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Secretin is a 27-amino acid gastrointestinal peptide hormone that has been implicated in numerous regulatory events involving the pancreas, biliary tree, stomach, nerves and kidney. It regulates pancreatic exocrine secretion of fluid and bicarbonate, gastric acid secretion and gastric motility, as well as the cardiac and neural activity. The presence of secretin and its receptor in the central nervous system is well documented. Secretin activates visceral brain regions in the rat including areas found to be abnormal in autism. Consequently, secretin-like substances have been used in attempts to treat autism. Two molecular forms of secretin exist in tissue and plasma: fully processed secretin [secretin-(1-27)-amide] and its immediate precursor, secretin-Gly. Carboxy-terminally extended forms of secretin produced during post-translational processing of preprosecretin are equipotent with fully processed secretin for stimulating pancreatic secretion.
Ref: Chey, WY. and TM. Chang, J. Gastroenterol. 38, 1025 (2003); Chey, WY. and TM. Chang, J. Physiol. Pharmacol. 54, 105 (2003); Solomon, T. et al. Am. J. Physiol. Gastrointest. Liver Physiol. 280, G88 (2001); Ulrich, C. et al. Gastroenterol. 114, 382 (1998); Ulrich, C. et al. Am. J. Physiol. Gastrointest. Liver Physiol. 275, G1437 (1998); Welch, M. et al. Cell Mol. Neurobiol. 23, 817 (2003).
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Size |
Catalog # |
US$ |
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Secretin, human
HSDGTFTSELSRLREGARLQRLLQGLV - NH2 |
1 mg |
20767 |
$231 |
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 |
Secretin, rat
HSDGTFTSELSRLQDSARLQRLLQGLV - NH2 |
1 mg |
60677 |
$220 |
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