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The C3a anaphylatoxin is a 78-amino-acid peptide derived from the proteolytic cleavage of the complement protein C3. It mediates a variety of proinflammatory and immunoregulatory functions through its binding to the seven-transmembrane segment G-protein-coupled C3a receptor (C3aR). C3a induces smooth muscle contraction, increases vascular permeability, arachidonic acid metabolism, cytokine release, cellular degranulation and chemotaxis. C3a are involved in microbial host defense, immune regulation and protection against toxic insult. C3a enhance granulocyte adhesion to endothelial and epithelial cell monolayers. Anaphylatoxin C3a inhibits the generation of leukocyte inhibitory factor activity by human mononuclear leukocytes and T lymphocytes cultured with the mitogens in-vitro.
Ref: Reca, R. et al. Blood 101, 3784 (2003); Gao, J. et al. J. Biol. Chem. 278, 37902 (2003); Kalant, D. et al. J. Biol. Chem 278, 11123 (2003); Payan, DG. et al. J. Exp. Med. 156, 756 (1982); Daffern, PJ. et al. J. Exp. Med. 181, 2119 (1995); Takabayashi, T. et al. J. Immunol. 156, 3455 (1996); Hartmann, K. et al. Blood. 89, 2863 (1997); Jagels, M. et al. Immunopharmacol. 46, 209 (2000). |
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| Product |
Size |
Catalog # |
US$ |
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[Trp63, 64] - C3a (63 - 77)
WWGKKYRASKLGLAR |
1 mg |
61119 |
$105 |
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C3a (70 - 77)
ASHLGLAR |
1 mg |
61118 |
$39 |
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