Dipeptide and tripeptide libraries can be systematically constructed
to contain almost all possible combinations of the 20 common amino acids.1
Peptide libraries can be used in the study of ligand-receptor interactions,
epitope mapping, vaccine development, and drug screening.2 Dipeptide
libraries, in particular, have been prepared to study a broad
range of physicochemical properties, making them especially useful to pharmaceutical
companies as a potential source for novel drug structures.3 Another
advantage of dipeptide libraries is their simple structure, which eliminates
the need for deconvolution in identifying novel structures and allows the peptides
to be taken up by bacterial and eukaryotic cell membranes for direct interaction
with target proteins in vivo.3-6
AnaSpec, EGT Group is pleased to offer the following
Table 1. A list of dipeptides. Dipeptides containing N-terminal Glutamine or Glutamic acid are known to form pryoGlutamate (pGlu). The purity of the yellow highlighted peptides is expressed as a sum of both products (pGlu formation can vary from 20% to 50%), which is >95% pure by analytical HPLC. Once dissolved in solutions, these dipeptides should be utilized fairly quickly. Grey boxes denote that the
peptides are not available. Unless otherwise specified, all other peptides are >95%.
1. Xiang, D. et al. Biochem 48,
2. Liu, R. et al. Exp Hematol 31,
3. Xie, J. et al. J Med Chem 52,
4. Boden, P. et al. J Med Chem 39,
5. Olson, E. et al. J Bacteriol
173, 234 (1991).
6. Saito, H. et al. Am J Physiol
265, 289 (1993).