Dipeptide and tripeptide libraries can be systematically constructed
to contain almost all possible combinations of the 20 common amino acids.1
Peptide libraries can be used in the study of ligand-receptor interactions,
epitope mapping, vaccine development, and drug screening.2 Dipeptide
libraries, in particular, can be prepared at relatively low cost to span a broad
range of physicochemical properties, making them especially useful to pharmaceutical
companies as a potential source for novel drug structures.3 Another
advantage of dipeptide libraries is their simple structure, which eliminates
the need for deconvolution in identifying novel structures and allows the peptides
to be taken up by bacterial and eukaryotic cell membranes for direct interaction
with target proteins in vivo.3-6
AnaSpec, Eurogentec Group is pleased to release the following
dipeptides, the majority of which are >95% pure.
Table 1. A list of dipeptides. Yellow highlighted boxes denote
that the purity of peptides is less than 95%, grey boxes denote that the
peptides are not available.
1. Xiang, D. et al. Biochem 48,
2. Liu, R. et al. Exp Hematol 31,
3. Xie, J. et al. J Med Chem 52,
4. Boden, P. et al. J Med Chem 39,
5. Olson, E. et al. J Bacteriol
173, 234 (1991).
6. Saito, H. et al. Am J Physiol
265, 289 (1993).