Peptides  >  Substance P and Analogs
Substance P, also known as neurokinin 1, belongs to the tachykinin neuropeptide family and is a neuropeptide that functions as a neurotransmitter and a neuromodulator. It is an 11-amino acid polypeptide with the sequence generated from a glycine-extended precursor protein by endothelin-converting enzyme. In the central nervous system, Substance P is associated with the regulation of mood disorders, anxiety, stress, reinforcement, neurogenesis, neurotoxicity and pain. In the digestive tract, Substance P, along with some other tachykinins, are neurotransmitters that regulate motor activity, secretion of ions and fluid, as well as vascular functions. In airway sensory nerves, the release of Substance P and nitric oxide modulates airway functions. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1-receptor, NK1R) that belongs to the tachykinin receptor sub-family of GPCRs.

Ref: Leeman, SE. and EA. Mroz, Life Sci. 15, 2033 (1974)); Jeng, A. et al. J. Biol. Chem. 272, 14666 (1997); Wiesenfeld-Hallin, Z. and XJ. Xu, Regul. Pept. 46, 165 (1993).
 Product Size Catalog # US$  
[Pro9] - Substance P
RPKPQQFFPLM - NH2
RPKPQQFFPLM - NH2
1 mg 60500-1 $61
[Succinyl - Asp6, NMePhe8] - Substance P (6 - 11), Senktide
Suc - DF - (NMeF) - GLM - NH2
Suc - DF - (NMeF) - GLM - NH2
1 mg 22886 $49
[Succinyl - Asp6, NMePhe8] - Substance P (6 - 11), Senktide
Suc - DF - (NMeF) - GLM - NH2
Suc - DF - (NMeF) - GLM - NH2
5 mg 22887 $193
Biotin - Substance P
Biotin - RPKPQQFFGLM - NH2
Biotin - RPKPQQFFGLM - NH2
1 mg 27071 $121
Biotin - Substance P
Biotin - RPKPQQFFGLM - NH2
Biotin - RPKPQQFFGLM - NH2
5 mg 27072 $484
Scyliorhinin I, Scy I, Shark Substance P Related Peptide
AKFDKFYGLM
AKFDKFYGLM
1 mg 60603-1 $137
Substance P
RPKPQQFFGLM - NH2
RPKPQQFFGLM - NH2
1 mg 24279 $17
Substance P
RPKPQQFFGLM - NH2
RPKPQQFFGLM - NH2
5 mg 24280 $71
Substance P (8 - 11)
FGLM - NH2
FGLM - NH2
1 mg 61694 $49
Substance P, FAM - labeled
FAM - RPKPQQFFGLM - NH2
FAM - RPKPQQFFGLM - NH2
1 mg 61201 $225
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