is pleased to announce the release of two antibodies for growth secretagogue
receptor (GHSR). One antibody targets the N-terminus and the other an internal
GHSR is a G protein-coupled receptor with seven transmembrane domains
and is primarily expressed in hypothalamus and pituitary glands (1-4). GHSR
gene is located on chromosome 3q26.31 and results in two products: functional
366 amino acids long GSHR1a and 289 amino acids long GSHR1b protein with yet
unknown function1,2. GHSR1a is activated by 28 amino acid peptide
ghrelin that is esterified with octanoic acid on Ser3 and must
be acylated to induce GHSR response2,3. Activated GHSR modulates
phospholipase C signaling route that leads to increase of intracellular calcium
ions that stimulate brain cells to release growth hormone and increase appetite
1-4. Recent studies in transgenic mice indicate that GHSR may be
responsible for obesity and short normal stature1.
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1.Wang H-J et al. J. Clin. Endo. Metab. 89,
2.Baldanzi G et al. J. Cell Bio. 159, 1029
3.Casanueva FF. & C. Dieguez, Growth, Genetics &
Hormones 20, 1 (2004).
4.Abizaid A et al. J. Clin. Invest. 116, 3229 (2006).