Chromatin exist either as the transcriptionally
active euchromatin or as the transcriptionally repressed heterchromatin state.1
Post-translational modifications of histone
“tails” (amino termini) have been implicated in the conversion between the two
states. 1-2
Covalent modifications, such as acetylation,
methylation and phosphorylation affect chromatin structure and exquisitely regulate
gene expression.3-6 Histone hyperacetylation is correlated with increased
transcription, whereas hypoacetylation correlates with transcriptional repression.5
In Histone H3, preferential methylation sites have been shown to be Lys-4, Lys-9,
Lys-27 and Lys-36, with methylation generally
leading to transcriptional suppression.3,7 Phosphorylation at Ser10
(pSer10) is implicated in both transcription and cell division.8
AnaSpec, the world’s largest provider of on-demand GO™ peptides
is pleased to announce the rapid expansion of our histone H3 peptide selection.
These new Histone H3 GO™ Peptides include sequences that are acetylated,
mono-, di- or tri-methylated, phosphorylated and biotinylated.
| Product |
Size |
Catalog
# |
| [Lys(Me1)4] - Histone H3 (1
- 10), H3K4(Me1) NEW
ART - K(Me1) - QTARKS |
1 mg |
64369-1 |
| [Lys(Me2)4] - Histone H3 (1
- 10), H3K4(Me2) NEW
ART - K(Me2) - QTARKS |
1 mg |
64370-1 |
| [Lys(Me3)4] - Histone H3 (1
- 10), H3K4(Me3) NEW
ART - K(Me3) - QTARKS |
1 mg |
64371-1 |
| Product |
Size |
Catalog
# |
| [Lys(Ac)14] - Histone H3 (1 -
19), H3K14(Ac)
ARTKQTARKSTGG - K(Ac) - APRKQ |
1 mg |
63682 |
| Histone H3 (1 - 20), N - Terminal
ARTKQTARKSTGGKAPRKQL |
1 mg |
62753 |
| [Lys(Ac)9] - Histone H3 (1 - 20),
H3K9(Ac)
ARTKQTAR - K(Ac) - STGGKAPRKQL |
1 mg |
63680 |
| Histone H3 (1 - 21), FAM labeled NEW
ARTKQTARKSTGGKAPRKQLAGG - K(FAM) - NH2 |
1 mg |
63824 |
| Histone H3 (1 - 21), N - Terminal
ARTKQTARKSTGGKAPRKQLA |
1 mg |
61701 |
| Histone H3 (1 - 21) - Cys NEW
ARTKQTARKSTGGKAPRKQLAC |
1 mg |
63789 |
| [Lys(Me2)4] - Histone
H3 (1 - 21), H3K4(Me2)
ART - K(Me2) - QTARKSTGGKAPRKQLA |
1 mg |
63677 |
| Histone H3 (1 - 21), K4 di - methylated, H3K4(Me2),
FAM labeled NEW
ART - K(Me2) - QTARKSTGGKAPRKQLAGG - K(FAM) -
NH2 |
1 mg |
63825 |
| [Lys(Ac)9] - Histone
H3 (1 - 21), H3K9(Ac)
ARTKQTAR - K(Ac) -STGGKAPRKQLA |
1 mg |
64191 |
| [Lys(Me3)9] - Histone
H3 (1 - 24), H3K9(Me3)
ARTKQTAR - K(Me3) - STGGKAPRKQLATKA |
0.5 mg |
63679 |
| Histone H3 (1 - 25), amide
ARTKQTARKSTGGKAPRKQLATKAA - NH2 |
1 mg |
61703 |
| [Lys(Me3)9] - Histone H3 (3
- 17), H3K9(Me3) NEW
TKQTAR - K(Me3) - STGGKAPR |
1 mg |
64374-1 |
| [Lys(Ac)14] - Histone H3 (9 -
19), H3K14(Ac)
KSTGG - K(Ac) - APRKQ |
1 mg |
63681 |
| Product |
Size |
Catalog
# |
| [Lys(Me1)9] - Histone H3 (3
