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With one of
the world’s largest collections of peptides, AnaSpec continues to expand
its selection every week. This month AnaSpec highlights its selection of
channel blocker peptides.
Peptide toxins are potent and selective compounds that can act on ion channels
in plasma membrane of excitable cells.1 These high specificity
and affinity compounds, often with diverse and selective pharmacologies, are
used as pharmacological probes to study and characterize various receptor
proteins involved in ion-channel function.1 These toxin peptides
generally consist of a relatively small number of structural frameworks that
are particularly suited to addressing the crucial issues of potency and stability.1
Multiple disulfide bonds constitute essential structural elements in many
of these bioactive peptides, which are generated by proteolytic processing
of prefolded protein precursors and then released from the cells in the bioactive
form into the extracellular medium to exert their physiological function.
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Peptides catalog today. Click here.
Ca2+ Channel Blockers
| Peptide
Name |
Source |
Sequence |
Disulfide
Bridge |
Channel
Type/Action of class |
Size
(mg) |
Catalog# |
| ω-Conotoxin GVIA |
Marine
snail,
Conus geographus |
CKS(Hyp)GSSCS(Hyp)
TSYNCCRSCN(Hyp)
YTKRCY-NH2 |
C1-C16, C8-C19, C15-C26 |
N-type. Binds Neuronal
Ca2+ channels. Blocks synapse neurotransmitter release reversibly. |
0.5
1 |
22926
22927 |
| ω-Conotoxin MVIIC |
Cone snail,
Conus magus |
CKGKGAPCRKTMYD
CCSGSCGRRGKC-NH2 |
C1-C16, C8-C20, C15-C26 |
P/Q Type |
0.1
0.5 |
20580
27058 |
| ω-Conotoxin
MVIIA |
Cone snail,
Conus magus |
CKGKGAKCSRLMYD
CCTGSCRSGKC-NH2 |
C1-C16, C8-C20, C15-C25 |
N Type |
0.5
1 |
20579
27057 |
| Imperatoxin A (IpTxa) |
Scorpion, Pandinus imperator |
GDCLPHLKRCKADNDCC
GKKCKRRGTNAEKRCR |
C3-C17,
C10-C21,
C16-C32 |
Ryanodine receptor agonist |
0.1 |
60762 |
| Agelenin |
Spider,
Agelena opulenta |
GGCLPHNRFCNALSGPR
CCSGLKCKELSIWD
SRCL-NH2 |
C3-C19, C10-C24, C18-C34 |
presynaptic Ca2+
channel blocker |
0.1 |
61646 |
K+ Channel
Blockers
| Iberiotoxin (IbTX) |
Scorpion,
Buthus tamulus |
Pyr-FTDVDCSVS
KECWSVCKDLFGVDR
GKCMGKKCRCYQ |
C7-C28, C13-C33, C17-C35 |
BK type 1 ;
Ca2+, K channel inhibitor |
0.1 |
60763 |
| Charybdotoxin |
Scorpion, Leiurus quinquestriatus
hebraeus |
Pyr-FTNVSCTTS
KECWSVCQRLHNTSR
GKCMNKKCRCYS |
C7-C28, C13-C33, C17-C35 |
Ca2+activated
K+channel blocker |
0.1
1 |
28244
22428 |
| [Glu32]-Charybdotoxin |
|
Pyr-FTNVSCTTS
KECWSVCQRLHNTSR
GKCMNKECRCYS |
C7-C28, C13-C33, C17-C35 |
|
0.1
1 |
61200-01
61200-1 |
| Apamin |
Bee |
CNCKAPETALCARRCQQH-NH2 |
C1-C11,
C3-C15 |
Ca2+ dependent
K+ channel blocker, SK blocker |
0.5 |
60772 |
| Mast Cell Degranulating
Peptide, MCD |
Honeybee,
Apis mellifera |
IKCNCKRHVIKPHICRKICGKN-NH2 |
C3-C15,
C5-C19 |
K+ channel blocker |
0.5 |
60765 |
Cl-Channel
Blocker
| Chlorotoxin (Cltx) |
Scorpion,
Leiurus quinquestriatus |
MCMPCFTTDHQMARKCDDCCGGKGA
GKCYGPQCLCR-NH2 |
C2-C19,
C5-C28, C16-C33, C20-C35 |
Cl-
channel blocker |
0.1 |
60770 |
Other Ion Channel Blockers
| Conantokin
G |
Fish
eating snail,
Conus geographus |
GE(Gla)(Gla)LQ(Gla)NQ
(Gla)LIR(Gla)KSN-NH2 |
|
NMDA
receptor glutamate antagonist |
0.25
0.5
1 |
28243
24281
24282 |
| Sarafotoxin
6C |
|
CTCNDMTDEECLNFCHQDVIW |
C1-C15,
C3-C11 |
ET
receptor subtype B agonist |
0.5
1 |
24325
24326 |
| [Lys4]-Sarafotoxin
6c |
|
CTCKDMTDEECLNFCHQDVIW |
C1-C15,
C3-C11 |
ET
receptor subtype B agonist |
0.5
1 |
24327
24328 |
| Beauvericin |
Beauveria
bassiana |
Cyclo( - D - α -
hydroxyisovaleryl
- N - Me - Phe)3 |
|
Cholesterol
acyltransferase inhibitor |
5 |
61175 |
Related
Services:
Custom
Peptide Synthesis
Reference:
1. Lewis, RJ. and ML. Garcia, Nat. Rev. Drug Discov. 2,
790 (2003).
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