NY-ESO-1 (87-111) - 1 mg
- Cat.Number : AS-62655
- Manufacturer Ref. :
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This is amino acids 81 to 111 fragment of the NY-ESO-1. The NY-ESO-1 antigen is expressed by many tumors of different histological types (including breast, prostate, lung, and melanoma) and by male germline cells, but not by other normal tissues. NY-ESO-1 encodes MHC class I- and class II-restricted peptides expressed by a diverse range of cancers and recognized by T cells. This peptide is pan-MHC class II-restricted sequence that is capable of binding to multiple HLA-DR and HLA-DP4 molecules, including HLA-DRB1*0101, 0401, 0701, and 1101 and HLA-DPB1*0401 and 0402 molecules.
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Citations
Profound elevation of CD8+ T cells expressing the intraepithelial lymphocyte marker CD103 (αE/β7 Integrin) in high-grade serous ovarian cancer
Gynecol Oncol . 2010 Jun 11 ; 118(3) 228 | DOI : 10.1016/j.ygyno.2010.05.016
- J. Webb
References
One NY-ESO-1-Derived Epitope That Promiscuously Binds to Multiple HLA-DR and HLA-DP4 Molecules and Stimulates Autologous CD4+ T Cells from Patients with NY-ESO-1-Expressing Melanoma
J Immunol . 2005 Feb 01 ; 174(3) 1751 | DOI : https://doi.org/10.4049/jimmunol.174.3.1751
- M. Mandic
- et al