Anti-Tau Antibodies Ė phosphorylated and non-phosphorylated


AnaSpec is pleased to announce the release of 21 new anti-Tau antibodies. Complementing one of the world’s most comprehensive collections of b-amyloid peptides, this new selection of anti-Tau antibodies demonstrates AnaSpec’s commitment to delivering integrated solutions for Alzheimer research.

Combining expertise in phosphopeptide synthesis with excellent affinity purification of phosphoantibodies, AnaSpec is able to offer extremely phosphospecific antibodies which do not cross-react with each other (as shown on the dot blots).

Now through to Feb. 29, 2008, buy 5 or more of the 25 ug size Anti-Tau antibodies and get a 20% discount (US & Canada only). Discount code – AB208

Tau is a collection of microtubule-associated proteins that is involved in microtubule assembly and stabilization (1). In adult human brain, 6 isoforms, ranging between 352 and 441 amino acids in length, are produced as a result of alternative RNA splicing (2, 3). The expression of Tau isoforms is developmentally regulated, as only the smallest Tau polypeptide is expressed in the fetal brain. Hyperphosphorylated Tau is the major component of the paired helical filament of Alzheimer’s disease. Anti- phospho-Tau antibodies are used to identify specific amino acids that are phosphorylated in Tau from normal brains and Alzheimer’s disease brains. The Tau proteins, especially in developing brains and in Alzheimer brains, are phosphorylated in vivo at many different sites such as Thr181, Ser198, Ser199, Ser202, Thr205, Thr212, Ser214, Thr217, Thr231, Ser235, Ser262, Ser356, Ser396, Ser400, and Ser404 (4, 5).

Rabbit anti-Phospho-Tau antibodies were raised against synthetic phosphopeptides corresponding to the human Tau at the following sites: Thr181, Ser198, Ser199, Ser202, Ser199/202, Thr205, Thr212, Ser214, Thr217, Thr231, Ser235, Ser262, Ser356, Ser396, Ser400, and Ser404. These antibodies were evaluated for specificity with ELISA and/or Western blot. By Western blot, an immunoreactive band around 52 kDa was observed in the mouse whole brain lysate. Species reactivity includes human, mouse and rat. Some antibodies have also shown reactivity with bovine, chicken and zebrafish.

Click here to request AnaSpecís newest Antibodies Brochure


Product name

50 ug

25 ug

Anti-Tau (pThr181)

54960

54960-025

Anti-Tau (pSer198)

54962

54962-025

Anti-Tau (pSer199/202)

54963

54963-025

Anti-Tau (pSer202)

28017

28017-025

Anti-Tau (pThr205)

54964

54964-025

Anti-Tau (pThr212)

54966

54966-025

Anti-Tau (pSer214)

54967

54967-025

Anti-Tau (pThr217)

54968

54968-025

Anti-Tau (pSer262)

54973

54973-025

Anti-Tau (pSer356)

54975

54975-025

Anti-Tau (pSer396)

54977

54977-025

Anti-Tau (pSer400)

54978

54978-025

Anti-Tau (pSer404)

28023

28023-025

Anti-Tau (paired181)

54961

54961-025

Anti-Tau (paired198,199,202,205)

54965

54965-025

Anti-Tau (paired202)

28018

28018-025

Anti-Tau (paired212,214,217)

54969

54969-025

Anti-Tau (paired262)

54974

54974-025

Anti-Tau (paired356)

54976

54976-025

Anti-Tau (paired396,400,404)

54979

54979-025

Anti-Tau (paired404)

28024

28024-025

Related Products:

b-Amyloid and Related Peptides
SensoLyteTM a or b-Secretase Assay Kits
Amyloid Antibodies
Fluorescent Dyes for detection of amyloid fibrils
Other Antibodies Sampler Sets

REFERENCES:

1. Cleveland, DW. et al. J. Mol. Biol. 116, 207 (1977).
2. Goedert, M. et al. Neuron 3, 519 (1989).
3. Geodert, M. et al. EMBO J. 8, 393 (1989).
4. Billingsley, M. et al. Biochem J. 323, 577 (1997) .
5. Hanger, DP. et al. J. Neurochem. 71, 2465. (1998).