Fmoc-Ser & Thr (GlcNac) for PTM Research
Untitled Document
Fmoc-Ser(β-D-GlcNAc(Ac)3)-OH and Fmoc-Thr(β-D-GlcNAc(Ac)3)-OH are useful building blocks for syntheses of peptides containing the GlcNAc modification of serines and threonines, respectively. The addition of β-N-acetylglucosamine (GlcNAc) to the hydroxyl group of serines or threonines generating O-linked β-N-acetylglucosamine (O-GlcNAc) serines or threonines is one kind of post-translational modification (PTM) found in proteins.1,2  This O-GlcNAcylation reversible modification directly competes with phosphorylation of these two amino acids.2,3
AnaSpec provides a suite of PTM amino acid building blocks to the epigenetic research community. These Fmoc amino acids that we offer to our customers are the very same amino acids that we use daily in our own manufacturing facilities.  
PTM Amino Acids

To view AnaSpec's extensive collection of unusual amino acids, please click here.
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Glycosylated (GlcNac) Serine & Threonine

Product

Size

Catalog #

Fmoc-Ser(β-D-GlcNAc(Ac)3)-OH NEW
CAS# 160067-63-0

Fmoc-Ser(β-D-GlcNAc(Ac)3)-OH

100 mg

250 mg

 

65495-100

65495-250

 

Fmoc-Thr(β-D-GlcNAc(Ac)3)-OH NEW
CAS# 160168-40-1

Fmoc-Thr(β-D-GlcNAc(Ac)3)-OH

100 mg

250 mg

65494-100

65494-250

Phosphorylated Serines

Product

Size

Catalog #

Fmoc-Ser[PO(OBzl)-OH]-OH
N-α-Fmoc-O-benzyl-L–phosphoserine
CAS# 158171-14-3

Fmoc-Ser[PO(OBzl)-OH]-OHN-a-Fmoc-O-benzyl-L–phosphoserineCAS# 158171 - 14 - 3

1 g

5 g

25 g

50 g

100 g

1 cartridge

10 cartridges

20419

20420

20420-25

20420-50

20420-100

29869

23219

Fmoc-D-Ser[PO(OBzl)-OH]-OH
N-α-Fmoc-O-benzyl-D-phosphoserine

Fmoc-D-Ser[PO(OBzl)-OH]-OHN-a-Fmoc-O-benzyl-D-phosphoserine

1 g

5 g

60083-1

60083-5

Phosphorylated Threonines

Product

Size

Catalog #

Fmoc-Thr[PO(OBzl)-OH]-OH
N-α-Fmoc-O-benzyl-L-phosphothreonine
CAS# 175291-56-2

Fmoc-Thr[PO(OBzl)-OH]-OHN-a-Fmoc-O-benzyl-L-phosphothreonine       CAS# 175291-56-2

1 g

5 g

25 g

50 g

100 g

20835

20836

20836-25

20836-50

20836-100

Fmoc-D-Thr[PO(OBzl)-OH]-OH
N-α-Fmoc-O-benzyl-D-phosphothreonine

Fmoc-D-Thr[PO(OBzl)-OH]-OHN-a-Fmoc-O-benzyl-D-phosphothreonine

1 g

5 g

60557-1

60557-5

Phosphorylated D-Tyrosine

Fmoc-D- Tyr[PO(OBzl)OH] -OH
N-α-Fmoc-O-benzyl-D-phosphotyrosine

Fmoc-D-Tyr[PO(OBzl)OH]-OH

1 g

5 g

61428-1

61428-5

Acetylated Lysines

Product

Size

Catalog #

Fmoc-Lys(Ac)-OH
N-α-Fmoc-N-ε-acetyl-L-lysine
CAS# 159766-56-0

Fmoc-Lys(Ac)-OHN-a-Fmoc-N-e-acetyl-L-lysine, CAS# 159766-56-0 1 g

5 g

22502

23356

Boc-Lys(Ac)-OH
N-α-t-Boc-N-ε-acetyl-L-lysine
CAS# 6404-26-8

Boc-Lys(Ac)-OHN-a-t-Boc-N-e-acetyl-L-lysine,CAS# 6404-26-8

1 g

5 g

23084

23085


Methylated (mono, di & tri) Lysines

Product

Size

Catalog #

Fmoc-Lys(Me, Boc)-OH
N-α-Fmoc-N-ε,ε-t-Boc-methyl-L-lysine

Fmoc-Lys(Me, Boc)-OHN-a-Fmoc-N-e,e-t-Boc-methyl-L-lysine

0.25 g

1 g

5 g

60327-025

60327-1

60327-5

Fmoc-Lys(Me)2-OH • HCl
Fmoc-Lys(Me)2-OH chloride; Fmoc-Lys(Me)2–OH
CAS# 252049-10-8

Fmoc-Lys(Me)2-OH • HClFmoc-Lys(Me)2-OH chloride; Fmoc-Lys(Me)2–OHCAS# 252049-10-8

250 mg

1 g

28211

28212

Boc-Lys(Me)2-OH
Boc-Nε,ε -dimethyl-L-lysine

Boc-Lys(Me)2-OHBoc-Ne,e -dimethyl-L-lysine

250 mg

1 g

60025-025

60025-1

Fmoc-Lys(Me3)-OH chloride
CAS# 201004-29-7

Fmoc-Lys(Me3)-OH chlorideCAS# 201004-29-7

250 mg

500 mg

1 g

53099-F025

53099-F05

53099-F1


Methylated (mono & di- symmetrical & asymmetrical) Arginines

Product

Size

Catalog #

Fmoc-Arg(Me)(Pbf)–OH
CAS# 135616-49-7

Fmoc-Arg(Me)(Pbf)–OHCAS# 135616-49-7

0.25 g

1 g

65281-025

65281-1

Fmoc-Arg(Me)2-OH (asymmetrical)
Fmoc-Nω,ω-dimethyl-L-arginine (asymmetrical)
CAS# 268564-10-9

Fmoc-Arg(Me)2-OH (asymmetrical)Fmoc-N?,?-dimethyl-L-arginine (asymmetrical)CAS# 268564-10-9

250 mg

1 g

26218-F025

26218-F1

Fmoc-Arg(Me)2-OH (symmetrical)
Fmoc-Nω,ω-dimethyl-L-arginine (symmetrical)

Fmoc-Arg(Me)2-OH (symmetrical)Fmoc-N?,?-dimethyl-L-arginine (symmetrical)

250 mg

1 g

26217-F025

26217-F1

Citrullinated (Deiminated) Arginines

Product

Size

Catalog #

Fmoc-DL-citrulline

Fmoc-DL-citrulline

1 g

5 g

26216-F1

26216-F5

Boc-DL-citrulline

Boc-DL-citrulline

1 g

5 g

26216-B1

26216-B5

Fmoc-L–citrulline
CAS# 133174-15-9

Fmoc-L–citrullineCAS# 133174-15-9

1 g

5 g

21359

21361

Boc-L–citrulline
CAS# 45234-13-7

Boc-L–citrullineCAS# 45234-13-7

1 g

5 g

26215-B1

26215-B5

 

 

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Reference:

  1. Love, DC. & JA. Hanover, Sci STKE 2005, re 13 (2005).
  2. Hart, GW. et al. Nature 446, 1017 (2007).
  3. Hart, GW. et al. Glycobiol 6, 711 (1996).