Channel Blocker Peptides


With one of the world’s largest collections of peptides, AnaSpec continues to expand its selection every week.  This month AnaSpec highlights its selection of channel blocker peptides.

Peptide toxins are potent and selective compounds that can act on ion channels in plasma membrane of excitable cells.1  These high specificity and affinity compounds, often with diverse and selective pharmacologies, are used as pharmacological probes to study and characterize various receptor proteins involved in ion-channel function.1 These toxin peptides generally consist of a relatively small number of structural frameworks that are particularly suited to addressing the crucial issues of potency and stability.1 Multiple disulfide bonds constitute essential structural elements in many of these bioactive peptides, which are generated by proteolytic processing of prefolded protein precursors and then released from the cells in the bioactive form into the extracellular medium to exert their physiological function.

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Ca2+ Channel Blockers

Peptide Name

Source

Sequence

Disulfide Bridge

Channel Type/Action of class

Size (mg)

Catalog#

ω-Conotoxin GVIA

Marine snail,

Conus geographus

CKS(Hyp)GSSCS(Hyp)
TSYNCCRSCN(Hyp)
YTKRCY-NH2

C1-C16, C8-C19, C15-C26

N-type. Binds Neuronal Ca2+ channels. Blocks synapse neurotransmitter release reversibly.

0.5

1

22926

22927

ω-Conotoxin MVIIC

Cone snail,

Conus magus

CKGKGAPCRKTMYD
CCSGSCGRRGKC-NH2

C1-C16, C8-C20, C15-C26

P/Q Type

0.1

0.5

20580

27058

ω-Conotoxin MVIIA

Cone snail,

Conus magus

CKGKGAKCSRLMYD
CCTGSCRSGKC-NH2

C1-C16, C8-C20, C15-C25

N Type

0.5

1

20579

27057

Imperatoxin A (IpTxa)

Scorpion, Pandinus imperator

GDCLPHLKRCKADNDCC
GKKCKRRGTNAEKRCR

C3-C17,

C10-C21,

C16-C32

Ryanodine receptor agonist

0.1

60762

Agelenin

Spider,

Agelena opulenta

GGCLPHNRFCNALSGPR
CCSGLKCKELSIWD
SRCL-NH2

C3-C19, C10-C24, C18-C34

presynaptic Ca2+ channel blocker

0.1

61646

K+ Channel Blockers

Iberiotoxin (IbTX)

Scorpion,

Buthus tamulus

Pyr-FTDVDCSVS

KECWSVCKDLFGVDR
GKCMGKKCRCYQ

C7-C28, C13-C33, C17-C35

BK type 1 ; Ca2+, K channel inhibitor

0.1

60763

Charybdotoxin

Scorpion, Leiurus quinquestriatus hebraeus

Pyr-FTNVSCTTS

KECWSVCQRLHNTSR
GKCMNKKCRCYS

C7-C28, C13-C33, C17-C35

Ca2+activated K+channel blocker

0.1

1

28244

22428

[Glu32]-Charybdotoxin

 

Pyr-FTNVSCTTS

KECWSVCQRLHNTSR
GKCMNKECRCYS

C7-C28, C13-C33, C17-C35

 

0.1

1

61200-01

61200-1

Apamin

Bee

CNCKAPETALCARRCQQH-NH2

C1-C11,

C3-C15

Ca2+ dependent K+ channel blocker, SK blocker

0.5

60772

Mast Cell Degranulating Peptide, MCD

Honeybee,

Apis mellifera

IKCNCKRHVIKPHICRKICGKN-NH2

C3-C15,

C5-C19

K+ channel blocker

0.5

60765

Cl-Channel Blocker

Chlorotoxin (Cltx)

Scorpion,

Leiurus quinquestriatus

MCMPCFTTDHQMARKCDDCCGGKGA
GKCYGPQCLCR-NH2

C2-C19, C5-C28, C16-C33, C20-C35

Cl- channel blocker

0.1

60770

Other Ion Channel Blockers

Conantokin G

Fish eating snail,

Conus geographus

GE(Gla)(Gla)LQ(Gla)NQ
(Gla)LIR(Gla)KSN-NH2

 

NMDA receptor glutamate antagonist

0.25

0.5

1

28243

24281

24282

Sarafotoxin 6C

 

CTCNDMTDEECLNFCHQDVIW

C1-C15,

C3-C11

ET receptor subtype B agonist

0.5

1

24325

24326

[Lys4]-Sarafotoxin 6c

 

CTCKDMTDEECLNFCHQDVIW

C1-C15, C3-C11

ET receptor subtype B agonist

0.5

1

24327

24328

Beauvericin

Beauveria bassiana

Cyclo( - D - α - hydroxyisovaleryl
- N - Me - Phe)3

 

Cholesterol acyltransferase inhibitor

5

61175

Related Services:

Custom Peptide Synthesis

Reference:

1.  Lewis, RJ. and ML. Garcia, Nat. Rev. Drug Discov. 2, 790 (2003).