Histones Peptides are GO™ – Acetylated & Methylated


The core histones (H2A, H2B, H3 and H4) act as spools around which DNA winds. Covalent modification on the amino terminal of the core histones through de/acetylation, de/methylation and de/phosphorylation affect chromatin structure and exquisitely regulate gene expression.1-3 Histone hyperacetylation is correlated with increased transcription, whereas hypoacetylation correlates with transcriptional repression.2

AnaSpec, the world’s largest provider of on-demand GO peptides is pleased to announce the rapid expansion of our histone peptide selection. Histone GOTM Peptides include sequences that are acetylated and di- or tri-methylated. For sequences that are not found on this list, please request a custom quotation here.

Histone H1 Peptides

Product

Size

Catalog #

Histone H1’ (22-42), human, mouse NEW

STDHPKYSDMIVAAIQAEKNR

1 mg

63674

PKTPKKAKKL Histone H1

1 mg

60026-1

Histone H1-derived Peptide NEW

GGGPATPKKAKKL

1 mg

61761

Histone H1-derived Peptide, phosphorylated NEW

GGGPA-pT-PKKAKKL

1 mg

61741

Histone H1-derived Peptide, FAM-labeled NEW

5-FAM-GGGPATPKKAKKL

1 mg

61762

Histone H1-derived Peptide, TAMRA-labeled NEW

5-TAMRA-GGGPATPKKAKKL

1 mg

61763

H2A Peptides

Product

Size

Catalog #

Histone H2A (1-20) NEW

SGRGKQGGKARAKAKTRSSR

1 mg

63676

[Lys(Biotin)9]-Histone H2A (1-12)-Cys NEW

SGRGKQGG-K(Biotin)-ARAC

1 mg

63675

Histone H3 Peptides

Product

Size

Catalog #

Histone H3 (1-20), N-Terminal NEW

ARTKQTARKSTGGKAPRKQL

1 mg

62753

Histone H3 (1-21), N-Terminal

ARTKQTARKSTGGKAPRKQLA

1 mg

61701

Histone H3 (1-21)-Cys NEW

ARTKQTARKSTGGKAPRKQLA-C

1 mg

63789

Histone H3 (1-21)-GGK, Biotin-labeled

ARTKQTARKSTGGKAPRKQLA-GG-K(BIOTIN)-NH2

1 mg

61702

Histone H3 (1-21)-GGK, FAM-labeled NEW

ARTKQTARKSTGGKAPRKQLA-GG-K(FAM)-NH2

1 mg

63824

Histone H3 (1-25), amide

ARTKQTARKSTGGKAPRKQLATKAA-NH2

1 mg

61703

Histone H3 (15–39)

APRKQLATKAARKSAPATGGVKKPH

1 mg

61705

Histone H3 (116–136), C116–136

KRVTIMPKDIQLARRIRGERA

1 mg

61704

[Lys(Ac)14]-Histone H3 (1-19), H3K14(Ac) NEW

ARTKQTARKSTGG-K(Ac)-APRKQL

1 mg

63682

[Lys(Ac)9]-Histone H3 (1-20), H3K9(Ac) NEW

ARTKQTAR-K(Ac)-STGGKAPRKQL

1 mg

63680

[Lys(Ac)14]-Histone H3 (9-19), H3K14(Ac) NEW

KSTGG-K(Ac)-APRKQ

1 mg

63681

[Lys(Me2)4]-Histone H3 (1-21), H3K4(Me2) NEW

ART-K(Me2)-QTARKSTGGKAPRKQLA

1 mg

63677

[Lys(Me2)4]-Histone H3 (1 - 21), H3K4(Me2), FAM labeled NEW

ART-K(Me2)-QTARKSTGGKAPRKQLAGG-K(FAM)-NH2

1 mg

63825

[Lys(Me3)9]-Histone H3 (1-24), H3K9(Me3) NEW

ARTKQTAR-K(Me3)-STGGKAPRKQLATKA

0.5 mg

63679

[Lys(Me2)9]-Histone H3 (1-24), H3K9(Me2), Biotin-labeled NEW

ARTKQTAR-K(Me2)-STGGKAPRKQLA-K(Biotin)

1 mg

63678

Histone H4 Peptides

Product

Size

Catalog #

Histone H4 (1-7), N-Terminal NEW

SGRGKGG

1 mg

62754

Histone H4 (1-20), PRMT7 Substrate, M1 NEW

SGRGKGGKGLGKGGAKRHRK-NH2

1 mg

62498

Histone H4 (1-21), p300/CBP Substrate NEW

SGRGKGGKGLGKGGAKRHRKV

1 mg

62499

Histone H4 (1-21)-Lys(Biotin) NEW

Ac-SGRGKGGKGLGKGGAKRHRKVGG-K(Biotin)

1 mg

62555

[Lys(Ac)5]-Histone H4 (1-20), H4K5(Ac) NEW

SGRG-K(Ac)-GGKGLGKGGAKRHRK

1 mg

63683

[Lys(Ac)8]-Histone H4 (1-20), H4K8(Ac) NEW

SGRGKGG-K(Ac)-GLGKGGAKRHRK

1 mg

63684

[Lys(Ac)12]-Histone H4 (1-20), H4K12(Ac) NEW

SGRGKGGKGLG-K(Ac)-GGAKRHRK

1 mg

63685

[Lys(Ac)16]-Histone H4 (1-20), H4K16(Ac) NEW

SGRGKGGKGLGKGGA-K(Ac)-RHRK

1 mg

63687

Histone H4 –12, p300/CBP Substrate NEW

RGKGGKGLGKGA

1 mg

62500

[Lys(Ac)16]-Histone H4 (14-21), Mca-labeled, H4K16(Ac) (14-21), pepH4 - AcK16 NEW

Mca-GA-K(Ac)-RHRKV-NH2

1 mg

63686

Related Products

AnaSpec is the sole provider of the industry’s long wavelength HDAC assay kit, the SensoLyte 520 HDAC Activity Assay Kit. We also provide unusual amino acid building blocks such as Lys(Ac), Lys(Me1-3), Arg(Me2) , pSer and pThr for histone peptide synthesis.

References:

1. Jenuwein, T. and CD. Allis Science 293, 1074 (2001).
2. Sterner, DE. et al. Microbiol. Mol. Biol. Rev. 64, 435 (2000).
3. Lachner, M. et al. J. Cell Sci. 116, 2117 (2003).

Updated June 2, 2009