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| Calcium Homeostasis - PTH & Calcitonin |
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Calcium Homeostasis - PTH & Calcitonin
Calcium homeostasis is finely regulated by Parathyroid Hormone (PTH), Calcitonin and Vitamin D. Briefly, a decrease in calcium concentration in the blood triggers the release of PTH, an 84-amino acid hormone, from the parathyroid glands. An increase, however, causes the release of Calcitonin, a 32-amino acid protein from the thyroid parafollicular cells (C-cells).
AnaSpec carries a wide range of peptide solutions to support researchers working with Ca2+ metabolism.
For scientists in need of PTH or calcitonin peptide analogs containing unusual amino acids, AnaSpec carries a wide range of unusual amino acids that will facilitate your research. Contact us at service@anaspec.com for information about custom peptide synthesis.
PTH (1-34)
- Human, Bovine, and Rat - the amino-terminal PTH (1-34) fragment satisfies the structural requirements for all known biological activities of parathyroid hormone PTH(1-84)]2
- Biotinylated, FAM-labeled, and Lys-biotin-labeled - used as probes in studies such as characterization of parathyroid hormone receptors3,4
Parathyroid Hormone Related Protein (PTHrP)
- 1-34, 1-40, and 7-34 peptide fragments - responsible for most of humoral hypercalcemia of malignancy (HHM)5
Calcitonin
Other Calcitonin related peptides:
To request AnaSpec’s newest 2006-2008 Peptides Catalog, click here
References:
- Khan, MM. and JP. Desborough, Pharmacology 19, 1 (2005).
- Stevenson, RW and JA Parsons, J. Endo. 97, 21 (1983).
- Newman, W. et al. J. Biol. Chem. 264, 16359 (1989).
- Brennan, DP. and MA. Levine, J. Biol. Chem. 262, 14795 (1987).
- Broadus, AE. et al. N. Engl. J. Med. 319, 556 (1988).
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