Anti-β-Amyloid (1-40) & (1-42) mAbs - NEW


AnaSpec, Eurogentec Group is pleased to announce the release of two new mouse monoclonal antibodies specific for β-Amyloid (1-40) & (1-42). These two antibodies are of the IgG1 subtype and do not cross-react with each other at concentrations up to 50 ng/ml when tested in sandwich ELISA. They also do not cross-react with β-amyloid (1-37) and β-amyloid (1-38). Species reactivity includes human, mouse and rat. The immunogen used in raising anti-β-amyloid (1-40) corresponds to amino acid 35-40 (MVGGVV), and for anti-β-amyloid (1-42), aa 35-42 (MVGGVVIA).

Product

Size

Catalog #

Anti-β-Amyloid (1 - 40), mouse monoclonal NEW

50 µg

55921

Anti-β-Amyloid (1 - 42), mouse monoclonal NEW

50 µg

55922



Figure 1. IHC of brain tissue from APP Tg2576 transgenic mouse probed with mouse anti-β-amyloid (1-40) antibody (Cat. #55921). Paraformaldehyde fixed sections were pretreated with 70% formic acid for 5 minutes followed by steaming for 30 minutes and blocked with normal goat serum (no need for antigen retrieval if fresh or frozen sections are used). Sections were incubated with anti-β-amyloid (1-40) antibody at 0.5
mg/ml overnight. Immunoreactivity was visualized using DAKO Envision HRP System (1:10,000 dilution). This antibody stains cored plaques only. Image courtesy of Mayo Clinic Florida.



Figure 2. IHC of brain tissue fromAPP Tg2576 transgenic mouse probed with mouse anti-β-amyloid (1-42) antibody (Cat. #55922). Paraformaldehyde fixed sections were pretreated with 70% formic acid for 5 minutes followed by steaming for 30 minutes and blocked with normal goat serum (no need for antigen retrieval if fresh or frozen sections are used). Sections were incubated with anti-β–amyloid (1-42) antibody at 0.05
mg/ml concentration overnight. Immunoreactivity was visualized using DAKO Envision HRP System (1:10,000 dilution). This antibody stains both cored and diffused plaques. Image courtesy of Mayo Clinic Florida.


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