AnaSpec is pleased to announce the release of 2 new additions to our Anti-MOG ELISA assay kits – the SensoLyte™ Anti-Mouse MOG (1-125) and SensoLyte™ Anti-Rat MOG (1-125) IgG ELISA Assay Kits. These kits are useful for determining the amount of anti-mouse MOG (1-125) and anti-rat MOG (1-125) antibodies, respectively.

MOG (1-125) is found in the extracellular domain of Myelin Oligodendrocyte Glycoprotein (MOG). MOG is a member of the immunoglobulin superfamily and is expressed exclusively in the central nervous system (CNS). Although MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins, it is demonstrated that MOG protein is a crucial autoantigen for multiple sclerosis in humans and experimental autoimmune encephalomyelitis (EAE) in rodents and monkeys.^1-6

The SensoLyte™ Anti-Mouse MOG (1-125) and SensoLyte™ Anti-Rat MOG (1-125) IgG ELISA Assay Kits offer several advantages:

1. The former is mouse-specific and the latter, rat-specific
2. The strips come with pre-coated MOG (1-125) protein, capturing more antibodies that target different epitopes over a range of the MOG (1-125) extracellular domain.
3. Ideal for detecting both B cell and T cell MOG-epitope specific antibodies as well as epitope spreading.
4. Can be used to determine anti-MOG (1-125) amount in serum or cerebrospinal fluid. Absorbance is read at 450 nm.

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Related Products:

SensoLyte™ anti-MOG (35-55) ELISA assay kits

MOG Proteins

MOG & MBP Peptides

PLP Peptides

OVA Peptides

References:

1. Linares, D. et.al. Protein Exp. Purif. 34, 249 (2004).
2. Bettadapura, J. et.al. J. Neurochem. 70, 1593 (1998).
3. Oliver, AR. et al J. Immunol. 171, 462 (2003).
4. Von Budingen, H. et.al. J. Clin. Immunol. 21, 155 (2001).
5. Lyons, J. et.al. Eur. J. Immunol. 29, 3432 (1999).
6. Von Budingen, H. et.al. Eur. J. Immunol. 34, 2072 (2004).