Cathelicidins
are cationic peptides that have broad-range antimicrobial activity.1
These peptides belong to the family of anti-microbial peptides which form
part of the host’s important innate immunity mechanism.2 In humans,
cathelicidins and defensins are expressed in immune cells and at epithelial
surfaces.3-5 hCAP18, human cationic antimicrobial protein, with
a MW of 18 kD, is the only cathelicidin gene found in humans.2
The N-terminus of this protein consists of a cathelin-like region (similar
to the other members of the cathelicidin family) and a C-terminal termed LL-37.6-7
An amphipathic alpha-helical peptide, LL-37
plays an important role in the first line of defense
against local infection and systemic invasion of pathogens at sites of inflammation
and wounds. Cytotoxic to both bacterial and normal eukaryotic cells,
LL-37 is significantly resistant to proteolytic degradation in solution.8-9
Offering
one of the world’s largest collections of catalog peptides, AnaSpec is pleased
to introduce a wide range of structurally diverse cathelicidin peptides, some
of which have not been commercially available until now.
Request AnaSpec’s newest
Peptides catalog
Product |
Size |
Catalog # |
| LL-37; Antimicrobial
Peptide, human
LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES |
1 mg |
61302 |
| LL-37, reverse sequence
SETRPVLNRLFDKIRQVIRKFEKGIKEKSKRFFDGLL |
0.5 mg |
62208 |
| LL-37 pentamide10
LLGNFFRKSKQKIGKQFKRIVQRIKNFFRNLVPRTQS;
more potent than LL-37 |
1 mg |
61309 |
| RL-3710
RLGNFFRKVKEKIGGGLKKVGQKIKDFLGNLVPRTAS;
Rhesus monkey |
0.5 mg |
61313 |
| mCRAMP; mouse11
GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ;
mouse cathelicidin-related antimicrobial peptide |
1 mg |
61305 |
| rCRAMP12
GLVRKGGEKFGEKLRKIGQKIKEFFQKLALEIEQ;
rat cathelicidin-related antimicrobial peptide |
1 mg |
61306 |
| SMAP 29, Sheep Myeloid
Antimicrobial Peptide 2913
RGLRRLGRKIAHGVKKYGPTVLRIIRIAG |
1 mg |
61308 |
| CAP-18; rabbit14
GLRKRLRKFRNKIKEKLKKIGQKIQGLLPKLAPRTDY |
1 mg |
61307 |
| Bactenecin, bovine15
RLCRIVVIRVCR
(Disulfide bridge: 3-11); Proline and arginine rich |
0.5 mg |
61066 |
| Indolicidin16
ILPWKWPWWPWRR-NH2;
tryptophan-rich & found to be an inhibitor
of HIV-1 reverse transcriptase and integrase17 |
1 mg |
60999 |
To
view our complete list of anti-microbial peptides, please click here.
Related
Peptide Products:
·
Defensins
·
Histatins
·
Cecropins
·
Magainins
·
Ovispirins
·
Cathepsin
substrates
References:
1.
Zanetti, M. et al. J. Biol. Chem. 268, 522 (1993).
2. Lehrer, R. and T. Ganz. Curr. Opin.
Immunol. 11, 23 (1999).
3. Ganz, T. Nat. Rev. Immunol. 3, 710 (2003).
4. Zanetti, M. J. Leukoc. Biol. 75, 39 (2004).
5. Chromek, M.
et al. Nature Medicine 12, 636 (2006).
6. Zanetti, M. et al. FEBS Lett.
374, 1 (1995).
7. Sorensen, OE. et al. Blood 97, 3951 (2001).
8. Neville, F. et al. Biophys. J. 90, 1275 (2006)
9.
Oren, Z., et al. Biochem. J. 341, 501(1999).
10.
Zhao, C. et al. Antimicrob. Ag. Chemother.
45, 2695 (2001).
11. Lopez-Garcia,
B. et al. J. Invest. Dermatol. 125, 108 (2005).
12. Termen, S.
et al. Cell. Mol. Life Sci. 60, 536 (2003).
13. Saiman, L et al. Antimicrob. Ag. Chemother. 45, 2838 (2001).
14. Travis, S et al. Infect. Immun. 68, 2748 (2000).
15. Wu, M. and REW Hancock J. Biol. Chem. 274, 29 (1999).
16. Selsted, ME. et al. J. Biol. Chem. 267,
4292 (1992).
17. de Soultrait VR. et al. Curr. Med.
Chem. 10, 1765 (2003).
