AnaSpec is pleased to announce the release of 21 new anti-Tau antibodies.
Complementing one of the world’s most comprehensive collections of b-amyloid
peptides, this new selection of anti-Tau antibodies demonstrates AnaSpec’s
commitment to delivering integrated solutions for Alzheimer research.
Combining expertise in phosphopeptide synthesis with excellent affinity purification
of phosphoantibodies, AnaSpec is able to offer extremely phosphospecific antibodies
which do not cross-react with each other (as shown on the dot blots).
Now through to Feb. 29, 2008, buy 5 or more of the 25 ug size Anti-Tau antibodies
and get a 20% discount (US & Canada only). Discount code – AB208
Tau is a collection of microtubule-associated proteins that is involved in
microtubule assembly and stabilization (1). In adult human brain, 6 isoforms,
ranging between 352 and 441 amino acids in length, are produced as a result
of alternative RNA splicing (2, 3). The expression of Tau isoforms is developmentally
regulated, as only the smallest Tau polypeptide is expressed in the fetal
brain. Hyperphosphorylated Tau is the major component of the paired helical
filament of Alzheimer’s disease. Anti- phospho-Tau antibodies are used
to identify specific amino acids that are phosphorylated in Tau from normal
brains and Alzheimer’s disease brains. The Tau proteins, especially
in developing brains and in Alzheimer brains, are phosphorylated in vivo at
many different sites such as Thr181, Ser198, Ser199, Ser202, Thr205, Thr212,
Ser214, Thr217, Thr231, Ser235, Ser262, Ser356, Ser396, Ser400, and Ser404
Rabbit anti-Phospho-Tau antibodies were raised against synthetic phosphopeptides
corresponding to the human Tau at the following sites: Thr181, Ser198, Ser199,
Ser202, Ser199/202, Thr205, Thr212, Ser214, Thr217, Thr231, Ser235, Ser262,
Ser356, Ser396, Ser400, and Ser404. These antibodies were evaluated for specificity
with ELISA and/or Western blot. By Western blot, an immunoreactive band around
52 kDa was observed in the mouse whole brain lysate. Species reactivity includes
human, mouse and rat. Some antibodies have also shown reactivity with bovine,
chicken and zebrafish.
here to request AnaSpec’s newest Antibodies Brochure
a or b-Secretase Assay Kits
Dyes for detection of amyloid fibrils
Antibodies Sampler Sets
1. Cleveland, DW. et al. J. Mol. Biol. 116, 207 (1977).
2. Goedert, M. et al. Neuron 3, 519 (1989).
3. Geodert, M. et al. EMBO J. 8,
4. Billingsley, M. et al. Biochem
J. 323, 577 (1997) .
5. Hanger, DP. et al. J. Neurochem.
71, 2465. (1998).