Calcium Homeostasis - PTH & Calcitonin


Calcium Homeostasis - PTH & Calcitonin

Calcium homeostasis is finely regulated by Parathyroid Hormone (PTH), Calcitonin and Vitamin D. Briefly, a decrease in calcium concentration in the blood triggers the release of PTH, an 84-amino acid hormone, from the parathyroid glands. An increase, however, causes the release of Calcitonin, a 32-amino acid protein from the thyroid parafollicular cells (C-cells).

AnaSpec carries a wide range of peptide solutions to support researchers working with Ca2+ metabolism.

For scientists in need of PTH or calcitonin peptide analogs containing unusual amino acids, AnaSpec carries a wide range of unusual amino acids that will facilitate your research. Contact us at service@anaspec.com for information about custom peptide synthesis.

PTH (1-34)
  • Human, Bovine, and Rat - the amino-terminal PTH (1-34) fragment satisfies the structural requirements for all known biological activities of parathyroid hormone PTH(1-84)]2
  • Biotinylated, FAM-labeled, and Lys-biotin-labeled - used as probes in studies such as characterization of parathyroid hormone receptors3,4

Parathyroid Hormone Related Protein (PTHrP)
  • 1-34, 1-40, and 7-34 peptide fragments - responsible for most of humoral hypercalcemia of malignancy (HHM)5

Calcitonin
Other Calcitonin related peptides:
To request AnaSpecís newest 2006-2008 Peptides Catalog, click here

References:

  1. Khan, MM. and JP. Desborough, Pharmacology 19, 1 (2005).
  2. Stevenson, RW and JA Parsons, J. Endo. 97, 21 (1983).
  3. Newman, W. et al. J. Biol. Chem. 264, 16359 (1989).
  4. Brennan, DP. and MA. Levine, J. Biol. Chem. 262, 14795 (1987).
  5. Broadus, AE. et al. N. Engl. J. Med. 319, 556 (1988).