Prolactin is involved in the development of the mammary glands and the promotion of milk synthesis in mammals. Prolactin-releasing peptide (PrRP), expressed specifically in the human pituitary is identified in the hypothalamus as a potent prolactin-releasing factor for anterior pituitary cells. This peptide may play a role in the control of food intake, stress response and nociception. PrRP is a member of the RFamide peptide family and is an endogenous ligand for the orphan G protein-coupled receptor (GPCR), hGR3.
Ref: Hinuma S. et al. Nature(Lond) 393, 272 (1998); Engstrom, M. et al. J. Pharmacol. Exp. Ther. 305, 825 (2003); Kimura, A. et al. J. Biol. Chem. 275, 3667 (2000); Chartrel, N. et al. Proc. Natl. Acad. Sci. USA 100, 15247 (2003).