PEGylation has become a well-accepted method for the delivery of biopharmaceuticals-especially
peptide and protein drugs.1-4 Simple modification of a drug with
polyethylene glycol (PEG) not only is capable of improving the drug’s solubility,
diminishing the potential for aggregation, and minimizing interference for both
in vitro and in vivo applications, but is also able to protect
it from proteolytic digestion, increasing its half-life in biological applications
in the process.1-4
AnaSpec is pleased to highlight our wide collection of Fmoc- and Boc-protected
PEGylated amino acids for PEGylated peptides synthesis (Table 1). As well, custom
synthesis of PEGylated peptides is available through our Fremont, California
facilities. To obtain a price quotation, please click here or email service@anaspec.com.
Table 1. Boc- and Fmoc-protected PEGylated amino acids.
| Product |
Size |
Catalog # |
| Boc-NH-(PEG)3-CH2CH2COOH
Boc-9-Amino-4,7-Dioxanonanoic acid
 |
1 g
5 g |
65031-1
65031-5 |
| Boc-NH-(PEG)4-CH2CH2COOH
Boc-15-amino-4,7,10,13-tetraoxapentadecacanoic acid
 |
1 g
5 g |
65030-1
65030-5 |
| Boc-NH-(PEG)6-CH2CH2COOH
Boc-21-amino-4,7,10,13,16,19-hexaoxaheneicosanoic acid
 |
1 g
5 g |
65029-1
65029-5 |
| Boc-NH-(PEG)8-CH2CH2COOH
 |
1 g
5 g |
65028-1
65028-5 |
| Boc-NH-(PEG)10-CH2CH2COOH
 |
0.25 g
0.5 g
1 g
5 g |
65027-025
65027-05
65027-1
65027-5 |
| Boc-NH-(PEG)12-CH2CH2COOH
 |
0.25 g
0.5 g
1 g
5 g |
65026-025
65026-05
65026-1
65026-5 |
| Fmoc-AEEAc-OH
{2-[2-(Fmoc-amino)-ethoxy]-ethoxy}acetic acid; CAS# 166108-71-0
|
500 mg
1 g |
64241-500
64241-1000 |
| Fmoc-NH-(PEG)1-CH2CH2COOH
Fmoc-AEP; Fmoc-6-Amino-4-oxahexanoic acid; [3-(Fmoc-amino)ethoxy]propionic
acid
|
1 g
5 g |
65040-1
65040-5 |
| Fmoc-NH-(PEG)1-CH2COOH
Fmoc-AEA; Fmoc-5-Amino-3-Oxapentamoic Acid; CAS# 260367-12-2
 |
1 g
5 g |
65025-1
65025-5 |
| Fmoc-NH-(PEG)2-CH2CH2COOH
Fmoc-9-Amino-4,7-Dioxanonanoic acid; Fmoc-3-(2-(2-aminoethoxy)ethoxy)propanoic
acid; CAS# 872679-70-4
|
1 g
5 g |
65039-1
65039-5 |
| Fmoc-NH-(PEG)3-CH2CH2COO
Fmoc-12-amino-4,7,10-trioxadodecanoic acid; CAS# 867062-95-1
 |
1 g
5 g |
65038-1
65038-5 |
| Fmoc-NH-(PEG)4-CH2CH2COOH
Fmoc-15-amino-4,7,10,13-tetraoxapentadecacanoic acid; CAS# 557756-85-1
 |
1 g
5 g |
65037-1
65037-5 |
| Fmoc-NH-(PEG)5-CH2CH2COOH
Fmoc-18-amino-4,7,10,13,16-pentaoxaoctadecanoic acid; CAS# 882847-32-7
 |
1 g
5 g |
65036-1
65036-5 |
| Fmoc-NH-(PEG)6-CH2CH2COOH
Fmoc-21-amino-4,7,10,13,16,19-hexaoxaheneicosanoic acid; CAS# 882847-34-9
 |
1 g
5 g |
65035-1
65035-5 |
| Fmoc-NH-(PEG)8-CH2CH2COOH
1-(9H-fluoren-9-ylmethyl)ester; 5,8,11,14,17,20,23,26-Octaoxa-2-
azanonacosanedioic acid; CAS# 756526-02-0
 |
1 g
5 g |
65034-1
65034-5 |
| Fmoc-NH-(PEG)10-CH2CH2COOH
 |
1 g
5 g |
65033-1
65033-5 |
| Fmoc-NH-(PEG)12-CH2CH2COOH
CAS# 756526-01-9
 |
1 g
5 g |
65032-1
65032-5 |
| Fmoc-NH-dPEG3-COOH
Fmoc-AEEEA; Fmoc-11-amino-3,6,9-trioxaundecanoic acid; CAS# 139338-72-0
 |
1 g
5 g |
65043-1
65043-5 |
| Fmoc-NH-dPEG5-COOH
Fmoc-NH-5(ethylene glycol)-acetic acid; CAS# 635287-26-2
|
1 g
5 g |
65042-1
65042-5 |
| Fmoc-NH-dPEG8-COOH
Fmoc-NH-8(ethylene glycol)-acetic acid; CAS# 868594-52-9
 |
1 g
5 g |
65041-1
65041-5 |
References
1. Veronese, FM. Biomaterials 22, 405 (2001).
2. Roberts, MJ. et al. Adv Drug Delivery Rev 54,
459 (2002).
3. Chapman, AP. Adv Drug Delivery Rev 54, 531 (2002).
4. DeFrees, S. et al. Glycobio 16, 833 (2006).
|
