AnaSpec’s collection of antibodies continues to expand rapidly. We are pleased to present our newest collection of Anti-LC antibodies that can be used as autophagosome markers.

The mammalian microtubule-associated protein 1 light chain 3 (LC3) is a homolog of the yeast Atg8, a protein that plays a major role in autophagy. LC3 is a fibronectin mRNA-binding protein linked to mRNA translation. MAP1-LC3A, -B, & -C are the three human isoforms of MAP1-LC3 which have been cloned and characterized. These differ in their post-translation modification. MAP-LC3 proteins are related to cell growth, differentiation and migration in development and in diseases. AnaSpec’s anti-LC antibodies were referenced in an article by W. Jackson, et al.³ We are pleased to announce the availability of anti-LC3B, as well as anti-LC3A (which does not cross-react with LC3B) and anti-LC3 A/B (which recognizes both A and B isoforms).

REFERENCES

1. He, H. et al. J. Biol. Chem. 11, 11 (2003).
2. Zhou, B. et al. J. Clin. Invest. 100, 3070 (1997).
3. Jackson, W. et al. Plos Biol. 3, e156 (2005).