488	$440
Neuropeptide Y (3 - 36), human, rat SKPDNPGEDAPAEDMARYYSALRHYINLITRQRY - NH2	0.5 mg	22478	$110
Neuropeptide Y (3 - 36), human, rat SKPDNPGEDAPAEDMARYYSALRHYINLITRQRY - NH2	1 mg	22479	$195
Neuropeptide Y (3 - 36), human, rat, FAM - labeled FAM - SKPDNPGEDAPAEDMARYYSALRHYINLITRQRY - NH2	0.1 mg	61194	$200
Neuropeptide Y (3 - 36), human, rat, TAMRA - labeled TAMRA - SKPDNPGEDAPAEDMARYYSALRHYINLITRQRY - NH2	0.1 mg	61195	$240
Neuropeptide Y (3 - 36), porcine SKPDNPGEDAPAEDLARYYSALRHYINLITRQRY - NH2	0.5 mg	22480	$110
Neuropeptide Y (3 - 36), porcine SKPDNPGEDAPAEDLARYYSALRHYINLITRQRY - NH2	1 mg	22481	$195
Neuropeptide Y(13 - 36), porcine PAEDLARYYSALRHYINLITRQRY - NH2	1 mg	22484	$110
Neuropeptide Y(13 - 36), porcine Neuropeptide Y(13 - 36), porcine	5 mg	22485	$440
Neuropeptide Y(18 - 36), porcine ARYYSALRHYINLITRQRY - NH2	0.5 mg	22920	$65
Neuropeptide Y(18 - 36), porcine ARYYSALRHYINLITRQRY - NH2	1 mg	22487	$110
Neuropeptide Y(18 - 36), porcine ARYYSALRHYINLITRQRY - NH2	5 mg	22486	$440
Neuropeptide Y, biotinylated, human Biotin - YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY - N H2	0.5 mg	24383	$195
Neuropeptide Y, biotinylated, human Biotin - YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY - N H2	1 mg	24384	$375
Neuropeptide Y, free acid, human, rat YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY	0.5 mg	22466	$110
Neuropeptide Y, free acid, human, rat YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY	1 mg	22467	$165
Neuropeptide Y, human, rat YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY - NH2	0.5 mg	22464	$110
Neuropeptide Y, human, rat YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY - NH2	1 mg	22465	$165
Neuropeptide Y, human, rat, FAM - labeled FAM - YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY - NH2	0.5 mg	23608	$265
Neuropeptide Y, human, rat, FAM - labeled FAM - YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY - NH2	1 mg	23609	$440
Neuropeptide Y, porcine YPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRY - NH2	0.5 mg	22470	$110
Neuropeptide Y, porcine YPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRY - NH2	1 mg	22471	$165
Neuropeptide Y - Lys(Biotin), FAM - labeled FAM - YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYK(Bio tin)	0.5 mg	23626	$330
Neuropeptide Y - Lys(Biotin), FAM - labeled FAM - YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYK(Bio tin)	1 mg	23627	$550
Neuropeptide Y - Lys(Biotin), human, rat YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYK(Biotin)	0.5 mg	23644	$230
Neuropeptide Y - Lys(Biotin), human, rat	1 mg	23645	$385
ß - Neuroprotectin aDLIAYL - NH2	1 mg	22490	$45
ß - Neuroprotectin aDLIAYL - NH2	5 mg	22491	$120

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