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The core histones (H2A, H2B, H3 and H4) act as spools around which DNA winds. Covalent modification on the amino terminal of the core histones through de/acetylation, de/methylation and de/phosphorylation affect chromatin structure and exquisitely regulate gene expression.1-3 Histone hyperacetylation is correlated with increased transcription, whereas hypoacetylation correlates with transcriptional repression.2
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1. Jenuwein, T. and CD. Allis Science 293, 1074 (2001).
2. Sterner, DE. et al. Microbiol. Mol. Biol. Rev. 64, 435 (2000).
3. Lachner, M. et al. J. Cell Sci. 116, 2117 (2003).
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