The RGD (Arg-Gly-Asp) tripeptide motif can be found in extracellular matrix (ECM) proteins such as fibronectin, fibrinogen, prothrombin, tenascin, thrombospondin, vitronectin, von Willebrand factor, Adenovirus penton base protein, bone sialoprotein, collagen, decorsin, disintegrins.^1-2 The exposed RGD motif constitutes a major recognition site for integrin binding.³ Integrin, a transmembrane heterodimeric protein, is an adhesion protein consisting of an alpha and a beta subunit. Interaction of integrin with ECM proteins modulates vital bidirectional signals during morphogenesis, tissue remodeling and repair.^4-5 A well-studied interaction between integrin and ECM protein is that of αvβ₃ integrin with Fibronectin (FN), a major ECM protein (Figure 1). This interaction modulates processes such as cell migration, adhesion and angiogenesis ^5-6 FN contains FNIII repeats, with pockets of RGD. Synthetic cyclic RGD peptides have been found to be selective and potent αvβ₃ integrin antagonist resulting in inhibition of angiogenesis.⁶

As part of our GO™ Peptide offering, AnaSpec is pleased to offer a select group of cyclic and non-cyclic RGD peptides.

Figure 1. Schematic diagram of fibronectin bound to integrin at the cell surface (Theoretical and Computational Biophysics Group, NIH Resource for Macromolecular Modeling and Bioinfomatics, Univ of Illinois at Urbana-Champaign. Retrieved Jan. 12, 2010, from http://www.ks.uiuc.edu/Research/fibronectin/).

Product	Size	Catalog #
Cyclo (-RGDyK) Cyclo(-RGDyK)	1 mg 5 mg	61183-1 61183-5
Cyclo [-RGDyK(HiLyte Fluor™ 750)] Cyclo[-RGDy-K(Hilyte Fluor™ 750)]	0.1 mg 1 mg	62333-01 62333-1
Cyclo (-RGDfC), avb3 Integrin Binding Cyclic RGD Peptide Cyclo(-RGDfC)	1 mg	63785-1
Cyclo (-RGDfK) Cyclo(-RGDfK)	1 mg	61111
Cyclo [-RGDfK(Ac-SCH2CO)] Cyclo[-RGDfK(Ac-SCH2CO)]	1 mg 5 mg	61184-1 61184-5
Cyclo (-RADfE), RGD negative control Cyclo(-RADfE-)	1 mg	62352
Cyclo (-RADfK), RGD negative control Cyclo(-RADfK-)	1 mg	62351
Cyclo( -RaDYK), RGD negative control Cyclo( - RaDYK)	1 mg	64458
RGDS RGDS	5 mg	64457
RGES, Control for RGD Peptides RGES	1 mg	62527
GRGDS, LC-biotin labeled Biotin-LC-GRGDS	1 mg	62347
Integrin Binding Peptide Ac-GCGYGRGDSPG-NH2	1 mg	62349
GGGGRGDS GGGGRGDS	1 mg	62350
GRGDK, FAM-labeled GRGDK(5-FAM)	1 mg	62525
GRGDS GRGDS	5 mg	61107
GRGDS, amide GRGDS-NH2	5 mg	61108
Integrin-Binding Site, GRGDNP GRGDNP	1 mg	62049
GRGDSP GRGDSP	1 mg 5 mg	22945 22946
Cyclo (-GRGDSP) cyclo(-GRGDSP)	1 mg 5 mg	61110 61110-5
Prototype of RGD-containing peptide, FITC-labeled FITC-LC-GRGDSP	1 mg	60619
GRGDTP GRGDTP	1 mg 5 mg	22947 22948
GRGDSPK GRGDSPK	1 mg	61109
Cyclo-[GRGESP] Cyclo-[GRGESP]	1 mg	64447
GRADSPK GRADSPK	1 mg	60688
RGD-4C ACDCRGDCFCG (Disulfide bridge: 2-10 and 4-8)	1 mg 5 mg	29897 29898
RGD-targeted Proapoptotic Peptide ACDCRGDCFC-GG-klaklakklaklak-NH2 (S-S bo nded C1-C4 & C2-C3)	1 mg	62207
TP508, Thrombin-derived Peptide AGYKPDEGKRGDACEGDSGGPFV	1 mg	62338
YRGDS Fibronectin Fragment YRGDS	1 mg	62654
RGYSLG Peptide RGYSLG	1 mg	64138
Fibrinogen Binding Inhibitor Peptide HHLGGAKQAGDV	1 mg	60700

Click on the link below for a poster on:

In vivo Imaging Using Tissue Specific Near Infrared Fluorescent Peptide Conjugate, c[RGDyK(HiLyte Fluor™ 750)]

References:

1. Brooks, PC. Eur. J. Cancer 32a: 2423 (1996).
2. Plow, EF. et al. J. Biol. Chem. 275, 21785 (2000).
3. Ruoslahti, E. Ann. Rev. Cell Dev. Bio. 12, 697 (1996).
4. Humphries, MJ. Biochem. Soc. Trans. 28, 311 (2000).
5. Xiong, J-P. et al. Science 296, 5565 (2002).
6. Elceiri, BP. and DA. Cheresh, J. Clin. Invest. 103, 1227 (1999).