LL-37 peptides are AnaSpec’s latest addition to our expansive collection
of research-ready, on-demand GO™ Peptides. The LL-37 GO™ collection
includes LL-37 fragments consisting of 8-37 and 18-37; FAM, biotin-LC-labeled
LL-37 (LC is a 6-carbon linker); and Cys-LC-LL-37 - useful in applications such
as conjugation to resin. Sepharose linked LL-37 is available as a custom order.
New antimicrobial peptides (AMP) include Dermcidin, DCD-1L and mCRAMP, biotin-LC
labeled.
Cathelicidins are cationic peptides that have broad-range antimicrobial activity.1
These peptides belong to the family of anti-microbial peptides which form part
of the host’s important innate immunity mechanism.2 In humans, cathelicidins
and defensins are expressed in immune cells and at epithelial surfaces.3-5 hCAP18,
human cationic antimicrobial protein, with a MW of 18 kD, is the only cathelicidin
gene found in humans.2 The N-terminus of this protein consists of a cathelin-like
region (highly conserved among species) and a C-terminal termed LL-37.6-7 An amphipathic
alpha-helical peptide, LL-37 plays an important role in the first line of defense
against local infection and systemic invasion of pathogens at sites of inflammation
and wounds. Cytotoxic to both bacterial and normal eukaryotic cells, LL-37 is
significantly resistant to proteolytic degradation in solution.8-9 In addition
to having antimicrobial activity, LL-37 has been shown to play a role in chemoattraction,
dendritic cell differentiation, mast cell degranulation, cytokine secretion, angiogenesis
stimulation, and wound healing.10 In other species, the C-terminal antimicrobial
region varies in sizes, sequences and structures. 10
Click here
for more information.
| Product |
Size |
Catalog # |
| LL - 37, Antimicrobial
Peptide, human
LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES |
1 mg |
61302 |
| LL-37, acetylated
& amidated NEW
Ac-LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES-NH2 |
1 mg |
63710 |
| LL-37
fragment (8-37), LL-8-37 NEW
KSKEKIGKEFKRIVQRIKDFLRNLVPRTES |
1 mg |
63711 |
| LL-37
fragment (18-37), LL-18-37 NEW
KRIVQRIKDFLRNLVPRTES |
1 mg |
63712 |
| 5 - FAM - LC -
LL - 37 NEW
5-FAM-LC-LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES |
0.1 mg |
63694 |
| Biotin - LC -
LL - 37 NEW
Biotin-LC-LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES |
0.5 mg |
63693 |
| Cys - LC - LL
- 37 NEW
C-LC-LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES |
1 mg |
63692 |
| LL - 37, reverse
sequence
SETRPVLNRLFDKIRQVIRKFEKGIKEKSKRFFDGLL |
0.5 mg |
62208 |
| LL-37,
scrambled NEW
GLKLRFEFSKIKGEFLKTPEVRFRDIKLKDNRISVQR |
1 mg |
63708 |
| LL - 37 pentamide
LLGNFFRKSKQKIGKQFKRIVQRIKNFFRNLVPRTQS; more potent than LL-37 |
1 mg |
61309 |
| Dermcidin,
DCD-1L NEW
SSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSVL |
0.5 mg |
63713 |
| RL-37
RLGNFFRKVKEKIGGGLKKVGQKIKDFLGNLVPRTAS; Rhesus monkey |
0.5 mg |
61313 |
| mCRAMP, mouse
GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ; mouse cathelicidin-related
antimicrobial peptide |
1 mg |
61305 |
| mCRAMP, biotin-LC labeled
NEW
Biotin-LC-GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ |
0.5 mg
1 mg |
63709-05
63709-1 |
| rCRAMP
GLVRKGGEKFGEKLRKIGQKIKEFFQKLALEIEQ; rat cathelicidin-related
antimicrobial peptide |
1 mg |
61306 |
|
To view our complete list of anti-microbial peptides (AMPs), please click here.
Related Products:
Peptides:
· Defensins
· Histatins
· Cecropins
· Magainins
· Ovispirins
· Cathepsin
Substrates
Assay Kits:
· SensoLyte Cathepsin
D Assay Kits
· SensoLyte Cathepsin S Assay Kits
· DHL Cell Cytotoxicity
Assay Kits
Request AnaSpec’s soon to
be released GOTM Peptides listing
References:
1. Zanetti, M. et al. J.
Biol. Chem. 268, 522 (1993).
2. Lehrer, R. and T. Ganz. Curr. Opin. Immunol. 11, 23
(1999).
3. Ganz, T. Nat. Rev. Immunol. 3, 710 (2003).
4. Zanetti, M. J. Leukoc. Biol. 75, 39 (2004).
5. Chromek, M. et al. Nature Medicine 12, 636
(2006).
6. Zanetti, M. et al. FEBS Lett. 374, 1 (1995).
7. Sorensen, OE. et al. Blood 97,
3951 (2001).
8. Neville, F. et al. Biophys. J. 90, 1275 (2006)
9. Oren, Z., et al. Biochem. J. 341,
501(1999).
10. Gordon, YJ. et al. Curr. Eye Res. 30, 385 (2005).
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