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| Insulin Receptors Antibodies- New Optimized Size |
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Insulin Receptors Antibodies- New Optimized Size
The insulin receptor is a transmembrane receptor that belongs to the tyrosine kinase receptors class. It is a heterotetrameric glycoprotein composed of disulfide-linked subunits in a β-α-α-β configuration. This transmembrane receptor consists of 95kDa β-subunit, a single transmembrane domain, and 135kDa α-subunit, which is completely extracellular. Binding of insulin to the receptor results in stimulation of its intrinsic kinase activity. The insulin receptor mediates insulin action through the phosphorylation of substrate proteins. Insulin receptor becomes phosphorylated as a response to stimulation of cells by insulin, insulin-like growth factor (IGF-I) and interleukin 4. The major substrates of the insulin receptor kinase are the insulin receptor substrate (IRS) family of proteins, IRS-1, IRS-2, IRS-3, IRS-4. Recently, two more signaling proteins, IRS5/DOK4 and IRS6/DOK5, have been identified as potentially new members of the IRS family. The insulin receptor substrate-1 (IRS-1), a 170-185 kDa protein, is a major substrate of the insulin receptor. IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues.
AnaSpec is pleased to showcase our line of insulin receptor antibodies; ideal for addressing your research needs in protein phosphorylation, glucose metabolism, cancer, and diabetes studies. Rigorously validated on ELISA, and Western Blot or IHC, and offered in an optimized research-grade size, AnaSpec’s insulin receptor antibodies offer premium quality in a cost-effective package.
Click here to request a copy.
| Product | New Size | Catalog# |
| Anti-Insulin NEW | 50 µg | 53585 |
| Anti-Insulin Receptor NEW | 50 µg | 53586 |
| | Anti-IRS-1 NEWInsulin Receptor Substrate-1 (IRS-1) | 50 µg | 53594 |
| Anti-IRS-1 (pSer312), phospho-specific | 50 µg | 28120 |
| Anti-IRS-1 (Paired312), non-phospho-specific | 50 µg | 28121 |
| Anti-IRS-2 (pSer731, phospho-specific | 50 µg | 28122 |
| Anti_IRS-2 (Paired 731), non-phospho-specific | 50 µg | 28123 |
| Anti-IGF-1 NEW Insulin-like growth factor 1 | 50 µg | 53566 |
| Anti-IGF-1 NEWInsulin-like growth factor 2 | 50 µg | 53567 |
Anti-IRS-1
The antibody was raised against a synthetic peptide corresponding to human IRS-1 protein. Species Reactivity: human.
Image: Human colon carcinoma stained with Anti-IRS-1 | 50 µg | 53594 |
Anti-Insulin Receptor
Mouse anti-insulin receptor monoclonal antibody. Species Reactivity: human, cow, pig, rabbit, sheep.
Image: Human pancreas stained with Anti-Insulin receptor. | 50 µg | 53586 |
Anti-Insulin
Mouse anti-insulin monoclonal antibody was raised against swine insulin. Species reactivity: human, rat, cow, pig, and rabbit.
Image: Human pancreas stained with Anti-Insulin antibody. | 50 µg | 53585 |
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Insulin Receptor Related Peptides
One of the world's largest providers of catalog peptides, AnaSpec also carries a number of high-purity insulin receptor (IRS) related peptides.
High Purity
Triple-Stage Validation by Mass Spec and HPLC
May be used as insulin receptor tyrosin kinase substrates |
| Product | Size | Cat. #
| | Insulin Receptor (1142-1153) | 1 mg | 24537
| | Insulin Receptor (1142-1153) | 1mg | 24538
| | Insulin Receptor (1142-1153), phosphorylated (Y1146) | 1 mg | 20292
| | Insulin Receptor (1142-1153), phosphorylated (Y1146) | 5 mg | 24503
| | Insulin Receptor (1142-1153), phosphorylated (Y1146), biotinylated | 1 mg | 23725
| | Insulin Receptor (1142-1153), phosphorylated (Y1146), biotinylated | 5 mg | 23726
| | Insulin Receptor (1142-1153), phosphorylated (Y1146) | 1 mg | 20274
| | Insulin Receptor (1142-1153), phosphorylated (Y1146) | 5 mg | 24501
| | Insulin Receptor (1142-1153), phosphorylated (Y1146), biotinylated | 1 mg | 23727
| | Insulin Receptor (1142-1153), phosphorylated (Y1146), biotinylated | 5 mg | 23728
| | Insulin Receptor (1142-1153), phosphorylated (Y1151) | 1 mg | 20273
| | Insulin Receptor (1142-1153), phosphorylated (Y1151) | 5 mg | 24502
| | Insulin Receptor (1142-1153), phosphorylated (Y1151), biotinylated | 1 mg | 23729
| | Insulin Receptor (1142-1153), phosphorylated (Y1151), biotinylated | 5 mg | 23730
| | Insulin Receptor (1142-1153), phosphorylated (Y1151, Y1150, Y1151) | 1 mg | 20272
| | Insulin Receptor (1142-1153), phosphorylated (Y1151, Y1150, Y1151) | 5 mg | 24500
| | Insulin Receptor (1142-1153), phosphorylated (Y1151, Y1150, Y1151), biotinylated | 1 mg | 23910
| | Insulin Receptor (1142-1153), phosphorylated (Y1151, Y1150, Y1151), biotinylated | 5 mg | 23911
| | Insulin Receptor (1142-1153), amide | 1 mg | 27065
| | Insulin Receptor (1142-1153), amide | 5 mg | 27066
| | Insulin Receptor (1142-1153), biotinylated | 1 mg | 24629
| | Insulin Receptor (1142-1153), biotinylated | 5 mg | 24840
| | Insulin Receptor (1142-1153), amide, biotinylated | 1 mg | 23998
| | Insulin Receptor (1142-1153), biotinylated | 5 mg | 23999
| | Kinase Domain of Insulin Receptor (1) | 1 mg | 24544
| | Kinase Domain of Insulin Receptor (1) | 5 mg | 61765
| | IRS1-derived peptide NEW | 1 mg | 61764
| | Insulin B (9-23) NEW | 1 mg | 61532
| | Proinsulin C-Peptide (31-63), porcine | 0.5 mg | 61129
| | Proinsulin C-Peptide (55-89), human | 0.5 mg | 61130
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