AnaSpec News

25 New Peptides - January 10, 2008

This week AnaSpec introduced twenty-five (25) new catalog peptides to its extensive catalog.

[Ala28]-beta-Amyloid (1-40) - Cat# 61968-05
This is amino acids 1 to 40 fragment of the beta-Amyloid peptide; modified with the Ala28; replacing Lys28 residue.
Sequence: DAEFRHDSGYEVHHQALVFFAEDVGSNAGAIIGLMVGGVV

Cys Containing b-Amyloid (1-40) Binding Peptide - Cat# 62428
This peptide containing flanking cysteines was shown to bind b-Amyloid.(1-40) polimer form; but not monomeric b-Amyloid (1-40). Such peptides are useful as carrier molecules to deliver therapeutic and diagnostic reagents to amyloid plaques.
Sequence: AECDWGKGGRWRLWPGASGKTEACGP

Melittin; honey bee - Cat# 62366
Melittin; a 26-residue bee venom peptide; is known to induce murine antibodies specific for its hydrophilic C-terminus of residues 20 to 26 and T cell responses specific for its hydrophobic mid-region of residue 11 to 19. This peptide is the anti-inflammatory agent; it inhibits the lyme disease spirochete.
Sequence: GIGAVLKVLTTGLPALISWIKRKRQQ

Mycobacterium Tuberculosis Protein Ag85A - Cat# 62425
This is a T-cell immunodominant CD8 peptide of the Ag85A Mycobacterium tuberculosis protein; MHC class I H-2Ld-restricted epitope. Because parenterally administered Mycobacterium bovis BCG vaccine confers only limited immune protection from pulmonary tuberculosis; intranasal administration of vector expressing AdAg85A represents an effective way to boost immune protection by parenteral BCG vaccination.
Sequence: LTSELPGWLQANRHVKPTGS

BAD BH3 (103-123) - Cat# 62489
This is amino acids 103 to 123 fragment of BAD BH3 protein. BH3 domain of BAD is necessary for its ability to bind Bcl-2 and Bcl-XL and induce apoptosis. Mutations in this domain of the protein inhibit binding of BAD to Bcl-2 and Bcl-XL resulting in the apoptosis arrest; and possible neoplasia.
Sequence: NLWAAQRYGRELRRMSDEFVD

BAD BH3 (146-159); Paired - Cat# 62483
This is amino acids 146 to 159 fragment of BAD BH3 protein. This peptide belongs to the pro-apoptotic members of the Bcl-2 family. This non-phosphorylated peptide may be used as a control for the BAD BH3 protein phosphorylated at Ser155 . Phosphorylation at Ser155 inhibits the death-promoting activity of BAD.
Sequence: RYGRELRRMSDEFE

Bax BH3 (58-71) - Cat# 62486
This is amino acids 58 to 71 fragment of Bax BH3 protein. Bax is a major proapoptotic member of the Bcl2 family which is required for apoptotic cell death.
Sequence: KLSECLKRIGDELD

Bcl-2 BH3 (85-105) - Cat# 62494
This is amino acids 85 to 105 fragment of Bcl-2 BH3 protein. Cleavage of Bcl-2 loop domain by caspase-3 releases BH3 domain; which is a death-promoting region common to all members of Bcl-2 family. Bcl-2 BH3 domain contains a core sequence LRQAGDFS where Leu1 and Asp6 are critical for the homerization.
Sequence: ALSPVPVVHLTLRQAGDFSRR

Bcl-XL BH3 (85-98) - Cat# 62481
This is amino acids 85 to 98 fragment of Bcl-XL BH3 protein. The Bcl-XL is anti-apoptotic protein.
Sequence: AVKQALREAGDEFE

Bid BH3 (85-98) - Cat# 62485
This is amino acids 85 to 98 fragment of Bid BH3 protein. The BH3 domain of Bid is believed to play an essential role in Bax activation
Sequence: NIARHLAQVGDSMD

Bik BH3 (56-69) - Cat# 62487
This is amino acids 56 to 69 fragment of Bcl-2-interacting killer (Bik) BH3 domain. Bik BH3 peptides bind to Bcl-XL and can restore Bax/Bid-induced permeabilization in the presence of Bcl-XL. The BH3 domain of Bid is believed to play an essential role in Bax activation
Sequence: ALALRLACIGDEMD

Ghrelin (1-18) - Cat# 62358
This peptide is amino acids 1 to 18 fragment of ghrelin. Ghrelin is a potent agonist at the human growth hormone secretagogue receptor 1a (hGHSR1a). The entire sequence of ghrelin is not necessary for its activity. The segment Gly-Ser-Ser(n-octanoyl)-Phe appears to constitute the 'active core' required for agonist potency at hGHSR1a; and the 18 amino acid peptide displays some functions of the full length ghrelin peptide.
Sequence: GS-S(n-octanoyl)-FLSPEHQRVQQRKES

VIR-165; Alpha1-Antitrypsin Modification (353-372) - Cat# 62434
VIR-165 is a modified form of virus inhibitory peptide (VIRIP); which corresponds to residues 353 to 372 of C-proximal region of human alpha1-antitrypsin; the most abundant circulating serine protease inhibitor. VIRIP inhibits a wide variety of human immunodeficiency virus type 1 (HIV-1) strains. This modification enhances the antitrypsin ability to inhibit HIV-1infection.
Sequence: LEAIPCSIPPCFAFNKPFVF

