AnaSpec’s
GO™ Peptides line is pleased to
introduce a broad selection of Exendin peptides. Along with a host of popular
Exendin peptides, AnaSpec’s GO™ Peptides line includes Fluorescein-Trp25-Exendin-4 (FLEX) and [Cys(HiLyteFluor™ 647
C2 maleimide)]-Exendin-4 - two exendin peptides that are not immediately
available anywhere else.
Fluorescein-Trp25-Exendin-4 (FLEX) is Exendin-4 with a fluorescein covalently
attached to Trp at position 25. Useful for binding and characterization studies of the human
GLP-1 receptor, FLEX is equipotent to GLP-1
(7-36)-amide and Exendin-4 as an inhibitor of [125I]-GLP-1 binding
to the human GLP-1 receptor stably expressed in CHO cells.1 [Cys(HiLyte
Fluor™ 647 C2 maleimide)]-Exendin -4 is Exendin-4 with an additional Cys added to the N-terminus.
AnaSpec’s patented HiLyte Fluor™ 647 (Ex/Em=650 nm/675 nm) is attached to the
Cys thiol moiety. Please inquire service@anaspec.com if you are interested
in Fluorescein-Trp25 Glucagon.
Exendin-3 and Exendin-4 are 39-amino
acid peptides from exocrine glands that share about 50% sequence identity to
Glucagon-Like-Peptide-1
(GLP-1) and are potent GLP-1R agonists. 2,3 Exendin-3
stimulates increases in cellular cAMP and amylase release from dispersed guinea
pig pancreatic acini.4 Exendin-4 was originally
isolated from the saliva of the lizard Heloderma suspectum. It is an
insulinotropic agent which improves glucose tolerance
in humans and animals with diabetes. It increases insulin sensitivity via a
PI-3-kinase-dependent mechanism. In the human fetal pancreas, the proliferation
and differentiation of endocrine precursor cells into insulin-producing ß-cells
can be positively regulated by Exendin-4.5 Exendin-4
is an agonist and Exendin (9-39)
is an antagonist of the action of GLP-I (7-36)
amide on arterial blood pressure and heart rate.6
GO™ Peptides represent one of the world’s largest selections of premium quality,
ready-to-go peptides. Drawing from a well-stocked inventory, GO™ Peptides
maintain premium quality without the premium prices and long wait associated
with custom peptides.
Click here to request more
information.
| Product |
Size |
Catalog # |
| Exendin 3
HSDGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
0.5 mg
1 mg |
24461
24462 |
| Exendin 4
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS- NH2 |
0.5 mg
1 mg |
24463
24464 |
| Biotin-Exendin 4
Biotin-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS- NH2 |
0.5 mg
1 mg |
60279-05
60279-1 |
| Exendin 4, FAM-labeled
FAM-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS- NH2 |
0.5 mg
1 mg |
60280-05
60280-1 |
| Fluorescein-Trp25--Exendin-4 (FLEX) NEW
HGEGTFTSDLSKQMEEEAVRLFIE-(Trp-S-FAM)-LKNGGPSSGAPPPS-NH2 |
0.5 mg |
63899 |
| [Des - His1, Glu8] -
Exendin - 4 NEW
GEGTPTSELSKQMEEEAVRLPIEWLKNGGPSSGAPPPS-NH2 |
1 mg |
63900 |
| Exendin 4 (3-39)
EGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
0.5 mg
1 mg |
24465
24466 |
| Exendin (4-39) NEW
GTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
1 mg |
63897 |
| Exendin (5-39) NEW
TFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
1 mg |
63898 |
| Exendin (7-39) NEW
TSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
1 mg |
63902 |
| Exendin (9-39)
DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
0.5 mg
1 mg |
24467
24468 |
| Exendin (10-39) NEW
LSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
1 mg |
63903 |
| [Cys(HiLyteFluor™ 647 C2 maleimide)]-Exendin-4
NEW
C(HiLyte Fluor™ 647 C2 maleimide)-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
50 ug |
63714 |
| Trp Cage
NLYIQWLKDGGPSSGRPPPS |
1 mg |
62072 |
| Glicentin - Related Peptide (21 - 50), human NEW
RSLQDTEEKSRSFSASQADPLSDPDQMNED-NH2 |
1 mg |
63901 |
Related Products:
Agouti Related
Peptides
Amylin Peptides
Cholecystokinin-Pancreozymin
Peptides
Helodermin
Ghrelins and
Obestatins
Glucagon-Like
Peptides (GLP)
Growth Hormone
Releasing Factors
Neuropeptide
Y and Analogs
Oxyntomodulin Peptides
PACAP & PACAP-Related Peptides
(PRP)
Pancreatic Polypeptides
Secretins
Vasoactive Intestinal
Peptides (VIPs)
Anti-SOCS-3 Antibodies
Anti-Ghrelin
Anti-GHSR Antibodies
Anti-Glucagon
Bulk pricing or modifications of the above products are available. Contact
us at service@anaspec.com
References:
1. Chicchi GG. et al. Peptides 18,
319 (1997).
2. Goke, R. et al. J. Biol. Chem.
268, 19650 (1993).
3. Thorens, B. et al. Diabetes 42,
1678 (1993).
4. Eng, J. J. Biol. Chem. 265,
20259 (1990).
5. Movassat, J. et al. J. Clin. Endo.
Metab. 87, 4775 (2002).
6. Barragan, JM. Regul. Peptides
67, 63 (1994).
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