PEGylated Amino Acids


PEGylation has become a well-accepted method for the delivery of biopharmaceuticals-especially peptide and protein drugs.1-4 Simple modification of a drug with polyethylene glycol (PEG) not only is capable of improving the drug’s solubility, diminishing the potential for aggregation, and minimizing interference for both in vitro and in vivo applications, but is also able to protect it from proteolytic digestion, increasing its half-life in biological applications in the process.1-4

AnaSpec, EGT Group is pleased to highlight our wide collection of Fmoc- and Boc-protected PEGylated amino acids for PEGylated peptides synthesis (Table 1). As well, custom synthesis of PEGylated peptides is available through our Fremont, California facilities. To obtain a price quotation, please click here or email service@anaspec.com.

Table 1. Boc- and Fmoc-protected PEGylated amino acids.

Product

Size

Catalog #

Boc-NH-(PEG)3-CH2CH2COOH
Boc-9-Amino-4,7-Dioxanonanoic acid

1 g

5 g

65031-1

65031-5

Boc-NH-(PEG)4-CH2CH2COOH
Boc-15-amino-4,7,10,13-tetraoxapentadecacanoic acid

1 g

5 g

65030-1

65030-5

Boc-NH-(PEG)6-CH2CH2COOH
Boc-21-amino-4,7,10,13,16,19-hexaoxaheneicosanoic acid

1 g

5 g

65029-1

65029-5

Boc-NH-(PEG)8-CH2CH2COOH

1 g

5 g

65028-1

65028-5

Boc-NH-(PEG)10-CH2CH2COOH

0.25 g

0.5 g

1 g

5 g

65027-025

65027-05

65027-1

65027-5

Boc-NH-(PEG)12-CH2CH2COOH

0.25 g

0.5 g

1 g

5 g

65026-025

65026-05

65026-1

65026-5

Fmoc-AEEAc-OH
{2-[2-(Fmoc-amino)-ethoxy]-ethoxy}acetic acid; CAS# 166108-71-0

500 mg

1 g

64241-500

64241-1000

Fmoc-NH-(PEG)1-CH2CH2COOH
Fmoc-AEP; Fmoc-6-Amino-4-oxahexanoic acid; [3-(Fmoc-amino)ethoxy]propionic acid

1 g

5 g

65040-1

65040-5

Fmoc-NH-(PEG)1-CH2COOH
Fmoc-AEA; Fmoc-5-Amino-3-Oxapentamoic Acid; CAS# 260367-12-2

1 g

5 g

65025-1

65025-5

Fmoc-NH-(PEG)2-CH2CH2COOH
Fmoc-9-Amino-4,7-Dioxanonanoic acid; Fmoc-3-(2-(2-aminoethoxy)ethoxy)propanoic acid; CAS# 872679-70-4

1 g

5 g

65039-1

65039-5

Fmoc-NH-(PEG)3-CH2CH2COO
Fmoc-12-amino-4,7,10-trioxadodecanoic acid; CAS# 867062-95-1

1 g

5 g

65038-1

65038-5

Fmoc-NH-(PEG)4-CH2CH2COOH
Fmoc-15-amino-4,7,10,13-tetraoxapentadecacanoic acid; CAS# 557756-85-1

1 g

5 g

65037-1

65037-5

Fmoc-NH-(PEG)5-CH2CH2COOH
Fmoc-18-amino-4,7,10,13,16-pentaoxaoctadecanoic acid; CAS# 882847-32-7

1 g

5 g

65036-1

65036-5

Fmoc-NH-(PEG)6-CH2CH2COOH
Fmoc-21-amino-4,7,10,13,16,19-hexaoxaheneicosanoic acid; CAS# 882847-34-9

1 g

5 g

65035-1

65035-5

Fmoc-NH-(PEG)8-CH2CH2COOH
1-(9H-fluoren-9-ylmethyl)ester; 5,8,11,14,17,20,23,26-Octaoxa-2- azanonacosanedioic acid; CAS# 756526-02-0

1 g

5 g

65034-1

65034-5

Fmoc-NH-(PEG)10-CH2CH2COOH

1 g

5 g

65033-1

65033-5

Fmoc-NH-(PEG)12-CH2CH2COOH

CAS# 756526-01-9

1 g

5 g

65032-1

65032-5

Fmoc-NH-dPEG3-COOH
Fmoc-AEEEA; Fmoc-11-amino-3,6,9-trioxaundecanoic acid; CAS# 139338-72-0

1 g

5 g

65043-1

65043-5

Fmoc-NH-dPEG5-COOH
Fmoc-NH-5(ethylene glycol)-acetic acid; CAS# 635287-26-2


1 g

5 g

65042-1

65042-5

Fmoc-NH-dPEG8-COOH
Fmoc-NH-8(ethylene glycol)-acetic acid; CAS# 868594-52-9

1 g

5 g

65041-1

65041-5

References

1. Veronese, FM. Biomaterials 22, 405 (2001).
2. Roberts, MJ. et al. Adv Drug Delivery Rev 54, 459 (2002).
3. Chapman, AP. Adv Drug Delivery Rev 54, 531 (2002).
4. DeFrees, S. et al. Glycobio 16, 833 (2006).