AnaSpec is pleased to announce the release of 21 new anti-Tau antibodies. Complementing one of the world’s most comprehensive collections of b-amyloid peptides, this new selection of anti-Tau antibodies demonstrates AnaSpec’s commitment to delivering integrated solutions for Alzheimer research.

Combining expertise in phosphopeptide synthesis with excellent affinity purification of phosphoantibodies, AnaSpec is able to offer extremely phosphospecific antibodies which do not cross-react with each other (as shown on the dot blots).

Now through to Feb. 29, 2008, buy 5 or more of the 25 ug size Anti-Tau antibodies and get a 20% discount (US & Canada only). Discount code – AB208

Tau is a collection of microtubule-associated proteins that is involved in microtubule assembly and stabilization (1). In adult human brain, 6 isoforms, ranging between 352 and 441 amino acids in length, are produced as a result of alternative RNA splicing (2, 3). The expression of Tau isoforms is developmentally regulated, as only the smallest Tau polypeptide is expressed in the fetal brain. Hyperphosphorylated Tau is the major component of the paired helical filament of Alzheimer’s disease. Anti- phospho-Tau antibodies are used to identify specific amino acids that are phosphorylated in Tau from normal brains and Alzheimer’s disease brains. The Tau proteins, especially in developing brains and in Alzheimer brains, are phosphorylated in vivo at many different sites such as Thr181, Ser198, Ser199, Ser202, Thr205, Thr212, Ser214, Thr217, Thr231, Ser235, Ser262, Ser356, Ser396, Ser400, and Ser404 (4, 5).

Rabbit anti-Phospho-Tau antibodies were raised against synthetic phosphopeptides corresponding to the human Tau at the following sites: Thr181, Ser198, Ser199, Ser202, Ser199/202, Thr205, Thr212, Ser214, Thr217, Thr231, Ser235, Ser262, Ser356, Ser396, Ser400, and Ser404. These antibodies were evaluated for specificity with ELISA and/or Western blot. By Western blot, an immunoreactive band around 52 kDa was observed in the mouse whole brain lysate. Species reactivity includes human, mouse and rat. Some antibodies have also shown reactivity with bovine, chicken and zebrafish.

Click here to request AnaSpec’s newest Antibodies Brochure

Product name	50 ug	25 ug
Anti-Tau (pThr181)	54960	54960-025
Anti-Tau (pSer198)	54962	54962-025
Anti-Tau (pSer199/202)	54963	54963-025
Anti-Tau (pSer202)	28017	28017-025
Anti-Tau (pThr205)	54964	54964-025
Anti-Tau (pThr212)	54966	54966-025
Anti-Tau (pSer214)	54967	54967-025
Anti-Tau (pThr217)	54968	54968-025
Anti-Tau (pSer262)	54973	54973-025
Anti-Tau (pSer356)	54975	54975-025
Anti-Tau (pSer396)	54977	54977-025
Anti-Tau (pSer400)	54978	54978-025
Anti-Tau (pSer404)	28023	28023-025
Anti-Tau (paired181)	54961	54961-025
Anti-Tau (paired198,199,202,205)	54965	54965-025
Anti-Tau (paired202)	28018	28018-025
Anti-Tau (paired212,214,217)	54969	54969-025
Anti-Tau (paired262)	54974	54974-025
Anti-Tau (paired356)	54976	54976-025
Anti-Tau (paired396,400,404)	54979	54979-025
Anti-Tau (paired404)	28024	28024-025

Related Products:

b-Amyloid and Related Peptides
SensoLyte^TM a or b-Secretase Assay Kits
Amyloid Antibodies
Fluorescent Dyes for detection of amyloid fibrils
Other Antibodies Sampler Sets

REFERENCES:

1. Cleveland, DW. et al. J. Mol. Biol. 116, 207 (1977).
2. Goedert, M. et al. Neuron 3, 519 (1989).
3. Geodert, M. et al. EMBO J. 8, 393 (1989).
4. Billingsley, M. et al. Biochem J. 323, 577 (1997) .
5. Hanger, DP. et al. J. Neurochem. 71, 2465. (1998).