AnaSpec is pleased to announce the release of the newest addition to the Anti-MOG ELISA assay kit series – the SensoLyteÒ Anti-Human MOG (1-125) IgG Quantitation ELISA Kit. This kit, along with previously featured SensoLyteÒ Anti-Mouse MOG (1-125) and SensoLyteÒ Anti-Rat MOG (1-125) IgG ELISA assay kits are useful for determining the amount of anti-human MOG (1-125), anti-mouse MOG (1-125) and anti-rat MOG (1-125) antibodies, respectively. These kits, as well as the recombinant MOG (1-125) proteins are examples of innovative products from AnaSpec.

MOG (1-125) is found in the extracellular domain of Myelin Oligodendrocyte Glycoprotein (MOG). MOG is a member of the immunoglobulin superfamily and is expressed exclusively in the central nervous system (CNS). Although MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins, it is demonstrated that MOG protein is a crucial autoantigen for multiple sclerosis in humans and experimental autoimmune encephalomyelitis (EAE) in rodents and monkeys.^1-6

	SensoLyteÒ Anti-Human MOG (1-125) Assay	SensoLyteÒ Anti-Mouse MOG (1-125) Assay	SensoLyteÒ Anti-Rat MOG (1-125) Assay
Specificity	Human	Mouse	Rat
Format	Human rMOG (1-125) precoated 12-strip plate	Mouse rMOG (1-125) precoated 12-strip plate	Rat rMOG (1-125) precoated 12-strip plate
Standard(s) Included	Mouse & Rat anti-human MOG (1-125) IgG standards	Anti-mouse MOG (1-125) IgG standard	Anti-rat MOG (1-125) IgG standard
Sensitivity	Detects as low as 1 ng anti-human MOG (1-125)	Detects as low as 1 ng anti-mouse MOG (1-125)	Detects as low as 1 ng anti-rat MOG (1-125)
Assay Time	2-3 hours assay time at room temperature
Sample Concentration	0.5-1 µl of serum or cerebrospinal fluid
Read-out	Colorimetric read-out at 450 nm absorbance
Broad Dynamic Range	8-500 ng antibody/ml serum (depending on colorimetric developing time)

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Anti-MOG (1-125) ELISA Assay Kits	Catalog #
SensoLyte® Anti - Human MOG (1 - 125) IgG Quantitative ELISA Kit NEW	55153
SensoLyte® Anti - Mouse MOG (1 - 125) IgG Quantitative ELISA Kit	55156
SensoLyte® Anti - Rat MOG (1 - 125) IgG Quantitative ELISA Kit	55157

Recombinant MOG (1-125) Proteins	Size	Catalog #
Recombinant human MOG (1 - 125) NEW	100 µg 500 µg 1000 µg	55158-100 55158-500 55158-1000
Recombinant mouse MOG (1 - 125) NEW	100 µg 500 µg 1000 µg	55150-100 55150-500 55150-1000
Recombinant rat MOG (1 - 125) NEW	100 µg 500 µg 1000 µg	55152-100 55152-500 55152-1000

Related Products:

SensoLyteÒ anti-MOG (35-55) ELISA assay kits
MOG Proteins
MOG & MBP Peptides
PLP Peptides
OVA Peptides

References:

1. Linares, D. et.al. Protein Exp. Purif. 34, 249 (2004).
2. Bettadapura, J. et.al. J. Neurochem. 70, 1593 (1998).
3. Oliver, AR. et al J. Immunol. 171, 462 (2003).
4. Von Budingen, H. et.al. J. Clin. Immunol. 21, 155 (2001).
5. Lyons, J. et.al. Eur. J. Immunol. 29, 3432 (1999).
6. Von Budingen, H. et.al. Eur. J. Immunol. 34, 2072 (2004).