β-Amyloid & Tau - Peptides, Antibodies, Assays & Dyes

In Alzheimer's disease (AD), the major pathological hallmarks are β-sheet aggregates of β-amyloid peptides in senile plaques and hyperphosphorylated tau protein in neurofibrillary tangles (NFT).1-2 Harnessing over 15+ years' worth of experience and a multi-level technology platform that includes β-amyloid and Tau peptides, antibodies, dyes and assay kits, AnaSpec is one of the world's trusted sources of integrated solutions specifically designed for AD research. Our offering ranges from the world's largest collection of β-amyloid peptides to the industry's highly sensitive assays for determining human β-Amyloid (1-42) and β-Amyloid (1-40) amount in cell and tissue lysate as well as in body fluids; and from the largest collection of anti-Tau antibodies (both phospho and non-phospho specific) to dyes and assays for labeling of amyloid fibrils. As well, a sensitive, fluorimetric assay for determining amyloid degrading proteases activity was recently released, the SensoLyte® Neprilysin Activity Assay.

AnaSpec offers:


Peptides

Antibodies

Assay Kits & Dyes

Below are partial listings of the many β-Amyloid and Tau products that AnaSpec provides:

Beta-Amyloid Peptides

Product Size

Catalog #

Beta-Amyloid (1-42)
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

0.5 mg
1 mg
5 mg
25 mg

AS-24224
AS-20276
AS-20276-5
AS-20276-25

Beta-Amyloid (1-40)
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV

0.5 mg
1 mg
5 mg

AS-24235
AS-24236
AS-24236-5

Beta-Amyloid (1-42), HiLyte™ Fluor 488-labeled
HiLyte™ Fluor 488-DAEFRHDSGYEVHHQKLVFFAE
DVGSNKGAIIGLMVGGVVIA

0.1 mg

AS-60479-01

ClearPoint™ beta-Amyloid (1-15), 13C, 15N-labeled at Ala, Arg & Gly
D-A*-EF-R*-HDS-G* -YEVHHQ [A*=A(U - 13C3, 15N); R*=R(U-13C6, U-15N4); G*=G(U-13C2, 15N)]

50 ug

AS-64804


AD brain section probed with Ab (1-42), HiLyte™ Fluor 488 labeled peptide (Cat # 60479-01). Image is courtesy of Dr. J-P Guo in Dr. Patrick L. McGeer's lab, University of British Columbia, Vancouver, Canada.


Tau Peptides

Product

Size

Catalog #

Tau Peptide (45 - 73) (Exon 2/Insert 1 domain)
ESPLQTPTEDGSEEPGSETSDAKSTPTAE

1 mg
5 mg

AS-65431-1
AS-65431-5

Tau Peptide (74 - 102) (Exon 3/Insert 2 domain)
DVTAPLVDEGAPGKQAAAQPHTEIPEGTT

1 mg
5 mg

AS-65432-1
AS-65432-5

Tau Peptide (244 - 274) (Repeat 1 domain)
Ac-QTAPVPMPDLKNVKSKIGSTENLKHQPGGGK

1 mg
5 mg

AS-65433-1
AS-65433-5

Tau Peptide (275 - 305) (Repeat 2 domain)
VQIINKKLDLSNVQSKCGSKDNIKHVPGGGS

1 mg
5 mg

AS-65434-1
AS-65434-5

Tau Peptide (306 - 336) (Repeat 3 domain)
VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQ

1 mg
5 mg

AS-65435-1
AS-65435-5

Tau Peptide (337 - 368) (Repeat 4 domain)
VEVKSEKLDFKDRVQSKIGSLDNITHVPGGGN

1 mg
5 mg

AS-65436-1
AS-65436-5

Tau Antibodies

Product

Size

Catalog #

Anti-Tau Antibody (GlcNAc Ser400), Rabbit Polyclonal

50 µg

AS-55945

Anti-Tau Antibody (Ser400), Rabbit Polyclonal

50 µg

AS-55944

Anti-Tau Antibody (Acetyl K280), Rabbit Polyclonal 50 µg AS-56077
Anti-Tau Antibody (K280), Rabbit Polyclonal 50 µg AS-56078



Assay Kits for AD Research

Product

Catalog #

SensoLyte® Anti-Human β-Amyloid (1 - 40) Quantitative ELISA *Colorimetric*
Detects as low as 2 pg/ml (13 fmoles/ml) of human beta-Amyloid (1-42)

AS-55551

SensoLyte® Anti-Human β-Amyloid (1 - 42) Quantitative ELISA *Colorimetric*
Detects as low as 2 pg/ml (13 fmoles/ml) of human beta-Amyloid (1-40)

AS-55552

Email biology@anaspec.com or chemistry@anaspec.com for technical information or general inquiries of our products.

References
1.Khachaturian, ZS. Arch. Neurol. 42, 1097 (1985).
2.Mirra, SS. et al. Neurol. 41, 479 (1991).