OVA (SIINFEKL) Peptides & Variants are GO™


Proteolytic processing of proteins in the cytoplasm generates peptide epitopes that are generally 8-10 amino acids in length. The binding of these peptides to the surface major histocompatibility complex (MHC) class I molecules and subsequent presentation to T-cells elicits an immune response.1 A model antigen extensively studied is Ovalbumin (OVA). OVA is processed to the presenting octapeptide (257-264), SIINFEKL, through proteasomal and non-proteasomal activities.2 As with peptides naturally presented by H-2Kb, SIINFEKL has on its 5th position an amino acid with an aromatic side chain (Phe) and on the 8th position, an aliphatic side chain (Leu).3 Variants of this peptide consisting of substituting different amino acids at strategic positions have yielded valuable information on the interaction of this peptide and the MHC complex.3

The use of AnaSpec’s SIINFEKL has been reported in peer-reviewed journals since 1997. We are pleased that researchers have trusted us to provide this important peptide. We are also pleased to announce the recent release of variants of this peptide.

Product

Sequence Size

Catalog #

OVA (257 - 264)

SIINFEKL

1 mg

5 mg

60193-1

60193-5

OVA (257 - 264), amide

SIINFEKL - NH2

1 mg

5 mg

62572-1

62572-5

OVA (257 - 264), scrambled

FILKSINE

1 mg

64413

OVA (257 - 264) Variant E1

Pyr - IINFEKL

1 mg

60793

OVA – E1 Peptide, (E257) Variant

EIINFEKL

1 mg

62194

OVA - A2 Peptide, OVA (257 - 264) Variant NEW

SAINFEKL

1 mg

64383

OVA - G4 Peptide, OVA (257 - 264) Variant NEW

SIIGFEKL

1 mg

64384

OVA - K4 Peptide, OVA (257 - 264) Variant NEW

SIIKFEKL

1 mg

64401

OVA - Q4 Peptide, OVA (257 - 264) Variant NEW

SIIQFEKL

1 mg

64402

OVA - R4 Peptide, OVA (257 - 264) Variant NEW

SIIRFEKL

1 mg

64382

OVA - T4 Peptide, OVA (257 - 264) Variant NEW

SIITFEKL

1 mg

64403

OVA - Q4H7 Peptide, OVA (257 - 264) Variant NEW

SIIQFEHL

1 mg

64405

V-OVA Peptide, OVA (257 - 264) Variant NEW

RGYNYEKL

1 mg

64406

Leu - OVA (257 - 264),

LSIINFEKL

1 mg

64407

Lys - OVA (257 - 264),

KSIINFEKL

1 mg

64408

Tyr - OVA (257 - 264),

YSIINFEKL

1 mg

64409

Met - OVA (257 - 264), MSL8

MSIINFEKL

1 mg

5 mg

62573-1

62573-5

N6-OVA, OVA (251 - 264)

GLEQLESIINFEKL

1 mg

64410

N9-OVA, OVA (248 - 264)

EVSGLEQLESIINFEKL

1 mg

64411


Related OVA Peptides

Product

Sequence

Size

Catalog #

OVA - BIP Hybrid Peptide

SIINFEKLGSGHWDFAWPW

1 mg

5 mg

60194-1

60194-5

OVA (55 - 62)

KVVRFDKL

1 mg

64412

OVA (323 - 339)

ISQAVHAAHAEINEAGR

1 mg

5 mg

27024

27025

OVA (323 - 339), amide

ISQAVHAAHAEINEAGR - NH2

1 mg

5 mg

62571-1

62571-5

OVA (327 - 333)

VHAAHAE

1 mg

62577

β - catenin peptide, (βCATp)

RTYTYEKL

1 mg

61659

Vesicular Stomatitis Virus Nucleoprotein (52 - 59), VSV - 8

RGYVYQGL

1 mg

60785

HSV - gB2 (498 – 505)

SSIEFARL

1 mg

61708

Related Products

Full listing of Immunology related GO™ Peptides

Anti-CD antibodies

References:

  1. Heemel, M & H. Ploegh Annu. Rev. Biochem. 64, 463 (1995).
  2. Beninga, J. et al. J. Biol. Chem. 273, 18734 (1998).
  3. Hin, S. et al. J. Biol. Chem. 276, 48790 (2001).