Amyloid Peptides - The World's Most Comprehensive Collection


Amyloid Peptides

AnaSpec has been providing -Amyloid peptides to leading Alzheimers researchers for almost 10 years. As interest in amyloid peptides continues to grow, AnaSpec has developed an extensive selection of catalog amyloid peptides to match that interest. Optimally equipped with expertise in both peptide synthesis and detection technologies, AnaSpec is proud to offer the worlds most comprehensive collection of amyloid peptides.

-Amyloid (A) peptides, made up of long, insoluble ordered fibers, are glycoproteins deposited extracellularly in tissues in amyloidosis. These peptides are generated as cleavage products from the membrane protein, Amyloid Precursor Protein (APP) by two proteases, -secretase and γ-secretase. As are amphiphilic peptides with a hydrophilic N-terminal domain (residues 1 to 28) and a hydrophobic C-terminal (residues 29 to 40), the latter corresponding to a part of the transmembrane domain of APP. These insoluble amyloid deposits found in Alzheimers diseased brains have been the subject of increased interest for Alzheimers treatment (reviewed in 1, 2).

Our comprehensive collection includes:

  • As of various lengths
  • Amino acid-substituted As
  • Dye-labeled As
  • Biotin-labeled As
  • Sodium forms
  • HCl forms
  • TFA salt forms(Standard form, unless otherwise specified
  • )
  • iAb5p and other-A inhibitors
  • Humanins
  • Secretase fluorescent resonance energy transfer (FRET) substrates and inhibitors


  • For a complete listing of AnaSpec's amyloid peptides, click here.

    References:
    1. Selkoe DJ. Nature 399, A23 (1999).
    2. Suh, Y-H. and F. Checler. Pharma. Rev. 54, 469 (2002).
    3. Suzuki, N. et al. Science 264, 1336 (1994).
    4. Iwatsubo, T. et al. Neuron 13, 45 (1994).
    5. Citron, M. et al. Nature (London) 360, 672 (1992).