Adeno-Associated Virus Epitope 2 (AAV2) - Cat# 62522
This peptide is capsid derived immunodominant adeno-associated virus 2 (AAV2); CD8 T cell epitope. Liver toxicity observed in a clinical trial of AAV2 delivered systemically to patients with hemophilia was ascribed to killing of vector-transduced hepatocytes by capsid-specific T cells.
Sequence: VPQYGYLTL

Catestatin; Chromogranin A (352-372); human - Cat# 62433
Catestatin is amino acids 352 to 372 fragment of chromogranin A (parathyroid secretory protein 1); neuroendocrine secretory protein. Catestatin is an inhibitor of catecholamine release.
Sequence: SSMKLSFRARAYGFRGPGPQ

CKK-Insulin Receptor Substrate 1 (IRS-1) (979-989); mouse - Cat# 62544
This peptide is amino acids 979 to 989 fragment of the murine insulin receptor substrate 1 (IRS-1) modified with additional residues Cys76; Lys77; Lys78 at the N-terminus. It contains the phosphorylation site at Tyr983.
Sequence: CKKSRGDYMTMQIG

Glutamate Receptor Endocytosis Inhibitor; control peptide (GluR23A) - Cat# 62548
This control peptide is used as a mutant counterpart to glutamate receptor endocytosis inhibitor (GST–GluR23Y). It was employed to investigate the effect of postsynaptic application of GST–GluR23Y during whole-cell recordings of CA1 neurons in hippocampal slices. Unlike GST–GluR23Y; GST–GluR23A; is not a tyrosine phosphorylation substrate.
Sequence: AKEGANVAG

Myelin oligodendrocyte glycoprotein (MOG 8-21) - Cat# 62369
This peptide is amino acids 8 to 21 fragment of the myelin oligodendrocyte glycoprotein (MOG). It induces relapsing experimental autoimmune encephalomyelitis (EAE) in mice associated with broadening of the autoimmune repertoire. Subtle changes in MOG (8-21) dramatically influences disease susceptibility and T cell responses in vitro.
Sequence: PGYPIRALVGDEAE

Erythropoietin Receptor Peptide (EpoR); pTyr429; acetylated; amide - Cat# 62346
This is amino acids 423 to 438 fragment of the Erythropoietin Receptor Peptide (EpoR); phosphorylated at Tyr429. It binds to the N-SH2 domain that has a function in regulation of the PTPase domain and thereby signal transduction. It activates SHP-1 (previously called PTP1C; HCP; and SHPTP1); a protein-tyrosine phosphatase with two Src homology 2 (SH2) domains predominantly expressed in hematopoietic cells.
Sequence: Ac-DPPHLK-pY-LYLVVSDSK-NH2

Histone 4 (1-20); PRMT7 Substrate; M1 - Cat# 62498
This GRG containing peptide is amino acids 1 to 20 fragment of histone 4. It is a substrate for human protein-arginine methyltransferase 7 (PRMT7); a type II methyltransferase capable of producing symmetrical dimethyl arginine (sDMA) modifications in proteins.
Sequence: SGRGKGGKGLGKGGAKRHRK-NH2

Histone 4-12; p300/CBP Substrate - Cat# 62500
This 12 residues long fragment (amino acids 3 to14) of the histone 4; is also known as H4-12. Histone acetyltransferase (HAT) p300/CBP catalyzes the acetylation of this N-terminal tail of free histone H4 at Lys5; 8; 12. Lys8 is thought to be the preferred acetylation site in H4. Determinants of interaction of p300 with histone 4 appear to be fully present on H4-12; the N-terminal region of the protein. H4-12. is functionally equal to the longer H4-21 peptide; despite the loss of nine amino acids.
Sequence: RGKGGKGLGKGA

Histone 4-21; p300/CBP Substrate - Cat# 62499
This sequence is amino acids 1 to 21 fragment of the histone 4. Histone acetyltransferase (HAT) p300/CBP catalyses the acetylation of this N-terminal tail of free histone H4 at Lys5; 8; 12; 16. Lys8 is thought to be the preferred acetylation site in H4. Determinants of interaction of p300 with histone 4 appear to be fully present on H4-21; the N-terminal region of the protein.
Sequence: SGRGKGGKGLGKGGAKRHRKV

NR-Box 2 Peptide - Cat# 62534
This 13-amino-acid peptide belongs to the nuclear receptor (NR)-box 2 proteins. NRs represent a class of regulatory factors that bind to signals; response elements; protein cofactors; and regulate target gene transcription. This sequence includes the conserved LxxLL motif of NR-boxes.
Sequence: KHKILHRLLQDSS

Bombolitin I - Cat# 62506
Bombolitin I is a small amphiphilic peptide isolated from bumblebee venom. At least 5 bombolitins have been characterized. This peptide elicits histamine release from rat peritoneal mast cells.
Sequence: IKITTMLAKLGKVLAHV

Influenza Virus Hemagglutinin (326-340) - Cat# 62423
This peptide is amino acids 326 to 340 fragment of the influenza virus hemagglutinin (HA). This HA326 peptide elicits strong gamma interferon (IFN-?) production in the intracellular cytokine assays.
Sequence: KQNTLKLATGMRNVP

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