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| Anti-MOG (35-55) IgG Quantitative ELISA Kits |
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For years, AnaSpec has been providing MOG (35-55) and other multiple sclerosis (MS) experimental autoimmune encephalomyelitis
(EAE)-related peptides to researchers world-wide. Now one of the world’s most trusted suppliers of MOG (35-55) peptides is pleased
to present our new line of SensoLyte™ Anti - MOG ELISA Kits - the world’s first and only anti-MOG ELISA kits.
Myelin oligodendrocyte glycoprotein (MOG), a member of the immunoglobulin superfamily, is expressed exclusively in central nervous
system myelin. Recent studies suggest that MOG may function in the completion, compaction, and maintenance of myelin in the
central nervous system.1 Even though MOG physiological function is not entirely understood, studies have correlated the immune
response of MOG to autoimmune mediated demyelination in several species.2 MOG is able to induce encephalitogenic T cell
response, autoantibody response, and produce relapsing-remitting neurological disease with an extensive plaque-like
demyelination.3
Autoantibody response to MOG (35-55) has been observed in multiple sclerosis (MS) patients and MOG (35-55)-induced experimental
autoimmune encephalomyelitis (EAE) mice;4-10 however, the exact pathological role of anti-MOG (35-55) autoantibody is not known
and is currently under vigorous investigation.
SensoLyte™ Anti - MOG ELISA Kits – World’s First & Only
AnaSpec is pleased to announce the release of a family of anti-MOG (35-55) IgG Quantitative ELISA Kits (Mouse/rat) that will help
further the research of MS. These kits are optimized to detect anti-MOG (35-55) mouse/rat IgG and IgG subtypes. Using strips
pre-coated with MOG (35-55) peptide and pre-blocked with BSA, the amount of anti-MOG IgG subtypes in serum or cerebrospinal
fluid can be determined by ELISA and the absorbance read at 450 nm.
Anti-MOG (35-55) Antibody
Rabbit anti-MOG (35-55) polyclonal antibody was raised against a synthetic peptide from the N-terminus corresponding to amino
acids 35-55 of mouse and rat MOG. There is only one amino acid residue difference between the mouse/rat and human MOG (35-55)
peptide. ELISA results show that Anti-MOG (35-55) cross-react with human. The antibodies were also evaluated by Western blot.
Anti-MOG (35-55) Antibody
Related Products:
MOG Peptides
MBP
PLP
Click here to request additional literature
To view a poster entitled “Suppressive Role of CD72 in Experimental Autoimmune Encephalomyelitis” presented by scientists from
AnaSpec and Stanford University at the 2007 American Association of Immunologists at Miami Beach, Florida, please click here.
References:
1. Tzako, AG. et al. Current Medicinal Chem. 12, 1569 (2005).
2. Johns, TQ. et al. J. Neurochem. 72, 1(1999).
3. Karpus, WJ. et al. Methods 29, 362 (2003).
4. Huntington, ND. et al. International Immunology 18, 10 1473(2006).
5. March, AK. et al. J. Neuroimmunology 135, 117 (2003).
6. Slavin, A. et al. Autoimmunity 28, 109 (1998).
7. Ichikawa, M. et al. Cellular Immunology 191, 97 (1999).
8. Robinson, W. et al. Nat. Biotechnology 21, 1033 (2003).
9. Mayo S. et al. Clinical Immunology 118:219-228 (2006).
10. Kennel De March, A. et al. J. Neuroimmunol. 135, 117 (2003).
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