New Anti-Tau Antibodies - Phosphospecific


AnaSpec is excited to announce the release of 4 more new phosphospecific anti-Tau antibodies. This represents the industry's largest collection of anti-Tau antibodies - 17 phosphospecific and 9 non-phosphospecific antibodies.
AnaSpec's expertise in phosphopeptide synthesis combined with excellent affinity purification has resulted in the production of an anti-Tau to phosphoserine at position 235 (cat# 55315) clearly delineated from one at phosphoserine position 238 (cat# 55323). Our phosphospecific antibodies do not cross-react with each other (see Figure 1).

To view NEW Tau Antibodies and Proteins and Peptides, please click here.


Figure 1. Dot blot of Tau antibodies.

Tau is a collection of microtubule-associated proteins that is involved in microtubule assembly and stabilization (1). In adult human brain, 6 isoforms, ranging between 352 and 441 amino acids in length, are produced as a result of alternative RNA splicing (2, 3). The expression of Tau isoforms is developmentally regulated, as only the smallest Tau polypeptide is expressed in the fetal brain. Hyperphosphorylated Tau is the major component of the paired helical filament of Alzheimer's disease. Anti-phospho-Tau antibodies are used to identify specific amino acids that are phosphorylated in Tau from normal brains and Alzheimer's disease brains. The Tau proteins, especially in developing brains and in Alzheimer brains, are phosphorylated in vivo at many different sites such as Thr181, Ser198, Ser199, Ser202, Thr205, Thr212, Ser214, Thr217, Thr231, Ser235, Ser262, Ser356, Ser396, Ser400, Ser404 and Ser413 (4, 5).
Rabbit anti-Phospho-Tau antibodies were raised against synthetic phosphopeptides. These antibodies were evaluated for specificity with ELISA and/or Western blot. By Western blot, an immunoreactive band around 52 kDa was observed in the mouse whole brain lysate. Species reactivity includes human, mouse and rat. Some antibodies have also shown reactivity with bovine, chicken and zebrafish.
Complementing one of the world's most comprehensive collections of b-amyloid peptides, the availability of these anti-Tau antibodies demonstrates AnaSpec's commitment to delivering integrated solutions for Alzheimer research.
Click here for more information.

NEW Tau Antibodies

Product 50 ug 25 ug

Anti-Tau (pThr231)

55313

55313-025

Anti-Tau (pSer235)

55315

55315-025

Anti-Tau (pSer238)

55323

55323-025

Anti-Tau (pSer413)

55325

55325-025


Previously Released Tau Antibodies

Product

50 ug

25 ug

Anti-Tau

53884

NA

Anti-Tau (pThr181)

54960

54960-025

Anti-Tau (paired181)

54961

54961-025

Anti-Tau (pSer198)

54962

54962-025

Anti-Tau (pSer199, 202)

54963

54963-025

Anti-Tau (pSer202)

28017

28017-025

Anti-Tau (paired202)

28018

28018-025

Anti-Tau (pThr205)

54964

54964-025

Anti-Tau (paired198, 199, 202, 205)

54965

54965-025

Anti-Tau (pThr212)

54966

54966-025

Anti-Tau (pSer214)

54967

54967-025

Anti-Tau (pThr217)

54968

54968-025

Anti-Tau (paired212, 214, 217)

54969

54969-025

Anti-Tau (pSer262)

54973

54973-025

Anti-Tau (paired262)

54974

54974-025

Anti-Tau (pSer356)

54975

54975-025

Anti-Tau (paired356)

54976

54976-025

Anti-Tau (pSer396)

54977

54977-025

Anti-Tau (pSer400)

54978

54978-025

Anti-Tau (pSer404)

28023

28023-025

Anti-Tau (paired404)

28024

28024-025

Anti-Tau (paired396, 400, 404)

54979

54979-025

Related Products

World's largest selection of b-amyloid and related peptides.
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SensoLyte™b-Secretase Assay Kit

REFERENCES:

1. Cleveland, DW. et al. J. Mol. Biol. 116, 207 (1977).
2. Goedert, M. et al. Neuron 3, 519 (1989).
3. Geodert, M. et al. EMBO J. 8, 393 (1989).
4. Billingsley, M. et al. Biochem J. 323, 577 (1997) .
5. Hanger, DP. et al. J. Neurochem. 71, 2465. (1998).