- 17), H3K9(Me1) NEW
TKQTAR - K(Me1) - STGGKAPR |
1 mg |
64372-1 |
| [Lys(Me2)9] - Histone H3 (3
- 17), H3K9(Me2) NEW
TKQTAR - K(Me2) - STGGKAPR |
1 mg |
64373-1 |
| [Lys(Me3)9] - Histone H3 (3
- 17), H3K9(Me3) NEW
TKQTAR - K(Me3) - STGGKAPR |
1 mg |
64374-1 |
| Product |
Size |
Catalog
# |
| Histone H3 (23 - 34) NEW
KAARKSAPATGG |
1 mg |
64375-1 |
| [Lys(Me1)27] - Histone H3 (23
- 34), H3K27(Me1) NEW
KAAR - K(Me1) - SAPATGG |
1 mg |
64376-1 |
| [Lys(Me2)27] - Histone H3 (23
- 34), H3K27(Me2) NEW
KAAR - K(Me2) - SAPATGG |
1 mg |
64377-1 |
| [Lys(Me3)27] - Histone H3 (23
- 34), H3K27(Me3) NEW
KAAR - K(Me3) - SAPATGG |
1 mg |
64378-1 |
| Product |
Size |
Catalog
# |
| [Lys(Me1)36] - Histone H3 (31
- 41), H3K36(Me1) NEW
STGGV - K(Me1) - KPHRY |
1 mg |
64379-1 |
| [Lys(Me2)36] - Histone H3 (31
- 41), H3K36(Me2) NEW
STGGV - K(Me2) - KPHRY |
1 mg |
64380-1 |
| [Lys(Me3)36] - Histone H3 (31
- 41), H3K36(Me3) NEW
STGGV - K(Me3) - KPHRY |
1 mg |
64381-1 |
| Product |
Size |
Catalog
# |
| Histone H3 (1 - 21), biotin-labeled
ARTKQTARKSTGGKAPRKQLA - GGK(Biotin) - NH2 |
1 mg |
61702 |
| [Lys(Me1)4] - Histone H3 (1
- 21) - GGK(Biotin), H3K4(Me1), biotin - labeled NEW
ART - K(Me1) - QTARKSTGGKAPRKQLA - GGK(Biotin) |
0.25 mg
1 mg |
64355-025
64355-1 |
| [Lys(Me2)4] - Histone H3 (1
- 21) - GGK(Biotin), H3K4(Me2), biotin - labeled NEW
ART - K(Me2) - QTARKSTGGKAPRKQLA - GGK(Biotin) |
0.25 mg
1 mg |
64356-025
64356-1 |
| [Lys(Me3)4] - Histone H3 (1
- 21) - GGK(Biotin), H3K4(Me3), biotin - labeled NEW
ART - K(Me3) - QTARKSTGGKAPRKQLA - GGK(Biotin) |
0.25 mg
1 mg |
64357-025
64357-1 |
| Product |
Size |
Catalog
# |
| [Lys(Me1)9] - Histone H3 (1
- 21) - GGK(Biotin), H3K9(Me1), biotin - labeled NEW
ARTKQTAR - K(Me1) - STGGKAPRKQLA - GGK(Biotin) |
0.25 mg
1 mg |
64358-025
64358-1 |
| [Lys(Me2)9] - Histone H3 (1
- 21) - GGK(Biotin), H3K9(Me2), biotin - labeled NEW
ARTKQTAR - K(Me2) - STGGKAPRKQLA - GGK(Biotin) |
0.25 mg
1 mg |
64359-025
64359-1 |
| [Lys(Me3)9] - Histone H3 (1
- 21) - GGK(Biotin), H3K9(Me3), biotin - labeled NEW
ARTKQTAR - K(Me3) - STGGKAPRKQLA - GGK(Biotin) |
0.25 mg
1 mg |
64360-025
64360-1 |
| [Lys(Me2)9] - Histone H3 (1 - 21) - K(Biotin), H3K9(Me2),
biotin labeled NEW
ARTKQTAR - K(Me2) - STGGKAPRKQLA - K(Biotin) |
1 mg |
63678 |
| Product |
Size |
Catalog
# |
| Histone H3 (21 - 44) - GK(Biotin), H3K27, biotin – labeled NEW
ATKAARKSAPATGGVKKPHRYRPG-GK(Biotin) |
0.25 mg
1 mg |
64440-025
64440-1 |
| [Lys(Me1)27] - Histone H3 (21
- 44) - GK(Biotin), H3K27(Me1), biotin - labeled NEW
ATKAAR - K(Me1) - SAPATGGVKKPHRYRPG - GK(Biotin) |
0.25 mg
1 mg |
64365-025
64365-1 |
| [Lys(Me2)27] - Histone H3 (21
- 44) - GK(Biotin), H3K27(Me2), biotin - labeled NEW
