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Acetylated & Methylated Lysines – Extensive Selection

Histone Peptides Building Blocks

AnaSpec, one of the world’s largest providers of unusual amino acids, offers acetylated, mono-methylated, di-methylated and tri-methylated Lysine for the synthesis of histone peptides. The use of these building blocks, although not limited to making synthetic histone peptides, provides additional tools for researchers to help unravel the “histone code.”⁵

The lysine-rich amino terminal tail of the core histones undergo posttranslational modifications such as acetylation and methylation.^1-2 Addition of acetyl group or 1 to 3 methyl groups occur at position specific lysines.^3-4 These modifications, as well as phosphorylation of serine residues and others, serve to differentially regulate chromatin activity.⁵

Request AnaSpec’s forthcoming Combinatorial Chemistry catalog

Acetylated Lysines

Product	Size	Catalog #
Fmoc-Lys(Ac)-OH N-α-Fmoc-N-ε-acetyl-L-lysine, CAS# 159766-56-0	1 g	22502
	5 g	23356
Boc-Lys(Ac)-OH N-α-t-Boc-N-ε-acetyl-L-lysine, CAS# 6404-26-8	1 g	23084
	5 g	23085

Methylated Lysines

Product	Size	Catalog #
Fmoc-Lys(Me, Boc)-OH NEW N-α-Fmoc-N-ε,ε-t-Boc-methyl-L-lysine	0.25 g	60327-025
	1 g	60327-1
	5 g	60327-5
Fmoc-Lys(Me)2-OH • HCl Fmoc-N^ε,^ε-dimethyl-L-lysine hydrochloride salt CAS# 252049-10-8	250 mg	28211
	1 g	28212
Boc-Lys(Me)2-OH Boc-N^ε,^ε-dimethyl-L-lysine	250 mg	60025-025
Boc-Lys(Me)2-OH Boc-N^ε,^ε-dimethyl-L-lysine	1 g	60025-1
Fmoc-Lys(Me)3-OH chloride NEW N-α-Fmoc-N-ε;ε;ε-trimethyl-L-lysine chloride	1 g	60260-1

Phosphorylated

Product	Size	Catalog #
Fmoc-Ser[PO(OBzl)-OH]-OH N-α-Fmoc-O-benzyl-L-phosphoserine, CAS# 158171-14-3	1 g	20419
	5 g	20420
Fmoc-D-Ser[PO(OBzl)-OH]-OH NEW N-α-Fmoc-O-benzyl-D-phosphoserine	1 g	60083-1
	5 g	60083-5
Fmoc-Thr[PO(OBzl)-OH]-OH N-α-Fmoc-O-benzyl-L-phosphothreonine, CAS# 175291-56-2	1 g	20835
	5 g	20836
Fmoc-D-Thr[PO(OBzl)-OH]-OH N-α-Fmoc-O-benzyl-D-phosphothreonine	1 g	60557-1
	5 g	60557-5
Fmoc-Tyr[PO(OBzl)OH]-OH N-α-Fmoc-O-benzyl-L-phosphotyrosine, CAS# 191348-16-0	1 g	27259
	5 g	27260
Fmoc-D-Tyr[PO(OBzl)OH]-OH N-α-Fmoc-O-benzyl-D-phosphotyrosine	1 g	61428-1
	5 g	61428-5

Related Products

Product	Size	Catalog #
Fmoc-Arg(Me)2-OH (symmetrical) Fmoc-N^ω,^ω-dimethyl-L-arginine (symmetrical)	250 mg	26217-F025
	1 g	26217-F1
Fmoc-Arg(Me)2-OH (asymmetrical) Fmoc-N^ω,^ω-dimethyl-L-arginine (asymmetrical) CAS# 268564-10-9	250 mg	26218-F025
	1 g	26218-F1
Fmoc-Lys(Biotin)-Amide resin, im N-α-Fmoc-N-ε-(d-Biotin)-L-lysine-Amide resin, im	0.5 g	23848
	1 g	23849
Fmoc-Lys(Biotin)-Wang resin, im N-α-Fmoc-N-ε-(d-Biotin)-L-lysine-Wang resin	0.5 g	21767
	1 g	21769
Fmoc-D-Lys(Biotin)-Wang resin, im N-α-Fmoc-N-ε-(d-Biotin)-D-lysine-Wang resin	0.5 g	61829-05
	1 g	61829-1
Fmoc-Lys(Biotin-LC)-OH N-α-Fmoc-N-ε-(d-Biotin-6-amidocaproate)-L-lysine	0.5 g	22505
	1 g	25096
Fmoc-Lys(Biotin-LC)-Amide resin, im N-α-Fmoc-N-ε-(d-Biotin-6-amidocaproate)-L-lysine-Amide resin, im	0.5 g	29431
	1 g	29432
Fmoc-Lys(Biotin-LC)-Wang resin, im N-α-Fmoc-N-ε-(d-Biotin-6-amidocaproate)-L-lysine-Wang resin	0.5 g	21751
	1 g	21741

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References:

Lachner, M. et al. J. Cell Sci. 116, 2117 (2003).
Talasz, H. et al. J. Biol. Chem. 280, 38814 (2005).
Schotta, G. et al. Genes Dev. 18, 1251 (2004).
Paik, Wk. and S. Kim, Science 174, 114 (1971).
Strahl, BD and CD. Allis, Nature 403, 44 (2000).