MOG Proteins – Special Pricing Extended through April 30, 2012


AnaSpec, EGT the first provider of commercial MOG recombinant proteins is pleased to offer a 50% discount off our regular prices on all MOG (1-125) recombinant proteins through the month of February, 2012 to our US and Canadian customers. Please mention code “rMOG50%” when ordering to get the discount.
Breaking News: 50% discount offer has been extended through to the end of April, 2012. Please use the same code.

Customers’ Feedback on AnaSpec’s MOG proteins:

Feedback #1: Your Recombinant Human MOG (1-125), Cat# 55158 is excellent in quality; technical support is also excellent. The datasheet is very well-written and delivery was excellent.

Feedback #2: Your Recombinant Rat MOG (1-125), Cat# 55152 is excellent in quality.

Our MOG proteins, with sequences corresponding to human, mouse and rat extracellular domain, together with a 6x His tag were expressed in E. coli and purified from urea denatured bacterial lysate. The molecular weight found in all 3 recombinant proteins was 14.23 kDa. All of these proteins have been shown to induce EAE.

Myelin Oligodendrocyte Glycoprotein (MOG), a 26- to 28-kDa protein, is a member of the immunoglobulin superfamily. It is expressed exclusively in the central nervous system (CNS), specifically on the surface of myelinating oligodendrocytes and external lamellae of myelin sheath. Although MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins, it was demonstrated that MOG protein is a crucial autoantigen for multiple sclerosis in humans and experimental autoimmune encephalomyelitis (EAE) in rodents and monkeys (1-6).

Recombinant MOG Protein

Size

Catalog #

Recombinant human MOG

100 µg

500 µg

1000 µg

55158-100

55158-500

55158-1000

Recombinant mouse MOG

100 µg

500 µg

1000 µg

55150-100

55150-500

55150-1000

Recombinant rat MOG

100 µg

500 µg

1000 µg

55152-100

55152-500

55152-1000



Figure 1. Purified recombinant MOGs (rMOG) was loaded onto 10-20% Tris-HCl SDS-PAGE (10 μg/well) and resolved at 200V for 60 minutes. Protein markers and the purified rMOG (14.2 kDa) are indicated. CL= Crude Cell Lysate, FT= Flow Through, and P = Purified rMOG.


Figure 2. Average EAE score of five female Dark Agouti rats (8 weeks old) injected with human MOG (1-125)

Related Products:
MOG Peptides
Anti-MOG Antibodies
SensoLyte® Anti-MOG IgG ELISA Assay Kits
MBP Peptides
PLP Peptides
Anti-PLPs
Anti-MBPs

References:

1. Linares, D. et al. Protein Expression and Purif. 34, 249 (2004).
2. Bettadapura, J. et al. J. Neurochem. 70, 1593 (1998).
3. Oliver, AR. et al. J. Immunol. 171, 462 (2003).
4. Von Budingen, H-C. et al. J. Clin. Immunol. 21, 155 (2001).
5. Lyons, J-A. et al. Eur. J. Immunol. 29, 3432 (1999).
6. Von Budingen, H-C. et al. Eur. J. Immunol. 34, 2072 (2003).