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Phospholipase A2s (PLA2) are a family of esterases that initiate the arachidonic acid cascade, resulting in the production of numerous inflammatory mediators. Lipocortins are inhibitors of PLA2. Peptides corresponding to a region of high amino-acid sequence similarity between uteroglobin and lipocortin I have potent PLA2 inhibitory activity. Several synthetic peptides corresponding to the region of highest similarity were designed by Miele, L. et al. The most effective anti-inflammatory nonapeptides, termed antiflammins (AFs) correspond to uteroglobin residues 39–47 and lipocortin-1 residues 246–254. Both peptides are PLA2 inhibitors in-vitro and are effective in a classic model of acute inflammation in carrageenan-induced rat footpad edema. The nonapeptides have anti-inflammatory effects in-vitro and in-vivo.
Ref: Sohn, J. et al. Clin. Invest. 111, 121 (2003); Li, Q. et al. Ocul. Immunol. Inflamm. 6, 65 (1998); Marastoni, M. et al. Arzneimittelforschung 41, 240 (1991); Flower, R. and G. Blackwell, Nature. 278, 456 (1979); Miele, L. Clin. Invest. 111, 19 (2003); Miele, L. et al. Nature 335, 726 (1988).
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| Product |
Size |
Catalog # |
US$ |
|
C5a Receptor Agonist, mouse, human
FKP - (D - Cha) - Cha - r |
1 mg |
65121 |
$77 |
 |
 |
Linear C5a Receptor Antagonist, mouse, human
FKP - (D - Cha) - Wr |
1 mg |
65122 |
$99 |
|
|
WP9QY, TNF - alpha Antagonist
YCWSQYLCY (Disulfide bridge: 2 - 8) |
1 mg |
62621 |
$132 |
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