ATKAAR - K(Me2) - SAPATGGVKKPHRYRPG - GK(Biotin) |
0.25 mg
1 mg |
64366-025
64366-1 |
| [Lys(Me3)27] - Histone H3 (21
- 44) - GK(Biotin), H3K27(Me3), biotin - labeled NEW
ATKAAR - K(Me3) - SAPATGGVKKPHRYRPG - GK(Biotin) |
0.25 mg
1 mg |
64367-025
64367-1 |
| Product |
Size |
Catalog
# |
| Histone H3 (21 - 44) - GK(Biotin), H3K27, biotin – labeled NEW
ATKAARKSAPATGGVKKPHRYRPG-GK(Biotin) |
0.25 mg
1 mg |
64440-025
64440-1 |
| [Lys(Me1)36] - Histone H3 (21
- 44) - GK(Biotin), H3K36(Me1), biotin - labeled NEW
ATKAARKSAPATGGV - K(Me1) - KPHRYRPG - GK(Biotin) |
0.25 mg
1 mg |
64368-025
64368-1 |
| [Lys(Me2)36] - Histone H3 (21
- 44) - GK(Biotin), H3K36(Me2), biotin - labeled NEW
ATKAARKSAPATGGV - K(Me2) - KPHRYRPG - GK(Biotin) | 0.25 mg
1 mg |
64442-025
64442-1 |
| [Lys(Me3)36] - Histone H3 (21
- 44) - GK(Biotin), H3K36(Me3), biotin - labeled NEW
ATKAARKSAPATGGV - K(Me3) - KPHRYRPG - GK(Biotin) |
0.25 mg
1 mg |
64441-025
64441-1 |
|
| Product |
Size |
Catalog
# |
| [Lys(Ac)9] - Histone H3 (1 - 21) - GGK(Biotin),
H3K9(Ac), biotin - labeled NEW
ARTKQTAR - K(Ac) - STGGKAPRKQLA - GGK(Biotin) |
0.25 mg
1 mg |
64361-025
64361-1 |
| [Lys(Ac)9] - Histone H3 (1 - 21) - NH2,
H3K9(Ac), biotin - labeled, amide NEW
ARTKQTAR - K(Ac) - STGGKAPRKQLA - GGK(Biotin) - NH2 |
1 mg |
64190 |
| [Lys(Ac)14] - Histone H3 (1 - 21) - GGK(Biotin),
H3K14(Ac), biotin - labeled NEW
ARTKQTARKSTGG - K(Ac) - APRKQLA - GGK(Biotin) |
0.25 mg
1 mg |
64362-025
64362-1 |
| [Lys(Ac)9/14] - Histone H3 (1 - 21) -
GGK(Biotin), H3K9/14(Ac), biotin - labeled NEW
ARTKQTAR - K(Ac) - STGG - K(Ac) - APRKQLA - GGK(Biotin) |
0.25 mg
1 mg |
64363-025
64363-1 |
| [pSer10), Lys(Ac)14] - Histone H3 (1 -
21) - GGK(Biotin), biotin - labeled NEW
ARTKQTARK - pS - TGG - K(Ac) - APRKQLAGGK(Biotin) |
0.25 mg
1 mg |
64364-025
64364-1 |
Related Products
Histone H1 Peptides
Histone H2A Peptides
Histone H4 Peptides
Histone Related Substrates
AnaSpec is the sole provider of the industry’s
long wavelength HDAC assay kit, the SensoLyte 520 HDAC
Activity Assay Kit. We also provide unusual amino acid building blocks such
as Lys(Ac),
Lys(Me1-3), Arg(Me2)
, pSer
and pThr
for histone peptide synthesis.
References:
1. Grunstein,
M. et al. J. Cell Sci. Suppl. 19, 29 (1995).
2. Strahl,
BR and CD Allis, Nature 403, 41 (2000).
3. Strahl,
BD. et al. Proc. Natl. Acad. Sci. 96, 14967 (1999).
4. Jenuwein,
T. and CD. Allis Science 293, 1074 (2001).
5. Sterner,
DE. et al. Microbiol. Mol. Biol. Rev. 64, 435 (2000).
6. Lachner,
M. et al. J. Cell Sci. 116, 2117 (2003).
7. Nishioka,
K. et al. Genes & Dev. 16, 479 (2002).
8. Prigent,
C. and S. Dimitrov, J. Cell Sci. 116, 3677 (2003).
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