The cellular location of Basic Fibroblast Growth Factor (bFGF) changes during development, suggesting the multiple and evolving roles it plays. bFGF participates in the process of wound healing, tissue repair, in the survival, proliferation and differentiation of immature neural cells. It has mitogenic and angiogenic properties and is actively involved in inflammatory bowel disease processes. bFGF and its receptors are expressed by granulosa cells (GCs) of healthy follicles at all stages of development. bFGF prevents GC apoptosis. It regulates intracellular free calcium through a PKC-dependent mechanism. De-regulation of bFGF expression leads to a number of pathological conditions involving angiogenesis, vascular smooth muscle cell proliferation and solid tumor growth.