Matrix metalloproteinases (MMPs) belong to a family
of secreted or membrane-associated zinc endopeptidases involved in both normal
and diseased tissue remodeling. They are capable of degrading all kinds of
extracellular matrix (ECM) proteins, but also can process a number of bioactive
molecules. MMPs are key players in normal and pathological processes, including
embryogenesis, wound healing, inflammation, arthritis, and cancer.
MMPs share common structural and functional elements
and are products of different genes. The three common domains include the pro-peptide, the
catalytic domain and the haemopexin-like C-terminal domain linked to the catalytic
domain by a flexible hinge region. MMPs are initially synthesized as inactive
(latent) zymogens with a pro-peptide domain that must be removed before the
enzyme is active.
AnaSpec is pleased to complement its MMP product line with
a suite of SensoLyteTM MMP ELISA Kits. These kits are ideal for
quantitative detection of MMP proteins (latent and active forms) in serum,
plasma, cell culture supernates and urine. The SensoLyteTM ELISA
Kits use a convenient, 96-well plate based format with colorimetric read-out.
AnaSpec’s widely used fluorescent SensoLyteTM MMP
Activity Assays measure active MMPs in a convenient, 96-well plate-based method
with highly sensitive fluorimetric read-out. A colorimetric read-out MMP Activity
Assay kit is also available.
Request
AnaSpec’s new FRET Probes Brochure
today
Related Products
SensoLyte 520
MMP Activity Assay Kits *Fluorescent*
SensoLytePlus
520 MMP Activity Assay Kits *Fluorescent*
Breaking
News: SensoLyte Plus™ 520 MMP - 9 Assay
Kit (cat# 72017) has been
reported to work in
rat primary microglial cell extract
[Woo,
M-S. et al. J. Neurochem. 106, 770 (2008)].
SensoLyte 490
MMP Activity Assay Kits *Fluorescent*
MMP Recombinant
Proteins
MMP
Antibodies
IHC images
MMP Substrates
& Related Peptides
