Proteolytic
processing of proteins in the cytoplasm generates peptide epitopes that are
generally 8-10 amino acids in length. The binding of these peptides to the surface
major histocompatibility complex (MHC) class I molecules and subsequent presentation
to T-cells elicits an immune response.1 A
model antigen extensively studied is Ovalbumin (OVA). OVA is processed to the
presenting octapeptide (257-264), SIINFEKL, through proteasomal and non-proteasomal
activities.2 As with peptides naturally presented by H-2Kb,
SIINFEKL has on its 5th position an amino acid with an aromatic side
chain (Phe) and on the 8th position, an aliphatic side chain (Leu).3
Variants of this peptide consisting of substituting different amino acids at
strategic positions have yielded valuable information on the interaction of
this peptide and the MHC complex.3
The
use of AnaSpec’s SIINFEKL has been reported in peer-reviewed journals since 1997.
We are pleased that researchers have trusted us to provide this important peptide.
We are also pleased to announce the recent release of variants of this peptide.
| Product |
Sequence |
Size |
Catalog
# |
| OVA (257 - 264) |
SIINFEKL |
1 mg
5 mg |
60193-1
60193-5 |
| OVA (257 - 264), amide
|
SIINFEKL - NH2 |
1 mg
5 mg |
62572-1
62572-5 |
| OVA (257 - 264), scrambled
|
FILKSINE |
1 mg |
64413 |
| OVA (257 - 264) Variant E1
|
Pyr - IINFEKL |
1 mg |
60793 |
| OVA – E1 Peptide, (E257) Variant
|
EIINFEKL |
1 mg |
62194 |
| OVA - A2 Peptide, OVA (257 - 264) Variant NEW
|
SAINFEKL |
1 mg |
64383 |
| OVA - G4 Peptide, OVA (257 - 264) Variant NEW
|
SIIGFEKL |
1 mg |
64384 |
| OVA - K4 Peptide, OVA (257 - 264) Variant NEW
|
SIIKFEKL |
1 mg |
64401 |
| OVA - Q4 Peptide, OVA (257 - 264) Variant NEW
|
SIIQFEKL |
1 mg |
64402 |
| OVA - R4 Peptide, OVA (257 - 264) Variant NEW
|
SIIRFEKL |
1 mg |
64382 |
| OVA - T4 Peptide, OVA (257 - 264) Variant NEW
|
SIITFEKL |
1 mg |
64403 |
| OVA - Q4H7 Peptide, OVA (257 - 264) Variant NEW
|
SIIQFEHL |
1 mg |
64405 |
| V-OVA Peptide, OVA (257 - 264) Variant NEW |
RGYNYEKL |
1 mg |
64406 |
| Leu - OVA (257 - 264),
|
LSIINFEKL |
1 mg |
64407 |
| Lys - OVA (257 - 264),
|
KSIINFEKL |
1 mg |
64408 |
| Tyr - OVA (257 - 264), |
YSIINFEKL |
1 mg |
64409 |
| Met - OVA (257 - 264), MSL8 |
MSIINFEKL |
1 mg
5 mg |
62573-1
62573-5 |
| N6-OVA, OVA (251 - 264)
|
GLEQLESIINFEKL |
1 mg |
64410 |
| N9-OVA, OVA (248 - 264)
|
EVSGLEQLESIINFEKL |
1 mg |
64411 |
Related OVA Peptides
| Product |
Sequence |
Size |
Catalog
# |
| OVA - BIP Hybrid Peptide
|
SIINFEKLGSGHWDFAWPW |
1 mg
5 mg |
60194-1
60194-5 |
| OVA (55 - 62)
|
KVVRFDKL |
1 mg |
64412 |
| OVA (323 - 339)
|
ISQAVHAAHAEINEAGR |
1 mg
5 mg |
27024
27025 |
| OVA (323 - 339), amide
|
ISQAVHAAHAEINEAGR - NH2 |
1 mg
5 mg |
62571-1
62571-5 |
| OVA (327 - 333)
|
VHAAHAE |
1 mg |
62577 |
| β - catenin peptide, (βCATp)
|
RTYTYEKL |
1 mg |
61659 |
| Vesicular Stomatitis
Virus Nucleoprotein (52 - 59), VSV - 8 |
RGYVYQGL |
1 mg |
60785 |
| HSV - gB2 (498 – 505) |
SSIEFARL |
1 mg |
61708 |
Related
Products
Full listing of
Immunology related GO™ Peptides
Anti-CD antibodies
References:
- Heemel, M
& H. Ploegh Annu. Rev. Biochem. 64, 463 (1995).
- Beninga, J. et al. J.
Biol. Chem. 273, 18734 (1998).
- Hin,
S. et al. J. Biol. Chem. 276, 48790 (2001).
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