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| Fluorinated Building Blocks |
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Fluorinated Building Blocks Produce Molecules with Enhanced Physiological Activities
The substitution of the fluorine in place of hydrogen in building blocks, such as amino acids, has produced molecules with enhanced physiological activities (1-2). Some of these are antibacterial, antihypertensive and antitumoral (3). One reason for the enhanced activity is that fluorine forms a strong covalent bond with a carbon atom, which in peptides creates hyper-stable protein folds that render fluoro amino acid-containing peptides resistant to metabolic transformation (2, 4). The electronegativity of fluorine affects the pH of the neighboring groups, which in turn causes an overall change in the stability and reactivity of a molecule (2).
AnaSpec, a worldwide provider of integrated proteomics solutions, offers a wide collection of fluorinated amino acids.
Selected Listing of Fluorinated Amino Acids
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For a complete listing,
click here.
Contact AnaSpec at techsupport@anaspec.com if you cannot find the building blocks you want or are looking for building blocks without the Fmoc or Boc protection.
For more information, visit www.anaspec.com
References:
1. Welch, JT. Tetrahedron 43, 3123 (1987).
2. Sutherland, A. and CL. Willis. Nat. Prod. Rep. 17, 621 (2000).
3. Davis, FA. et al. J. Org. Chem. 64, 6931 (1999).
4. Yoder, NC. And K. Kumar. Chem. Soc. Rev. 31, 335 (2002).
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