RGD Peptides are GO™


The RGD (Arg-Gly-Asp) tripeptide motif can be found in extracellular matrix (ECM) proteins such as fibronectin, fibrinogen, prothrombin, tenascin, thrombospondin, vitronectin, von Willebrand factor, Adenovirus penton base protein, bone sialoprotein, collagen, decorsin, disintegrins.1-2 The exposed RGD motif constitutes a major recognition site for integrin binding.3 Integrin, a transmembrane heterodimeric protein, is an adhesion protein consisting of an alpha and a beta subunit. Interaction of integrin with ECM proteins modulates vital bidirectional signals during morphogenesis, tissue remodeling and repair.4-5 A well-studied interaction between integrin and ECM protein is that of αvβ3 integrin with Fibronectin (FN), a major ECM protein (Figure 1). This interaction modulates processes such as cell migration, adhesion and angiogenesis 5-6 FN contains FNIII repeats, with pockets of RGD. Synthetic cyclic RGD peptides have been found to be selective and potent αvβ3 integrin antagonist resulting in inhibition of angiogenesis.6

As part of our GO™ Peptide offering, AnaSpec is pleased to offer a select group of cyclic and non-cyclic RGD peptides.

Figure 1. Schematic diagram of fibronectin bound to integrin at the cell surface (Theoretical and Computational Biophysics Group, NIH Resource for Macromolecular Modeling and Bioinfomatics, Univ of Illinois at Urbana-Champaign. Retrieved Jan. 12, 2010, from http://www.ks.uiuc.edu/Research/fibronectin/).

Product

Size

Catalog #

Cyclo (-RGDyK)
Cyclo(-RGDyK)

1 mg

5 mg

61183-1

61183-5

Cyclo [-RGDyK(HiLyte™ Fluor 750)]
Cyclo[-RGDy-K(Hilyte™ Fluor 750)]

0.1 mg

1 mg

62333-01

62333-1

Cyclo (-RGDfC), avb3 Integrin Binding Cyclic RGD Peptide
Cyclo(-RGDfC)

1 mg

63785-1

Cyclo (-RGDfK)
Cyclo(-RGDfK)

1 mg

61111

Cyclo [-RGDfK(Ac-SCH2CO)]
Cyclo[-RGDfK(Ac-SCH2CO)]

1 mg

5 mg

61184-1

61184-5

Cyclo (-RADfE), RGD negative control
Cyclo(-RADfE-)

1 mg

62352

Cyclo (-RADfK), RGD negative control
Cyclo(-RADfK-)

1 mg

62351

Cyclo( -RaDYK), RGD negative control
Cyclo( - RaDYK)

1 mg

64458

RGDS
RGDS

5 mg

64457

RGES, Control for RGD Peptides
RGES

1 mg

62527

GRGDS, LC-biotin labeled
Biotin-LC-GRGDS

1 mg

62347

Integrin Binding Peptide
Ac-GCGYGRGDSPG-NH2

1 mg

62349

GGGGRGDS
GGGGRGDS

1 mg

62350

GRGDK, FAM-labeled
GRGDK(5-FAM)

1 mg

62525

GRGDS
GRGDS

5 mg

61107

GRGDS, amide
GRGDS-NH2

5 mg

61108

Integrin-Binding Site, GRGDNP
GRGDNP

1 mg

62049

GRGDSP
GRGDSP

1 mg

5 mg

22945

22946

Cyclo (-GRGDSP)
cyclo(-GRGDSP)

1 mg

5 mg

61110

61110-5

Prototype of RGD-containing peptide, FITC-labeled
FITC-LC-GRGDSP

1 mg

60619

GRGDTP
GRGDTP

1 mg

5 mg

22947

22948

GRGDSPK
GRGDSPK

1 mg

61109

Cyclo-[GRGESP]
Cyclo-[GRGESP]

1 mg

64447

GRADSPK
GRADSPK

1 mg

60688

RGD-4C
ACDCRGDCFCG (Disulfide bridge: 2-10 and 4-8)

1 mg

5 mg

29897

29898

RGD-targeted Proapoptotic Peptide
ACDCRGDCFC-GG-klaklakklaklak-NH2 (S-S bo
nded C1-C4 & C2-C3)

1 mg

62207

TP508, Thrombin-derived Peptide
AGYKPDEGKRGDACEGDSGGPFV

1 mg

62338

YRGDS Fibronectin Fragment
YRGDS

1 mg

62654

RGYSLG Peptide
RGYSLG

1 mg

64138

Fibrinogen Binding Inhibitor Peptide
HHLGGAKQAGDV

1 mg

60700

Click on the link below for a poster on:

In vivo Imaging Using Tissue Specific Near Infrared Fluorescent Peptide Conjugate, c[RGDyK(HiLyte™ Fluor 750)]

References:

1. Brooks, PC. Eur. J. Cancer 32a: 2423 (1996).
2. Plow, EF. et al. J. Biol. Chem. 275, 21785 (2000).
3. Ruoslahti, E. Ann. Rev. Cell Dev. Bio. 12, 697 (1996).
4. Humphries, MJ. Biochem. Soc. Trans. 28, 311 (2000).
5. Xiong, J-P. et al. Science 296, 5565 (2002).
6. Elceiri, BP. and DA. Cheresh, J. Clin. Invest. 103, 1227 (1999).